"Metabolic liver function in patients with chronic heart failure"@en . "6"^^ . . "CZ - \u010Cesk\u00E1 republika" . "477971" . . "M\u00E1lek, Filip" . "RIV/00216208:11120/06:00001428!RIV09-MSM-11120___" . "Metabolic liver function in patients with chronic heart failure"@en . "3"^^ . . "Hodnocen\u00ED metabolick\u00E9 jatern\u00ED funkce u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm"@cs . "6"^^ . "Hodnocen\u00ED metabolick\u00E9 jatern\u00ED funkce u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm"@cs . "0010-8650" . "Liver test abnormalities have a prognostic value in patients with chronic heart failure. While the diagnosis of liver damage is based on data from laboratory investigations, routine biochemistry is not sensitive enough to assess the complex processes occurring in hepatocytes. In hepatology, the methacetin breath test is used for exact measurement of microsomal hepatocyte function. No systematic study of metabolic liver function has been conducted to date in patients with chronic heart failure (CHF). A pilot study of patients with systolic heart failure showed significantly impaired metabolic liver function in patients with uncontrolled chronic heart failure. The degree of damage in these patients was consistent with the decrease in microsomal hepatocyte function in liver cirrhosis patients. By contrast, in patients with stable CHF, the metabolic function was assessed as normal and comparable with that in a control group"@en . "Sedl\u00E1kov\u00E1, Milu\u0161ka" . "Hor\u00E1k, Ji\u0159\u00ED" . . "10" . "[5D4072092B53]" . . . . "Hodnocen\u00ED metabolick\u00E9 jatern\u00ED funkce u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm" . . "11120" . . "Kr\u00E1tk\u00E1, Karol\u00EDna" . "Abnormality jatern\u00EDch test\u016F maj\u00ED u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm prognostick\u00FD v\u00FDznam. Diagn\u00F3za jatern\u00EDho po\u0161kozen\u00ED je zalo\u017Eena na v\u00FDsledku laboratorn\u00EDch vy\u0161et\u0159en\u00ED, av\u0161ak rutinn\u00ED biochemick\u00E1 vy\u0161et\u0159en\u00ED nejsou dostate\u010Dn\u016F senzitivn\u00ED pro hodnocen\u00ED komplexn\u00EDch d\u016Fj\u016F, kter\u00E9 se odehr\u00E1vaj\u00ED v hepatocytech. V hepatologii je pou\u017E\u00EDv\u00E1n pro p\u0159esn\u00E9 m\u016F\u0159en\u00ED mikrosom\u00E1ln\u00ED funkce hepatocyt\u016F dechov\u00FD test s methacetinem. Metabolick\u00E9 jatern\u00ED funkce p\u0159i pou\u017Eit\u00ED methacetinu u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm (CHSS) nebyly dosud systematicky studov\u00E1ny. V pilotn\u00ED studii pacient\u016F se systolick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm bylo zji\u0161t\u011Bno v\u00FDznamn\u00E9 naru\u0161en\u00ED metabolick\u00E9 jatern\u00ED funkce u pacient\u016F s dekompenzac\u00ED chronick\u00E9ho srde\u010Dn\u00EDho selh\u00E1n\u00ED. \u00DArove\u0148 po\u0161kozen\u00ED byla u t\u011Bchto jedinc\u016F srovnateln\u00E1 se sn\u00ED\u017Een\u00EDm mikrosom\u00E1ln\u00ED funkce hepatocyt\u016F u pacient\u016F s jatern\u00ED cirh\u00F3zou. Naproti tomu u pacient\u016F se stabiln\u00EDm CHSS byla metabolick\u00E1 funkce hodnocena jako norm\u00E1ln\u00ED a srovnateln\u00E1 s kontroln\u00ED skupinou"@cs . . "48" . . . "Vr\u00E1nov\u00E1, Jana" . "Hendrichov\u00E1, Milu\u0161e" . "Cor et Vasa" . . . "Z(MSM0021620814)" . . . "Hodnocen\u00ED metabolick\u00E9 jatern\u00ED funkce u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm" . . "Abnormality jatern\u00EDch test\u016F maj\u00ED u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm prognostick\u00FD v\u00FDznam. Diagn\u00F3za jatern\u00EDho po\u0161kozen\u00ED je zalo\u017Eena na v\u00FDsledku laboratorn\u00EDch vy\u0161et\u0159en\u00ED, av\u0161ak rutinn\u00ED biochemick\u00E1 vy\u0161et\u0159en\u00ED nejsou dostate\u010Dn\u016F senzitivn\u00ED pro hodnocen\u00ED komplexn\u00EDch d\u016Fj\u016F, kter\u00E9 se odehr\u00E1vaj\u00ED v hepatocytech. V hepatologii je pou\u017E\u00EDv\u00E1n pro p\u0159esn\u00E9 m\u016F\u0159en\u00ED mikrosom\u00E1ln\u00ED funkce hepatocyt\u016F dechov\u00FD test s methacetinem. Metabolick\u00E9 jatern\u00ED funkce p\u0159i pou\u017Eit\u00ED methacetinu u pacient\u016F s chronick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm (CHSS) nebyly dosud systematicky studov\u00E1ny. V pilotn\u00ED studii pacient\u016F se systolick\u00FDm srde\u010Dn\u00EDm selh\u00E1n\u00EDm bylo zji\u0161t\u011Bno v\u00FDznamn\u00E9 naru\u0161en\u00ED metabolick\u00E9 jatern\u00ED funkce u pacient\u016F s dekompenzac\u00ED chronick\u00E9ho srde\u010Dn\u00EDho selh\u00E1n\u00ED. \u00DArove\u0148 po\u0161kozen\u00ED byla u t\u011Bchto jedinc\u016F srovnateln\u00E1 se sn\u00ED\u017Een\u00EDm mikrosom\u00E1ln\u00ED funkce hepatocyt\u016F u pacient\u016F s jatern\u00ED cirh\u00F3zou. Naproti tomu u pacient\u016F se stabiln\u00EDm CHSS byla metabolick\u00E1 funkce hodnocena jako norm\u00E1ln\u00ED a srovnateln\u00E1 s kontroln\u00ED skupinou" . . . "RIV/00216208:11120/06:00001428" . . . "chronic heart failure; liver function; breath test; Methacetin"@en .