. "More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed. Longitudinal follow-up of biological characteristics (growth, survival, haematology) of both multiple cases of primary disease and s.c. passaged lymphomas as well as comparative immunophenotypic and karyotypic studies are concluded. In these T-cell lymphomas (mostly CD4 positive), arising on the same genetic background of the inbred SD strain, the aberrations involving chromosome 11 have been recognized as a typical non-random cytogenetic marker. This unique rat model of lymphoblastic lymphomas/leukaemias, relevant to human pathology, seems to be very suitable for testing different anticancer therapeutic strategies, as it is documented by results of a number of various protocols conducted in our laboratory."@en . "13"^^ . "RIV/00216208:11120/02:00003695!RIV12-MSM-11120___" . . "RIV/00216208:11120/02:00003695" . "1"^^ . "Otov\u00E1, B." . . "Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub)"@en . . "000180060500001" . "Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub)"@en . . "More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed. Longitudinal follow-up of biological characteristics (growth, survival, haematology) of both multiple cases of primary disease and s.c. passaged lymphomas as well as comparative immunophenotypic and karyotypic studies are concluded. In these T-cell lymphomas (mostly CD4 positive), arising on the same genetic background of the inbred SD strain, the aberrations involving chromosome 11 have been recognized as a typical non-random cytogenetic marker. This unique rat model of lymphoblastic lymphomas/leukaemias, relevant to human pathology, seems to be very suitable for testing different anticancer therapeutic strategies, as it is documented by results of a number of various protocols conducted in our laboratory." . . . "Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub)" . "6"^^ . . . "CZ - \u010Cesk\u00E1 republika" . . . "T-cell; lymphoma; leukaemia; rat model; immunophenotype; cytogenetics; cell cycle; immunochemistry; experimental therapy"@en . . . "0015-5500" . "11120" . "6" . "Folia Biologica" . . "Relevant animal model of human lymphoblastic leukaemia/lymphoma - Spontaneous T-cell lymphomas in an inbred sprague-dawley rat strain (SD/Cub)" . . "Mandys, V\u00E1clav" . "[B75583D6E966]" . "V, Z(AV0Z5039906), Z(MSM 111100004)" . . . . "48" . . "662042" . . . . .