. "RIV/00216208:11120/06:00000669" . . "%22Proteinase-activated%22 receptor-2 (PAR-2) is a G protein-coupled transmembrane receptor with seven transmembrane domains activated by trypsin. It has been shown in the pancreatic tissue that PAR-2 is involved in duct/acinary cells secretion, arterial tonus regulation and capillary liquid content turnover under physiological conditions. These above mentioned structures play an important role during the development of acute pancreatitis and are profoundly influenced by a high concentration of trypsin enzyme after its secretion into the interstitial tissue from the basolateral aspect of acinar cells. Among the other factors, it is the increase of interstitial trypsin concentration followed rapidly by PAR-2 action on pancreatic vascular smooth muscle cells that initiates ischemic changes in pancreatic parenchyma and that finally leads to necrosis of the pancreas. Consequent reperfusion perpetuates changes leading to the acute pancreatitis development. On the contrary, PAR-2 action on both exocrine a" . "Olej\u00E1r, T." . "Mat\u011Bj, R." . "Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde"@en . . . . "5" . "464106" . . "Physiological Research" . . . "11120" . "1"^^ . "000241910900001" . "[770D15BA9C99]" . "3"^^ . "Housa, Daniel" . "CZ - \u010Cesk\u00E1 republika" . . . . "8"^^ . "%22Proteinase-activated%22 receptor-2 (PAR-2) is a G protein-coupled transmembrane receptor with seven transmembrane domains activated by trypsin. It has been shown in the pancreatic tissue that PAR-2 is involved in duct/acinary cells secretion, arterial tonus regulation and capillary liquid content turnover under physiological conditions. These above mentioned structures play an important role during the development of acute pancreatitis and are profoundly influenced by a high concentration of trypsin enzyme after its secretion into the interstitial tissue from the basolateral aspect of acinar cells. Among the other factors, it is the increase of interstitial trypsin concentration followed rapidly by PAR-2 action on pancreatic vascular smooth muscle cells that initiates ischemic changes in pancreatic parenchyma and that finally leads to necrosis of the pancreas. Consequent reperfusion perpetuates changes leading to the acute pancreatitis development. On the contrary, PAR-2 action on both exocrine a"@en . "55" . . . "Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde"@en . "S, V" . . "0862-8408" . "RIV/00216208:11120/06:00000669!RIV09-MSM-11120___" . "Akutn\u00ED pankreatitida: protein\u00E1zou aktivovan\u00FD receptor jako Dr. Jekyll a pan Hyde"@cs . "Auto\u0159i popisuj\u00ED akutn\u00ED pankreatitidu a ukazuj\u00ED protein\u00E1zou aktivovan\u00FD receptor jako Dr. Jekylla a pan Hyda"@cs . "Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde" . "Akutn\u00ED pankreatitida: protein\u00E1zou aktivovan\u00FD receptor jako Dr. Jekyll a pan Hyde"@cs . "Acute pancreatitis: Proteinase-activated receptor-2 as Dr. Jekyll and Mr. Hyde" . "PAR-2; acute pancreatitis; trypsin"@en . .