"P(LN00B122), P(NF6031), P(NF7626), Z(AV0Z5011922)" . "RIV/00216208:11120/04:00001268!RIV/2005/MSM/111205/N" . "Kaiser, Miroslav" . . . "32;41" . "[BCCDF458F24E]" . . . "Suppl. 3" . "RIV/00216208:11120/04:00001268" . "\u0160\u0165astn\u00FD, Franti\u0161ek" . . . . . "Interactions; Dopamine; D1/D2; Receptor; Glutamate; Receptor; Molecules; Animal; Models; Schizophrenia"@en . . . . . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . . . "Schizofrenie p\u0159edstavuje skupinu klinick\u00FDch projev\u016F maj\u00EDc\u00EDch v\u00FDznamnou d\u011Bdi\u010Dnou slo\u017Eku. Vztahy mezi jednotliv\u00FDmi genov\u00FDmi loci a rizikem vzniku schizofrenie je v\u0161ak v sou\u010Dasnosti nesnadn\u00E9 stanovit. Je to d\u016Fsledek skute\u010Dnosti, \u017Ee diagn\u00F3za schizofrenie je zalo\u017Eena na klinick\u00E9 manifestaci rozv\u00EDjej\u00EDc\u00EDch se funk\u010Dn\u00EDch projev\u016F, kter\u00E9 nelze jednoduch\u00FDm zp\u016Fsobem p\u0159i\u0159adit jednotliv\u00FDm gen\u016Fm. Nicm\u00E9n\u011B, molekul\u00E1rn\u00ED \u00FAseky ur\u010Dit\u00FDch receptor\u016F (dopaminov\u00FD D1/D2 receptor a glutam\u00E1tov\u00FD receptor NMDA typu) se v\u00FDznamn\u011B pod\u00EDlej\u00ED na etiopatofyziologii t\u00E9to poruchy. M\u016F\u017Ee to b\u00FDt d\u016Fsledek jejich principi\u00E1ln\u00ED \u00FA\u010Dasti ve v\u011Bt\u0161in\u011B z\u00E1kladn\u00EDch funk\u010Dn\u00EDch aktivit CNS, v jejich strategick\u00E9 distribuci v t\u011Bch oblastech mozku, kter\u00E9 souvisej\u00ED se schizofreni\u00ED a sou\u010Dasn\u011B jsou mimo\u0159\u00E1dn\u011B citliv\u00E9 na vlivy prost\u0159ed\u00ED. Mnoh\u00E9 skute\u010Dnosti t\u00FDkaj\u00EDc\u00ED se patofyziologie schizofrenie n\u00E1m mohou pomoci odhalit anim\u00E1ln\u00ED modely t\u00E9to du\u0161evn\u00ED poruchy."@cs . "Skuba, Iryna" . "8" . . "1211-7579" . "Skuba, Iryna" . "Buben\u00EDkov\u00E1, V\u011Bra" . "11"^^ . . "Interactions of Dopamine D1/D2 Receptor with Glutamate Receptor of NMDA type: from Molecules to Animal Models of Schizophrenia"@en . "Schizophrenia is a group of syndroms with a strong hereditary component. However, the links betwen varations in particular genetic loci and the risk of developing schizophrenia are inherently difficult to establish. This is because the diagnosis of schizophrenia is based on the manifestation of emergent functional traits that cannot be, by their nature, linked in a simple fashion to single genes. Yet, molecular components of certain receptors (dopamine D1 and D2 as well as glutamate receptor of NMDA type) seem to be significantly involved in the ethiology of the disorder. This may be a result of their prominent involvement in the most fundamental mechanisms of neural function, strategic distribution in brain regions most related to schizophrenia and particular susceptibility to environmental influences. Such aspects concerning the pathophysiology of schizophrenia can be conveniently studied in animal models of this psychiatriic disorder."@en . "Interakce dopaminov\u00E9ho D1/D2 receptoru s glutam\u00E1tov\u00FDm receptorem NMDA typu: od molekul k anim\u00E1ln\u00EDm model\u016Fm schizofrenie" . . . "Psychiatrie" . . . "6"^^ . "Schizofrenie p\u0159edstavuje skupinu klinick\u00FDch projev\u016F maj\u00EDc\u00EDch v\u00FDznamnou d\u011Bdi\u010Dnou slo\u017Eku. Vztahy mezi jednotliv\u00FDmi genov\u00FDmi loci a rizikem vzniku schizofrenie je v\u0161ak v sou\u010Dasnosti nesnadn\u00E9 stanovit. Je to d\u016Fsledek skute\u010Dnosti, \u017Ee diagn\u00F3za schizofrenie je zalo\u017Eena na klinick\u00E9 manifestaci rozv\u00EDjej\u00EDc\u00EDch se funk\u010Dn\u00EDch projev\u016F, kter\u00E9 nelze jednoduch\u00FDm zp\u016Fsobem p\u0159i\u0159adit jednotliv\u00FDm gen\u016Fm. Nicm\u00E9n\u011B, molekul\u00E1rn\u00ED \u00FAseky ur\u010Dit\u00FDch receptor\u016F (dopaminov\u00FD D1/D2 receptor a glutam\u00E1tov\u00FD receptor NMDA typu) se v\u00FDznamn\u011B pod\u00EDlej\u00ED na etiopatofyziologii t\u00E9to poruchy. M\u016F\u017Ee to b\u00FDt d\u016Fsledek jejich principi\u00E1ln\u00ED \u00FA\u010Dasti ve v\u011Bt\u0161in\u011B z\u00E1kladn\u00EDch funk\u010Dn\u00EDch aktivit CNS, v jejich strategick\u00E9 distribuci v t\u011Bch oblastech mozku, kter\u00E9 souvisej\u00ED se schizofreni\u00ED a sou\u010Dasn\u011B jsou mimo\u0159\u00E1dn\u011B citliv\u00E9 na vlivy prost\u0159ed\u00ED. Mnoh\u00E9 skute\u010Dnosti t\u00FDkaj\u00EDc\u00ED se patofyziologie schizofrenie n\u00E1m mohou pomoci odhalit anim\u00E1ln\u00ED modely t\u00E9to du\u0161evn\u00ED poruchy." . "11120" . "H\u00F6schl, Cyril" . . . "568592" . "10"^^ . "Interakce dopaminov\u00E9ho D1/D2 receptoru s glutam\u00E1tov\u00FDm receptorem NMDA typu: od molekul k anim\u00E1ln\u00EDm model\u016Fm schizofrenie"@cs . . "Interakce dopaminov\u00E9ho D1/D2 receptoru s glutam\u00E1tov\u00FDm receptorem NMDA typu: od molekul k anim\u00E1ln\u00EDm model\u016Fm schizofrenie"@cs . . . . "CZ - \u010Cesk\u00E1 republika" . . . "Interactions of Dopamine D1/D2 Receptor with Glutamate Receptor of NMDA type: from Molecules to Animal Models of Schizophrenia"@en . . "Interakce dopaminov\u00E9ho D1/D2 receptoru s glutam\u00E1tov\u00FDm receptorem NMDA typu: od molekul k anim\u00E1ln\u00EDm model\u016Fm schizofrenie" .