. "8" . . . . . "Postgradu\u00E1ln\u00ED medic\u00EDna" . . "Arenberger, Petr" . "RIV/00216208:11120/06:00001255" . "6"^^ . "1"^^ . "2" . "Prevence a l\u00E9\u010Dba ko\u017En\u00EDch pigmentov\u00FDch n\u00E1dor\u016F" . . "P(1A8243)" . "Prevence a l\u00E9\u010Dba ko\u017En\u00EDch pigmentov\u00FDch n\u00E1dor\u016F"@cs . "CZ - \u010Cesk\u00E1 republika" . "Prevention and treatment of skin pigmented tumors"@en . "[2B08C99862A7]" . "1"^^ . . "11120" . . . "Prevention and treatment of skin pigmented tumors"@en . "The prognosis of patients with malignant melanoma is significantly dependent on tumor thickness and this is a reason why the early diagnostics is essential for the favourable disease outcome. Accuracy of the melanoma clinical diagnostics has been enhanced by introduction of dermoscopy, particularly by its digital form, which is able to improve the accuracy of the clinical decision for more than 25 % in a trained dermatologist. The malignant melanoma mortality rate has been remaining constant since eighties of the 20th century, therefore, research into new substances which should be able to prolong the patiens\u00B4s survival in metastatic stage is in progress"@en . . "1212-4184" . . . "Progn\u00F3za pacienta s malign\u00EDm melanomem je v\u00FDznamn\u011B z\u00E1visl\u00E1 na tlou\u0161\u0165ce tumoru, proto je v\u010Dasn\u00E1 diagnostika nezbytn\u00FDm p\u0159edpokladem p\u0159\u00EDzniv\u00E9ho pr\u016Fb\u011Bhu onemocn\u011Bn\u00ED. Zv\u00FD\u0161en\u00ED p\u0159esnosti klinick\u00E9 diagn\u00F3zy melanomu p\u0159inesla dermatoskopie, p\u0159edev\u0161\u00EDm pak ve sv\u00E9 digit\u00E1ln\u00ED podob\u011B, kter\u00E1 zlep\u0161\u00ED \u0161kolen\u00E9mu dermatologovi p\u0159esnost klinick\u00E9 diagn\u00F3zy o v\u00EDce ne\u017E 25 %. Mortalita na malign\u00ED melanom z\u016Fst\u00E1v\u00E1 od 80. let 20. stolet\u00ED konstantn\u00ED, a proto je velk\u00FD tlak na objeven\u00ED nov\u00FDch l\u00E1tek, kter\u00E9 by prodlou\u017Eily p\u0159e\u017E\u00EDv\u00E1n\u00ED pacient\u016F v metastatick\u00E9m st\u00E1diu"@cs . "Prevence a l\u00E9\u010Dba ko\u017En\u00EDch pigmentov\u00FDch n\u00E1dor\u016F"@cs . "malignant melanoma; prognosis; incidence; dermoscopy; sentinel lymph node; immunotherapy; chemotherapy; follow up"@en . "RIV/00216208:11120/06:00001255!RIV09-MZ0-11120___" . . . . . . . . "494364" . "Progn\u00F3za pacienta s malign\u00EDm melanomem je v\u00FDznamn\u011B z\u00E1visl\u00E1 na tlou\u0161\u0165ce tumoru, proto je v\u010Dasn\u00E1 diagnostika nezbytn\u00FDm p\u0159edpokladem p\u0159\u00EDzniv\u00E9ho pr\u016Fb\u011Bhu onemocn\u011Bn\u00ED. Zv\u00FD\u0161en\u00ED p\u0159esnosti klinick\u00E9 diagn\u00F3zy melanomu p\u0159inesla dermatoskopie, p\u0159edev\u0161\u00EDm pak ve sv\u00E9 digit\u00E1ln\u00ED podob\u011B, kter\u00E1 zlep\u0161\u00ED \u0161kolen\u00E9mu dermatologovi p\u0159esnost klinick\u00E9 diagn\u00F3zy o v\u00EDce ne\u017E 25 %. Mortalita na malign\u00ED melanom z\u016Fst\u00E1v\u00E1 od 80. let 20. stolet\u00ED konstantn\u00ED, a proto je velk\u00FD tlak na objeven\u00ED nov\u00FDch l\u00E1tek, kter\u00E9 by prodlou\u017Eily p\u0159e\u017E\u00EDv\u00E1n\u00ED pacient\u016F v metastatick\u00E9m st\u00E1diu" . "Prevence a l\u00E9\u010Dba ko\u017En\u00EDch pigmentov\u00FDch n\u00E1dor\u016F" .