. . "The effects of selective antagonist of serotonin 5-HT2C receptor SB242084 on rats locomotion in animal models of psychoses"@en . "Vrajov\u00E1, Monika" . . . . "V na\u0161\u00ED experiment\u00E1ln\u00ED pr\u00E1ci jsme hodnotili \u00FA\u010Dinek selektivn\u00EDho, hematoencefalickou barierou pronikaj\u00EDc\u00EDho antagonisty serotoninov\u00FDch 5-HT2C receptor\u016F l\u00E1tky SB-242084. V anim\u00E1ln\u00EDch modelech psych\u00F3z vyvolan\u00E9m akutn\u00EDm pod\u00E1n\u00EDm l\u00E1tek MK-801 (glutam\u00E1tergn\u00ED model), psilocinu a LSD (serotonergn\u00ED modely) jsme hodnotili zm\u011Bny v lokomoci indukovan\u00E9 p\u0159id\u00E1n\u00EDm l\u00E1tky SB-242084. Experimenty jsme prov\u00E1d\u011Bli na dosp\u011Bl\u00EDch samc\u00EDch potkan\u016F kmene Wistar. V testu otev\u0159en\u00E9ho pole jsme hodnotili jsme celkovou lokomoci, kterou zv\u00ED\u0159ata ub\u011Bhla za dobu 30 minut. MK-801 vyvolalo u zv\u00ED\u0159at hyperlokomoci, psilocin hypolokomoci a LSD m\u011Blo m\u00EDrn\u00FD nesignifikantn\u00ED hypolokomo\u010Dn\u00ED \u00FA\u010Dinek. SB-242084 prodlu\u017Eovalo lokomoci v p\u0159\u00EDpad\u011B MK-801 a psilocinu. Potenciace hyperlokomoce po MK-801 byla v\u00EDce jak dvoun\u00E1sobn\u00E1, u psilocinu SB-242084 normalizovalo lokomoci na \u00FArove\u0148 kontroln\u00EDch zv\u00ED\u0159at. V p\u0159\u00EDpad\u011B LSD jsme pozorovali bif\u00E1zick\u00FD \u00FA\u010Dinek SB-242084, kdy u ni\u017E\u0161\u00ED d\u00E1vky do\u0161lo k signifikantn\u00ED potenciaci hypolokomoce, u vy\u0161\u0161\u00ED d\u00E1vky byl naopak n\u00E1znak opa\u010D"@cs . "V na\u0161\u00ED experiment\u00E1ln\u00ED pr\u00E1ci jsme hodnotili \u00FA\u010Dinek selektivn\u00EDho, hematoencefalickou barierou pronikaj\u00EDc\u00EDho antagonisty serotoninov\u00FDch 5-HT2C receptor\u016F l\u00E1tky SB-242084. V anim\u00E1ln\u00EDch modelech psych\u00F3z vyvolan\u00E9m akutn\u00EDm pod\u00E1n\u00EDm l\u00E1tek MK-801 (glutam\u00E1tergn\u00ED model), psilocinu a LSD (serotonergn\u00ED modely) jsme hodnotili zm\u011Bny v lokomoci indukovan\u00E9 p\u0159id\u00E1n\u00EDm l\u00E1tky SB-242084. Experimenty jsme prov\u00E1d\u011Bli na dosp\u011Bl\u00EDch samc\u00EDch potkan\u016F kmene Wistar. V testu otev\u0159en\u00E9ho pole jsme hodnotili jsme celkovou lokomoci, kterou zv\u00ED\u0159ata ub\u011Bhla za dobu 30 minut. MK-801 vyvolalo u zv\u00ED\u0159at hyperlokomoci, psilocin hypolokomoci a LSD m\u011Blo m\u00EDrn\u00FD nesignifikantn\u00ED hypolokomo\u010Dn\u00ED \u00FA\u010Dinek. SB-242084 prodlu\u017Eovalo lokomoci v p\u0159\u00EDpad\u011B MK-801 a psilocinu. Potenciace hyperlokomoce po MK-801 byla v\u00EDce jak dvoun\u00E1sobn\u00E1, u psilocinu SB-242084 normalizovalo lokomoci na \u00FArove\u0148 kontroln\u00EDch zv\u00ED\u0159at. V p\u0159\u00EDpad\u011B LSD jsme pozorovali bif\u00E1zick\u00FD \u00FA\u010Dinek SB-242084, kdy u ni\u017E\u0161\u00ED d\u00E1vky do\u0161lo k signifikantn\u00ED potenciaci hypolokomoce, u vy\u0161\u0161\u00ED d\u00E1vky byl naopak n\u00E1znak opa\u010D" . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . "\u00DA\u010Dinky selektivn\u00EDho antagonisty serotoninov\u00E9ho 5-HT2C receptoru SB242084 na lokomoci potkana v anim\u00E1ln\u00EDch modelech psych\u00F3z" . . . "Psychiatrie" . . "16-20" . "RIV/00216208:11120/06:00000043" . "\u00DA\u010Dinky selektivn\u00EDho antagonisty serotoninov\u00E9ho 5-HT2C receptoru SB242084 na lokomoci potkana v anim\u00E1ln\u00EDch modelech psych\u00F3z" . . "Suppl. 3" . . "P(1M0517)" . . "\u00DA\u010Dinky selektivn\u00EDho antagonisty serotoninov\u00E9ho 5-HT2C receptoru SB242084 na lokomoci potkana v anim\u00E1ln\u00EDch modelech psych\u00F3z"@cs . . "RIV/00216208:11120/06:00000043!RIV07-MSM-11120___" . "CZ - \u010Cesk\u00E1 republika" . "\u00DA\u010Dinky selektivn\u00EDho antagonisty serotoninov\u00E9ho 5-HT2C receptoru SB242084 na lokomoci potkana v anim\u00E1ln\u00EDch modelech psych\u00F3z"@cs . "504769" . . . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . "3"^^ . . . . . "11120" . "SB-242084; MK-801 (dizocilpin); LSD (N,N-diethyllysergamide); psilocin (4-hydroxy-N,N-dimethyltryptamine); serotonin; locomotion; rats"@en . . . "Buben\u00EDkov\u00E1-Vale\u0161ov\u00E1, V." . "5"^^ . . "10" . "1211-7579" . . "Nov\u00E1k, T." . "[77DD3D1D1B84]" . "5"^^ . . "In our experiments we have evaluated the effect of selective brain penetrant serotonin 5-HT2C antagonist SB-242084. We have concentrated on the effects of SB-242084 on characteristic locomotor changes in animal models of psychosis induced by acute administration of MK-801 (glutamatergic model), psilocin and LSD (serotonergic models). Experiments were carried out on adult male Wistar rats. We have evaluated total locomotion of animals within 30 minutes in the open field test. MK-801 alone induced pronounced hyperlcomotion, psilocin hypolocomotion and LSD had slight non-significant hypolocomotor effect. SB-242084 prolonged locomotion in MK-801 and psilocin treated animals. Potentiation of hyperlocomotion induced by MK-801 was almost twice, however in psilocin treated animals normalized locomotion to control level. In the case of LSD we have seen biphasic effect of SB-242084, while with the lower dose hypolocomotion was potentiated to significant level, with the higher dose opposite trend was indicate"@en . "The effects of selective antagonist of serotonin 5-HT2C receptor SB242084 on rats locomotion in animal models of psychoses"@en .