"Embryolet\u00E1ln\u00ED a teratogenn\u00ED \u00FA\u010Dinky nov\u00E9 platinov\u00E9 slou\u010Deniny, komplexu cistplatiny s prokainem (DPR) byly hodnoceny v experiment\u00E1ln\u00EDm modelu CD-1 my\u0161\u00ED. V\u00FDrazn\u00E1 redukce v\u00E1hy b\u0159ez\u00EDch my\u0161\u00ED byla pozorov\u00E1na po aplikaci 21, resp. 28 mg/kg DPR. D\u00E1vkov\u011B z\u00E1visl\u00E1 redukce v\u00E1hy plod\u016F byla pozorov\u00E1na po aplikaci DPR v embryon\u00E1ln\u00EDch dnech 9,13 a 16. Komplex DPR vyvol\u00E1val i zevn\u00ED malformace plodu, pozorov\u00E1ny byly t\u0159i hepato-omfalok\u00E9ly a \u0161est roz\u0161t\u011Bpov\u00FDch defekt\u016F patra. Z anom\u00E1li\u00ED skeletu byly zaznamen\u00E1ny opo\u017Ed\u011Bn\u00E1 osifikace a tvorba nadbyte\u010Dn\u00FDch \u017Eeber. Z\u00EDskan\u00E9 v\u00FDsledky potvrdily embryotoxick\u00FD defekt DPR v p\u0159\u00EDpad\u011B jeho pod\u00E1n\u00ED v pr\u016Fb\u011Bhu organogeneze."@cs . . "Embryolet\u00E1ln\u00ED a teratogenn\u00ED \u00FA\u010Dinek nov\u00E9 platinov\u00E9 slou\u010Deniny DPR u b\u0159ez\u00EDch my\u0161\u00ED"@cs . . "Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice" . "Archives of Toxicology" . "11120" . "Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "7"^^ . . "Mandys, V\u00E1clav" . . "605822" . . . "7"^^ . . "Our data demonstrated that DPR can cause embryotoxic effects if administered during the period of organogenesis and early histogenesis. Beside embryo-lethality, DPR induced growth retardation and malformations in surviving fetuses." . "Our data demonstrated that DPR can cause embryotoxic effects if administered during the period of organogenesis and early histogenesis. Beside embryo-lethality, DPR induced growth retardation and malformations in surviving fetuses."@en . . "000186094100006" . "0340-5761" . "Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice"@en . "DPR; embyotoxicity; teratogenicity; mouse"@en . "Ognio, E." . "77" . "10" . . . "Embryolet\u00E1ln\u00ED a teratogenn\u00ED \u00FA\u010Dinek nov\u00E9 platinov\u00E9 slou\u010Deniny DPR u b\u0159ez\u00EDch my\u0161\u00ED"@cs . . "RIV/00216208:11120/03:00000531" . "1"^^ . . "[9DC7BAC9780B]" . "RIV/00216208:11120/03:00000531!RIV09-AV0-11120___" . . "Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice"@en . . . . "Z(AV0Z5039906)" .