. "587-594" . . "27" . "[4A779ED17345]" . "0172-780X" . . . "13"^^ . . . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . "Region\u00E1ln\u00ED metabolismus mozku jako prediktor v\u00FDkonu na test cesty u schizofrenie. 18FDG PET kovaria\u010Dn\u00ED studie"@cs . "9"^^ . "RIV/00216208:11120/06:00000024!RIV07-MSM-11120___" . . "Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysis we compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better performance in the TMT" . "496873" . "7"^^ . . . "Trail Making Test; Positron emission tomography (PET); 18FDG; schizophrenia; cognitive dysfunction"@en . . "Nov\u00E1k, T." . "RIV/00216208:11120/06:00000024" . . . "Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysis we compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better performance in the TMT"@en . "Ti\u0161lerov\u00E1, Barbora" . "\u0160paniel, Filip" . "V\u00FDchodiska: S c\u00EDlem indikovat funk\u010Dn\u011B anatomick\u00FD substr\u00E1t kognitivn\u00ED dysfunkce u schizofrenie jsme hodnotili vztah mezi klidov\u00FDm metabolismem mozku a v\u00FDkonem p\u0159i Testu cesty (TMT). Nejprve jsme porovnali v\u00FDkon v \u010D\u00E1sti A a B Testu cesty mezi pacienty trp\u00EDc\u00EDc\u00EDmi schizofreni\u00ED a kontroln\u00EDmi subjekty. Klidov\u00FD metabolismus mozku byl vy\u0161et\u0159ov\u00E1n 18FDG pozitronovou emisn\u00ED tomografi\u00ED (PET) jako indik\u00E1tor synaptick\u00E9 denzity. Metody: Data z 18FDG PET byla analyzov\u00E1na pomoc\u00ED SPM99 s \u010D\u00E1stmi A a B Testu cesty jako kovari\u00E1ty (pL0.001). V\u00FDsledky: Pacienti se schizofreni\u00ED (N=42) m\u011Bli hor\u0161\u00ED v\u00FDkon v obou \u010D\u00E1stech Testu cesty v porovn\u00E1n\u00ED s kontrolami (N=42). U subjekt\u016F se schizofreni\u00ED nepredikovala 18FDG PET v\u00FDkon v \u010D\u00E1sti A Testu cesty (psychomotorick\u00E1 rychlost), ale predikovala ho pro \u010D\u00E1st B Testu cesty (set-shifting a flexibilita). Vychyt\u00E1v\u00E1n\u00ED 18FDG v horn\u00EDm, st\u0159edn\u00EDm a doln\u00EDm front\u00E1ln\u00EDm gyru bilater\u00E1ln\u011B bylo asociov\u00E1no s lep\u0161\u00EDm v\u00FDkonem v \u010D\u00E1sti B Testu cesty. Negativn\u00ED kovariace mezi 18FDG vychyt\u00E1v\u00E1n\u00EDm a \u010Dasem str\u00E1ven\u00FDm"@cs . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . . "5" . . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . . "Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study" . . "Kl\u00EDrov\u00E1, Monika" . "Dockery, Colleen" . . "11120" . "Kope\u010Dek, Miloslav" . . . . "Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study"@en . "Neuroendocrinology Letters" . . "Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study" . "H\u00F6schl, Cyril" . "Region\u00E1ln\u00ED metabolismus mozku jako prediktor v\u00FDkonu na test cesty u schizofrenie. 18FDG PET kovaria\u010Dn\u00ED studie"@cs . . . . "P(1M0517), P(NR8792), Z(MZ0PCP2005)" . "Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study"@en . . .