"P(1M0517), P(NL7684)" . . "Serotonergn\u00ED syst\u00E9m je jedn\u00EDm z kl\u00ED\u010Dov\u00FDch neurotrasmiterov\u00FDch syst\u00E9m\u016F ovliv\u0148ovan\u00FD antipsychotiky. N\u011Bkter\u00E1 antipsychotika (clozapin, olanzapin) vykazuj\u00ED vysokou afinitu k serotoninov\u00FDm receptor\u016Fm typu 5-HT2A a 5-HT 2C. C\u00EDlem t\u00E9to pr\u00E1ce bylo zjistit roli t\u011Bchto receptor\u016F ve zpracov\u00E1n\u00ED informac\u00ED v anim\u00E1ln\u00EDm farmakologick\u00E9m modelu schizofrenii podobn\u00E9ho chov\u00E1n\u00ED vyvolan\u00E9m akutn\u00EDm pod\u00E1n\u00EDm nekompetitivn\u00EDho antagonisty N-methyl-D-aspart\u00E1tov\u00E9ho (NMDA) receptoru - dizocilpinu (MK-801). Pou\u017Eili jsme antagonisty serotoninov\u00FDch 5-HT2A/2C (ritanserin) a 5-HT2C (SB 242084) receptor\u016F a sledovali jsme jejiich vliv na deficit ve zpracov\u00E1n\u00ED informac\u00ED po pod\u00E1n\u00ED MK-801. \u00DArove\u0148 zpracov\u00E1n\u00ED informac\u00ED byla m\u011B\u0159ena testem prepulzn\u00ED inhibice \u00FAlekov\u00E9 reakce (PPI) u potkana. Pod\u00E1n\u00ED MK-801 vedlo v na\u0161em modelu k deficitu v PPI. Ritanserin zlep\u0161oval deficit v PPI zp\u016Fsoben\u00FD MK-801, zat\u00EDmco SB 242084 na deficit vliv nem\u011Blo." . "Effect of Serotonin 5-HT2A/2C Receptors on Rat Behavior in Animal Model of Schizophrenia-like Behavior"@en . . . "Suppl. 3" . . . "\u00DA\u010Dinek antagonist\u016F serotoninov\u00FDch 5-HT2A/2C receptor\u016F na chov\u00E1n\u00ED potkana v anim\u00E1ln\u00EDm modelu schizofrenii podobn\u00E9m chov\u00E1n\u00ED" . "RIV/00216208:11120/05:00009600!RIV06-MSM-11120___" . "The serotonergic system is one of the key neurotrasmitter systems affected by the effects of antipsychotic drugs. Some antipsychotics (clozapine, olanzapine) show high affinities at serotonin 5-HT2A a 5-HT2C receptors. The aim of this study was to evaluate the role of these receptor subtypes in information processing in pharmacological animal model of schizophrenia-like behavior induced by acute administration of non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist - dizocilpine (MK-801). We used a serotonin 5-HT2A/2C receptor antagonist (ritanserin) and a selective, brain penetrant, serotonin 5-HT2C receptor antagonist (SB 242084). We have concentrated on how they affect deficits in information processing induced by MK-801."@en . "\u00DA\u010Dinek antagonist\u016F serotoninov\u00FDch 5-HT2A/2C receptor\u016F na chov\u00E1n\u00ED potkana v anim\u00E1ln\u00EDm modelu schizofrenii podobn\u00E9m chov\u00E1n\u00ED"@cs . . . "Psychiatrie" . "Buben\u00EDkov\u00E1, V\u011Bra" . "11120" . "1211-7579" . "Effect of Serotonin 5-HT2A/2C Receptors on Rat Behavior in Animal Model of Schizophrenia-like Behavior"@en . . . . "\u00DA\u010Dinek antagonist\u016F serotoninov\u00FDch 5-HT2A/2C receptor\u016F na chov\u00E1n\u00ED potkana v anim\u00E1ln\u00EDm modelu schizofrenii podobn\u00E9m chov\u00E1n\u00ED" . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . . "4"^^ . . "[B509D0FE2422]" . . . . . "\u00DA\u010Dinek antagonist\u016F serotoninov\u00FDch 5-HT2A/2C receptor\u016F na chov\u00E1n\u00ED potkana v anim\u00E1ln\u00EDm modelu schizofrenii podobn\u00E9m chov\u00E1n\u00ED"@cs . "CZ - \u010Cesk\u00E1 republika" . "25;28" . . "2"^^ . "547635" . . "Serotonergn\u00ED syst\u00E9m je jedn\u00EDm z kl\u00ED\u010Dov\u00FDch neurotrasmiterov\u00FDch syst\u00E9m\u016F ovliv\u0148ovan\u00FD antipsychotiky. N\u011Bkter\u00E1 antipsychotika (clozapin, olanzapin) vykazuj\u00ED vysokou afinitu k serotoninov\u00FDm receptor\u016Fm typu 5-HT2A a 5-HT 2C. C\u00EDlem t\u00E9to pr\u00E1ce bylo zjistit roli t\u011Bchto receptor\u016F ve zpracov\u00E1n\u00ED informac\u00ED v anim\u00E1ln\u00EDm farmakologick\u00E9m modelu schizofrenii podobn\u00E9ho chov\u00E1n\u00ED vyvolan\u00E9m akutn\u00EDm pod\u00E1n\u00EDm nekompetitivn\u00EDho antagonisty N-methyl-D-aspart\u00E1tov\u00E9ho (NMDA) receptoru - dizocilpinu (MK-801). Pou\u017Eili jsme antagonisty serotoninov\u00FDch 5-HT2A/2C (ritanserin) a 5-HT2C (SB 242084) receptor\u016F a sledovali jsme jejiich vliv na deficit ve zpracov\u00E1n\u00ED informac\u00ED po pod\u00E1n\u00ED MK-801. \u00DArove\u0148 zpracov\u00E1n\u00ED informac\u00ED byla m\u011B\u0159ena testem prepulzn\u00ED inhibice \u00FAlekov\u00E9 reakce (PPI) u potkana. Pod\u00E1n\u00ED MK-801 vedlo v na\u0161em modelu k deficitu v PPI. Ritanserin zlep\u0161oval deficit v PPI zp\u016Fsoben\u00FD MK-801, zat\u00EDmco SB 242084 na deficit vliv nem\u011Blo."@cs . . "9" . "Effect; Serotonin; 5-HT2A/2C; Receptors; Behavior; Animal; Model; Schizophrenia-like; Behavior"@en . . . . "2"^^ . "RIV/00216208:11120/05:00009600" .