"21" . . . . "cisplatin; procaine; antitumor activity"@en . "Mandys, V\u00E1clav" . "Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice"@en . "000167875900072" . "RIV/00216208:11120/01:00003667!RIV12-MSM-11120___" . "11120" . . "Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice"@en . . . "Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice" . . "0250-7005" . "Time-dependent influence of procaine hydrochloride on cisplatin antitumor activity in p388 tumor bearing mice" . . "GR - \u0158eck\u00E1 republika" . "Viale, M." . . . "3"^^ . . . "1"^^ . . "4"^^ . "In previous papers (1,2) we demonstrated that procaine hydrochloride may increase the therapeutic index of cisplatin by an improvement of its antitumor activity and a reduction of its nephrotoxicity. In the present study we investigated the relationship between the antitumor activity obtained by cisplatin associated with procaine hydrochloride and the relative time of administration of these two agents. When procaine hydrochloride (40 mg/Kg body wt) was administered 30 or 120 minutes before cisplatin (16 mg/kg) diluted in normal saline (i.e. clinical condition) it increased, although not significantly, its percent increase in life span (%ILS) and cure rate (%ILS: +292 and +217 vs +150; cute rate: 46.2% and 42.3% vs 23%, respectively), compared to cisplatin alone treatment. These results became statistically significant when procaine hydrochloride was given either simultaneously with cisplatin ol 30 and 120 minutes thereafter (%ILS: >400 vs +150; cure rate: 65.4% 73.1% and 68% vs 23%, respectively)."@en . "Anticancer Research" . "RIV/00216208:11120/01:00003667" . . . "698826" . "Z(AV0Z5039906), Z(MSM 111200001)" . . "1A" . "In previous papers (1,2) we demonstrated that procaine hydrochloride may increase the therapeutic index of cisplatin by an improvement of its antitumor activity and a reduction of its nephrotoxicity. In the present study we investigated the relationship between the antitumor activity obtained by cisplatin associated with procaine hydrochloride and the relative time of administration of these two agents. When procaine hydrochloride (40 mg/Kg body wt) was administered 30 or 120 minutes before cisplatin (16 mg/kg) diluted in normal saline (i.e. clinical condition) it increased, although not significantly, its percent increase in life span (%ILS) and cure rate (%ILS: +292 and +217 vs +150; cute rate: 46.2% and 42.3% vs 23%, respectively), compared to cisplatin alone treatment. These results became statistically significant when procaine hydrochloride was given either simultaneously with cisplatin ol 30 and 120 minutes thereafter (%ILS: >400 vs +150; cure rate: 65.4% 73.1% and 68% vs 23%, respectively)." . "[2E25026399A1]" .