. "4"^^ . . . . "OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5+/-19.1 years) and 8 women (mean age 31.3+/-8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated w" . . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . . "Z(MSM0021620816)" . . . "0172-780X" . "OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5+/-19.1 years) and 8 women (mean age 31.3+/-8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated w"@en . . . "RIV/00216208:11120/06:00000030" . "6" . "[3645705037CE]" . "risperidone; prolactinemia; depression; anxiety; side effect; endocrinology"@en . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . "Neuroendocrinology Letters" . . "483680" . "4"^^ . "27" . "Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia"@en . "11120" . "4"^^ . "Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia"@en . "Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia" . "Kope\u010Dek, Miloslav" . "Augmentace antidepresiv \u010Di anxiolytik n\u00EDzk\u00FDmi d\u00E1vkami risperidonu je spojena s hyperprolaktinemi\u00ED"@cs . . "Augmentace antidepresiv \u010Di anxiolytik n\u00EDzk\u00FDmi d\u00E1vkami risperidonu je spojena s hyperprolaktinemi\u00ED"@cs . . . "Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia" . "RIV/00216208:11120/06:00000030!RIV07-MSM-11120___" . . . . "Bare\u0161, Martin" . "Mohr, Pavel" . . . "803-806" . . . "\u00DAvod: Risperidon v antipsychotick\u00FDch d\u00E1vk\u00E1ch vede k hyperprolaktin\u00E9mii. C\u00EDlem t\u00E9to studie bylo objasnit, zdali tak\u00E9 n\u00EDzk\u00E9 d\u00E1vky risperidonu (0,5-2 mg/denn\u011B) p\u0159idan\u00E9 k antidepresiv\u016Fm nebo anxiolytik\u00E1m zp\u016Fsobuj\u00ED hyperprolaktin\u00E9mii. Metody: Hladina prolaktinu byla m\u011B\u0159ena u 4 mu\u017E\u016F (pr\u016Fm. v\u011Bk 49,5+/-19,1 let) a 8 \u017Een (pr\u016Fm. v\u011Bk 31,3+/-8,2 let) hospitalizovan\u00FDch pro depresivn\u00ED \u010Di \u00FAzkostn\u00E9 poruchy. Pacienti byli l\u00E9\u010Deni risperidonem (medi\u00E1n denn\u00ED d\u00E1vky 1,25 mg). Risperidon byl pou\u017Eit jako augmenta\u010Dn\u00ED l\u00E9\u010Dba antidepresiv (n=8), anxiolytik (n=6) a thymostabiliz\u00E9r\u016F (n=2) po dobu medi\u00E1nu 15,5 dn\u016F. V\u00FDsledky: 11 z 12 pacient\u016F m\u011Blo hyperprolaktin\u00E9mii. Medi\u00E1n plasmatick\u00E9 hladiny prolaktinu byl 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Byla zji\u0161t\u011Bna signifikatn\u00ED korelace mezi denn\u00ED d\u00E1vkou risperidonu a plasmatickou hladinou prolaktinu (Spearmanovo R=0,655; p=0,02). U dvou \u017Een se objevila galaktorrhea a u jedn\u00E9 amenorrhea. Z\u00E1v\u011Br: I mal\u00E9 d\u00E1vky risperidonu pou\u017Eit\u00E9 jako augmentace antidepresiv \u010Di benzodiazepin\u016F jsou spojen\u00E9"@cs .