"512739" . . "Physiological Research" . "Fanta, Jan" . "Fric, M." . . "Waldauf, P." . "000234481000017" . "S" . . . "11120" . "Ned\u00E1vno jsme vyvinuli jednoduchou metodu detekce plasmatick\u00E9 DNA, kter\u00E1 umo\u017En\u00ED rozli\u0161it DNA z nekrotick\u00FDch a apoptotick\u00FDch bun\u011Bk. P\u0159i aplikaci t\u00E9to metody na sm\u00ED\u0161enou populaci kriticky nemocn\u00FDch jsme zjistili, \u017Ee vy\u0161\u0161\u00ED hladiny apoptotick\u00E9 DNA 1. den po p\u0159\u00EDjmu maj\u00ED nemocn\u00ED, u kter\u00FDch se pozd\u011Bji rozvine multiorg\u00E1nov\u00E9 selh\u00E1v\u00E1n\u00ED. Nav\u00EDc, apoptotick\u00E1 DNA p\u0159eva\u017Eovala nad DNA z nekrotick\u00FDch bun\u011Bk u nep\u0159e\u017Eiv\u0161\u00EDch."@cs . "Du\u0161ka, Franti\u0161ek" . "6" . "\u017D\u010F\u00E1rsk\u00FD, Emanuel" . "Apoptosis as an early event in the development of multiple organ failure?"@en . "We have recently developed a simple method of plasma free DNA detection, which enables us to distinguish between apoptotic and genomic (necrotic) DNA. After applying this method to the critically ill, we revealed apoptotic DNA on the day of admission to be higher than later when multiple-organ failure developed. Moreover, apoptotic DNA contributed to total plasma DNA much more than DNA from necrotic cells and its increase predicted future development of multiple-organ failure and death." . "Apoptosis as an early event in the development of multiple organ failure?"@en . . "54" . "CZ - \u010Cesk\u00E1 republika" . . "RIV/00216208:11120/05:00001004!RIV09-MSM-11120___" . "[A91230829340]" . "We have recently developed a simple method of plasma free DNA detection, which enables us to distinguish between apoptotic and genomic (necrotic) DNA. After applying this method to the critically ill, we revealed apoptotic DNA on the day of admission to be higher than later when multiple-organ failure developed. Moreover, apoptotic DNA contributed to total plasma DNA much more than DNA from necrotic cells and its increase predicted future development of multiple-organ failure and death."@en . "Pachl, Jan" . . . . "0862-8408" . "multiple-organ failure; early apoptosis; apoptic DNA; plasma free DNA"@en . "3"^^ . . "6"^^ . "Apoptosis as an early event in the development of multiple organ failure?" . . . . . "RIV/00216208:11120/05:00001004" . "Apoptosis as an early event in the development of multiple organ failure?" . . "Apopt\u00F3za jako \u010Dasn\u00E1 ud\u00E1lost p\u0159i rozvoji multiorg\u00E1nov\u00E9ho selh\u00E1v\u00E1n\u00ED?"@cs . . . "Apopt\u00F3za jako \u010Dasn\u00E1 ud\u00E1lost p\u0159i rozvoji multiorg\u00E1nov\u00E9ho selh\u00E1v\u00E1n\u00ED?"@cs . "3"^^ .