. "[CCB791EBFA50]" . . "iosimenol; nonionic dimer; pharmacokinetics; viscosity; toxicology; x-ray contrast media"@en . . "Investigative Radiology" . "11"^^ . "11"^^ . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "0020-9996" . "Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics" . . "1"^^ . . "http://dx.doi.org/10.1097/01.rli.0000115332.25954.a3" . "10.1097/01.rli.0000115332.25954.a3" . . . "Newer radiologic techniques require fast bolus injections and thus low-viscosity, high-concentration, well-tolerated contrast media (CM), especially in vulnerable patients. To this end, we designed and developed iosimenol, a novel isotonic nonionic dimer, and have conducted tests to enable its clinical evaluation. Standard physicochemical methods were used. Effects on erythrocyte morphology and coagulation were investigated in human and rat blood. Neural tolerance was assessed by behavioral tests in rats after intracisternal injection. Immunosensitizing potential was evaluated by the skin sensitization test in guinea pigs and by the popliteal lymph node assay in rats. Pharmacokinetics and biotransformation were investigated in rats and dogs. Iosimenol is extremely hydrophilic, it is less viscous than any other isotonic CM, has little effect on erythrocytes and blood coagulation, and has good neural tolerance. No immunosensitizing effect was found in validated animal models. Pharmacokinetics are identi" . "RIV/00216208:11120/04:00003835!RIV12-MSM-11120___" . "568982" . . "Newer radiologic techniques require fast bolus injections and thus low-viscosity, high-concentration, well-tolerated contrast media (CM), especially in vulnerable patients. To this end, we designed and developed iosimenol, a novel isotonic nonionic dimer, and have conducted tests to enable its clinical evaluation. Standard physicochemical methods were used. Effects on erythrocyte morphology and coagulation were investigated in human and rat blood. Neural tolerance was assessed by behavioral tests in rats after intracisternal injection. Immunosensitizing potential was evaluated by the skin sensitization test in guinea pigs and by the popliteal lymph node assay in rats. Pharmacokinetics and biotransformation were investigated in rats and dogs. Iosimenol is extremely hydrophilic, it is less viscous than any other isotonic CM, has little effect on erythrocytes and blood coagulation, and has good neural tolerance. No immunosensitizing effect was found in validated animal models. Pharmacokinetics are identi"@en . "Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics" . . . . "Sovak, M." . "RIV/00216208:11120/04:00003835" . "000189320200006" . . . "Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics"@en . "Fi\u0161erov\u00E1, Magdal\u00E9na" . "Iosimenol, a low-viscosity nonionic dimer - Preclinical physicochemistry, pharmacology, and pharmacokinetics"@en . . "3" . . "N" . . "11120" . "39" .