"1"^^ . . "Telomery, telomer\u00E1zov\u00FD komplex a kolorekt\u00E1ln\u00ED karcinom" . "8"^^ . "\u010Cesk\u00E1 a slovensk\u00E1 gastroenterologie a hepatologie" . "An increasing incidence of tumor disease, including GIT malignancies, are well documented not only in the Czech Republic, but also in other countries worldwide. A remarkable effort has been directed toward the development of novel diagnostic approaches leading to early detection of tumorigenesis and cancer formation. Since the discovery that telomerase is strongly expressed in the vast majority of malignancies and contributes to genome instability in the cells, this enzymatic complex emerged as a promising target for early diagnostic and therapeutic purposes. According to many authors cancer treatment based on telomerase inhibition could be relatively specific, effective and safer. In this review I summarize the current knowledge concerning the telomerase complex and colon cancer, focusing on the role of telomerase in early diagnosis and prognosis of this malignant disease."@en . "60" . . "[3A3112EF5DD4]" . . . "colorectal cancer; telomeres; telomerase"@en . . "Telomery, telomer\u00E1zov\u00FD komplex a kolorekt\u00E1ln\u00ED karcinom"@cs . "11120" . . "Telomery, telomer\u00E1zov\u00FD komplex a kolorekt\u00E1ln\u00ED karcinom" . . . "6" . "\u0160vec, Ji\u0159\u00ED" . "RIV/00216208:11120/06:00002191" . "Zvy\u0161uj\u00EDc\u00ED se incidence n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED, zejm\u00E9na malignit gastrointestin\u00E1ln\u00EDho traktu je zaznamen\u00E1na nejen v \u010Cesk\u00E9 republice, ale i celosv\u011Btov\u011B. Jsou st\u00E1le hled\u00E1ny spolehliv\u00E9 diagnostick\u00E9 postupy umo\u017E\u0148uj\u00EDc\u00ED \u010Dasnou detekci n\u00E1dorov\u00E9ho procesu. Jedn\u00EDm z nich je telomer\u00E1zov\u00FD enzymatick\u00FD komplex, kter\u00FD se uplat\u0148uje v n\u00E1dorov\u00E9 transformaci a v rozvoji kancerogeneze. Zv\u00FD\u0161en\u00E1 exprese telomer\u00E1zy je prokazateln\u00E1 a\u017E u 90% malign\u00EDch n\u00E1dor\u016F. Uv\u00E1d\u00EDme proto mo\u017Enosti pr\u016Fkazu komponent telomer\u00E1zov\u00E9ho komplexu jako u\u017Eite\u010Dn\u00FDch diagnostick\u00FDch n\u00E1dorov\u00FDch marker\u016F. Mo\u017Enosti sou\u010Dasn\u00E9ho i perspektivn\u00EDho u\u017Eit\u00ED terapeutick\u00FDch prost\u0159edk\u016F zam\u011B\u0159en\u00FDch na telomer\u00E1zov\u00FD komplex jsou uvedeny ve stru\u010Dn\u00E9m p\u0159ehledu." . . "Telomery, telomer\u00E1zov\u00FD komplex a kolorekt\u00E1ln\u00ED karcinom"@cs . . "Zvy\u0161uj\u00EDc\u00ED se incidence n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED, zejm\u00E9na malignit gastrointestin\u00E1ln\u00EDho traktu je zaznamen\u00E1na nejen v \u010Cesk\u00E9 republice, ale i celosv\u011Btov\u011B. Jsou st\u00E1le hled\u00E1ny spolehliv\u00E9 diagnostick\u00E9 postupy umo\u017E\u0148uj\u00EDc\u00ED \u010Dasnou detekci n\u00E1dorov\u00E9ho procesu. Jedn\u00EDm z nich je telomer\u00E1zov\u00FD enzymatick\u00FD komplex, kter\u00FD se uplat\u0148uje v n\u00E1dorov\u00E9 transformaci a v rozvoji kancerogeneze. Zv\u00FD\u0161en\u00E1 exprese telomer\u00E1zy je prokazateln\u00E1 a\u017E u 90% malign\u00EDch n\u00E1dor\u016F. Uv\u00E1d\u00EDme proto mo\u017Enosti pr\u016Fkazu komponent telomer\u00E1zov\u00E9ho komplexu jako u\u017Eite\u010Dn\u00FDch diagnostick\u00FDch n\u00E1dorov\u00FDch marker\u016F. Mo\u017Enosti sou\u010Dasn\u00E9ho i perspektivn\u00EDho u\u017Eit\u00ED terapeutick\u00FDch prost\u0159edk\u016F zam\u011B\u0159en\u00FDch na telomer\u00E1zov\u00FD komplex jsou uvedeny ve stru\u010Dn\u00E9m p\u0159ehledu."@cs . "Telomeres, telomerase and colorectal cancer"@en . . "1213-323X" . "CZ - \u010Cesk\u00E1 republika" . . . "Telomeres, telomerase and colorectal cancer"@en . "503259" . "P(1A8651), S" . "1"^^ . . "RIV/00216208:11120/06:00002191!RIV11-MZ0-11120___" . . .