"Havelkov\u00E1, H." . "8"^^ . . "000237100100005" . . "leishmaniasis; host response; gene effect"@en . . "Genetick\u00E1 vn\u00EDmavost k leishmani\u00E1ze u my\u0161i: \u010Dty\u0159i nov\u00E9 lokusy a funk\u010Dn\u00ED heterogenita genetick\u00FDch efekt\u016F"@cs . "476899" . "RIV/00216208:11120/06:00000506" . "Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects" . "Z(AV0Z50520514)" . "1"^^ . "Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects"@en . "[EE85341EDD2F]" . . . "1466-4879" . "7" . . "14"^^ . "Projevy leishmaniosy u \u010Dlov\u011Bka jsou pozorov\u00E1ny v rozsahu od subklinick\u00FDch po projevy rozs\u00E1hl\u00E9ho syst\u00E9mov\u00E9ho onemocn\u011Bn\u00ED. P\u0159\u00ED\u010Diny t\u011Bchto odli\u0161nost\u00ED dosud nejsou zn\u00E1my. Analyzovali jsme symptomatologii leishmaniosy u my\u0161\u00ED tak, \u017Ee jsme monitorovali v\u00FDvoj lez\u00ED, hepatomegalii, splenomegalii a sedm imunologick\u00FDch parametr\u016F. Objevili jsme 17 genov\u00FDch lokus\u016F odpov\u011Bdi na Leishmania major (Lmr), kter\u00E9 kontroluj\u00ED projevy infekce. P\u0159ekvapiv\u011B jednotliv\u00E9 Lmr lokusy kontrolovaly 13 r\u016Fzn\u00FDch kombinac\u00ED patologick\u00FDch a imunologick\u00FDch symptom\u016F. Tento n\u00E1lez roz\u0161i\u0159uje n\u00E1zor na odpov\u011B\u010F hostitele na infekci. Na\u0161e pr\u00E1ce ukazuje, \u017Ee odpov\u011B\u010F na infekci je \u0159\u00EDzena mnoha geny, z nich\u017E ka\u017Ed\u00FD kontroluje r\u016Fzn\u00E9 skupiny org\u00E1nov\u011B specifick\u00FDch a syst\u00E9mov\u00FDch efekt\u016F."@cs . . . . "RIV/00216208:11120/06:00000506!RIV09-AV0-11120___" . . . "Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects"@en . . "Genes and Immunity" . "Genetick\u00E1 vn\u00EDmavost k leishmani\u00E1ze u my\u0161i: \u010Dty\u0159i nov\u00E9 lokusy a funk\u010Dn\u00ED heterogenita genetick\u00FDch efekt\u016F"@cs . "Symptoms of human leishmaniasis range from subclinical to extensive systemic disease, but the basis of these variations is unknown. We analyzed the symptomatology of leishmaniasis in mice by monitoring skin lesions, hepatomegaly, splenomegaly and seven immunological parameters. We detected and mapped 17 Leishmania major response (Lmr) gene loci that control the symptoms of infection. Surprisingly, the individual Lmr loci control 13 different combinations of pathological and immunological symptoms. These findings extend the paradigm for the genetics of host response to infection to include numerous genes, each controlling a different set of organ-specific and systemic effects." . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects" . "11120" . "Lipoldov\u00E1, Marie" . . "Symptoms of human leishmaniasis range from subclinical to extensive systemic disease, but the basis of these variations is unknown. We analyzed the symptomatology of leishmaniasis in mice by monitoring skin lesions, hepatomegaly, splenomegaly and seven immunological parameters. We detected and mapped 17 Leishmania major response (Lmr) gene loci that control the symptoms of infection. Surprisingly, the individual Lmr loci control 13 different combinations of pathological and immunological symptoms. These findings extend the paradigm for the genetics of host response to infection to include numerous genes, each controlling a different set of organ-specific and systemic effects."@en . . "3" .