"000180614700007" . "6" . "Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo" . . "11120" . "49" . "Peterka, Miroslav" . . "cisplatin; cisplatin procaine complex DPR; teratogen; malformation"@en . "Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo"@en . "6"^^ . . . . "644930" . "Neoplasma" . . "1"^^ . "V" . "SK - Slovensk\u00E1 republika" . . "Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo"@en . "[EC862746FA7B]" . "7"^^ . "0028-2685" . . . "Mandys, V\u00E1clav" . . "RIV/00216208:11120/02:00003696!RIV12-MSM-11120___" . "Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexed cisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart septum defects an"@en . "Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexed cisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart septum defects an" . . . . . "RIV/00216208:11120/02:00003696" . . "Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo" .