"A 45-year-old woman had symmetrical livid plaques with yellowish hyperkeratoses for 5 years, which progressed on to the fingers and toes and on the soles of the feet. Two years later creamy, whitish areas and maceration appeared on the buccal mucosa and the lips. A skin biopsy revealed massive collagen hyaline degeneration in the perivascular area, hyperkeratosis and hypergranulosis, small lymphocyte infiltrates with several melanophages and extravasates of erythrocytes in the upper corium. in perivascular areas and hydropic degeneration of basal keratinocytes. The findings using direct immunofluorescence were compatible with lupus erythematosus (LE). Laboratory investigation showed a slight leucopenia and thrombopenia, a slightly elevated erythrocyte sedimentation rate, hypocomplementaernia C3 and C4, a high titre of rheumatoid factor and antinuclear antibodies positivity of extractable nuclear antigen. The results reflected probably the development of a systemic form of the disease. The patient was" . . "RIV/00216208:11120/01:00003666!RIV12-MSM-11120___" . "Verrucous form of chilblain lupus erythematosus" . "Verrucous form of chilblain lupus erythematosus"@en . "10.1046/j.1468-3083.2001.00346.x" . "Journal of the European Academy of Dermatology and Venereology" . "11120" . . "Pock, L." . "Verrucous form of chilblain lupus erythematosus" . . "Mandys, V\u00E1clav" . . . "5" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "5"^^ . . "000172032900018" . . . "4"^^ . "[A6705B071415]" . "15" . "1"^^ . "chilblain lupus; collagen hyalinization; verrucous form"@en . "Z(AV0Z5039906), Z(MSM 111200002)" . . "Verrucous form of chilblain lupus erythematosus"@en . "RIV/00216208:11120/01:00003666" . "A 45-year-old woman had symmetrical livid plaques with yellowish hyperkeratoses for 5 years, which progressed on to the fingers and toes and on the soles of the feet. Two years later creamy, whitish areas and maceration appeared on the buccal mucosa and the lips. A skin biopsy revealed massive collagen hyaline degeneration in the perivascular area, hyperkeratosis and hypergranulosis, small lymphocyte infiltrates with several melanophages and extravasates of erythrocytes in the upper corium. in perivascular areas and hydropic degeneration of basal keratinocytes. The findings using direct immunofluorescence were compatible with lupus erythematosus (LE). Laboratory investigation showed a slight leucopenia and thrombopenia, a slightly elevated erythrocyte sedimentation rate, hypocomplementaernia C3 and C4, a high titre of rheumatoid factor and antinuclear antibodies positivity of extractable nuclear antigen. The results reflected probably the development of a systemic form of the disease. The patient was"@en . "0926-9959" . "700228" . "http://dx.doi.org/10.1046/j.1468-3083.2001.00346.x" . . . . .