"Novel genotyping and statistical tools have led to mapping of numerous QTL loci for multigenic traits that previously could not be detected. The relationships of these QTL families to other QTL families and the functional specialization of their members can now be studied. We have mapped loci controlling activation of T lymphocytes by mitogens and cytokines and their capacity to produce cytokines (Cinda3-5). These novel Cinda loci and the previously mapped Cinda1 locus seem to be located in genomic regions together with other QTL families. The possible relevance of these QTL associations in several different sites of the genome for the immune response, inflammation and tumorigenesis has to be elucidated."@en . "cytokins; autoimmune; controlling lymphocyte; novel loci"@en . . "Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function, and lung tumor susceptibility" . . "Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function, and lung tumor susceptibility"@en . . . . "Novel genotyping and statistical tools have led to mapping of numerous QTL loci for multigenic traits that previously could not be detected. The relationships of these QTL families to other QTL families and the functional specialization of their members can now be studied. We have mapped loci controlling activation of T lymphocytes by mitogens and cytokines and their capacity to produce cytokines (Cinda3-5). These novel Cinda loci and the previously mapped Cinda1 locus seem to be located in genomic regions together with other QTL families. The possible relevance of these QTL associations in several different sites of the genome for the immune response, inflammation and tumorigenesis has to be elucidated." . "Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function, and lung tumor susceptibility"@en . "533339" . . . "Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function, and lung tumor susceptibility" . . "3" . . . . "[519175A801DB]" . "RIV/00216208:11120/05:00002111" . "Lipoldov\u00E1, Marie" . . . "1"^^ . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "0020-7136" . "6"^^ . "4"^^ . "International Journal of Cancer" . "114" . . "RIV/00216208:11120/05:00002111!RIV10-MSM-11120___" . "000227223100009" . . "P(GA310/03/1381), S, Z(AV0Z5052915)" . "Havelkov\u00E1, H." . "11120" . . . "Demant, P." . "Badalov\u00E1, Jana" . .