"Boubel\u00EDk, Michael" . . "Yang, M." . . . "NL - Nizozemsko" . "Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma" . . "7"^^ . "Syngeneick\u00FD lymph-node-targeting model zelen\u00E9ho fluorescentn\u00EDho protein-expresuj\u00EDc\u00ED Lewis\u016Fv plicn\u00ED karcinom"@cs . "Hoffman, R. M." . . . "S" . "Kolo\u0161tov\u00E1, Katar\u00EDna" . . . . "11120" . "Bobek, Vladim\u00EDr" . "000229240600004" . "4"^^ . "21" . "Syngeneick\u00FD lymph-node-targeting model zelen\u00E9ho fluorescentn\u00EDho protein-expresuj\u00EDc\u00ED Lewis\u016Fv plicn\u00ED karcinom"@cs . "Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma"@en . "0262-0898" . "The Lewis lung tumor has been extensively studied in both syngeneic and allogeneic mouse models. However, its metastatic potential and mechanism are poorly understood. The aim of the present study was to develop a highly metastatic lymph-node targeting, imageable model of the Lewis lung carcinoma in a syngeneic host. We report here a syngeneic model of the Lewis lung carcinoma in which the carcinoma cells are labeled with green fluorescent protein (GFP). The tumor cells were transplanted in the dorsal side of the ear of C57-B16 mice in order to give the tumor cells access to the lymphatic system. This model of the Lewis lung carcinoma extensively metastasized to numerous lymph nodes throughout the body of the animal as well as visceral organs, as visualized by fluorescence microscopy using the bright GFP signal. Twenty-one different metastatic sites, including lymph nodes throughout the body, were identified among the cohort of transplanted animals. The data demonstrate a predilection of the Lewis lun"@en . . "[C7BB9E57CEA7]" . . "Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma" . "Jiang, P." . "Pint\u00E9rov\u00E1, Daniela" . . "Pr\u00E1ce popisuje syngeneick\u00FD lymph-node-targeting model zelen\u00E9ho fluorescentn\u00EDho protein-expresuj\u00EDc\u00ED Lewis\u016Fv plicn\u00ED karcinom"@cs . . "The Lewis lung tumor has been extensively studied in both syngeneic and allogeneic mouse models. However, its metastatic potential and mechanism are poorly understood. The aim of the present study was to develop a highly metastatic lymph-node targeting, imageable model of the Lewis lung carcinoma in a syngeneic host. We report here a syngeneic model of the Lewis lung carcinoma in which the carcinoma cells are labeled with green fluorescent protein (GFP). The tumor cells were transplanted in the dorsal side of the ear of C57-B16 mice in order to give the tumor cells access to the lymphatic system. This model of the Lewis lung carcinoma extensively metastasized to numerous lymph nodes throughout the body of the animal as well as visceral organs, as visualized by fluorescence microscopy using the bright GFP signal. Twenty-one different metastatic sites, including lymph nodes throughout the body, were identified among the cohort of transplanted animals. The data demonstrate a predilection of the Lewis lun" . . "4"^^ . "Clinical & Experimental Metastasis" . . "589279" . . . . . . "RIV/00216208:11120/04:00000954!RIV09-MSM-11120___" . "Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma"@en . . "8" . . "metastasis; growth; cells; mice; implantation; cancer; mouse; host"@en . "RIV/00216208:11120/04:00000954" .