"Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice" . "RIV/00216208:11120/02:00002993!RIV12-GA0-11120___" . "Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice" . . . . . . "Starec, Miroslav" . . . "10.1016/s0165-5728(02)00211-4" . "644175" . . "RIV/00216208:11120/02:00002993" . "0165-5728" . "000178329200006" . "http://dx.doi.org/10.1016/s0165-5728(02)00211-4" . "Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice"@en . "P(GA310/98/0347)" . "NL - Nizozemsko" . "Journal of Neuroimmunology" . . . "130" . "11"^^ . "1-2" . "11120" . "7"^^ . . "Fi\u0161erov\u00E1, Anna" . "The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms" . . . "1"^^ . "The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine (DA)) was investigated in restraint stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of the spleen morphology, TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. These findings demonstrate that D2-type dopaminergic mechanism represents the dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction and contribute to cell responses at postreceptor level of both, central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms"@en . . "Effect of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice"@en . "[D69ED90D69B0]" . "restraint stress; cytokine; NK cell"@en . .