"Nonapetid oxytocin (OT) is a hormone with peripheral and central effects. OT operates through one type of oxytocin receptor (OTR) of a G-regulatory proteins. Current research aims to uncover mechanisms of action of OT on the molecular and cellular level to the therapeutic use of this knowledge. The key issue is the knowledge of the location and density of OTR in individual organs and tissues. OTR presence of a protein is determined by immunohistochemical methods using specific primary antibodies. This method is very demanding, not only technically, but also economically. For this reason, we sought an alternative option to visualize the oxytocin receptor. The invention relates to newly developed synthesis of fluorescent derivatives of oxytocin, which are intended for visualization of oxytocin receptors in mammalian tissues with OT labeled with a fluorescent marker, without using the primary antibodies. The invention is the preparation of chimeras, derivatives of OT conjugated green emitting fluorescent dye {2- [phenyl (2H-pyrrol-2-ylidene-\u03BAN) methyl] -1H-\u03BAN pyrrolato} bor (Bodipy) using 1,3-dipolar cycloaddition."@en . "5"^^ . "Jur\u00E1\u0161ek, Michal" . . . . "2014-11-20+01:00"^^ . . "27516" . . . . . . . "[18596604A6C0]" . . . "Nonapetid oxytocin (OT) je hormon s perifern\u00EDmi i centr\u00E1ln\u00EDmi \u00FA\u010Dinky. OT p\u016Fsob\u00ED prost\u0159ednictv\u00EDm jednoho typu oxytocinov\u00E9ho receptoru (OTR) sp\u0159a\u017Een\u00E9ho s G-regula\u010Dn\u00EDmi proteiny. Sou\u010Dasn\u00FD v\u00FDzkum sm\u011B\u0159uje k odhalen\u00ED mechanism\u016F p\u016Fsoben\u00ED OT na molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 \u00FArovni s c\u00EDlem terapeutick\u00E9ho vyu\u017Eit\u00ED t\u011Bchto poznatk\u016F. Kl\u00ED\u010Dov\u00FDm probl\u00E9mem je znalost lokalizace a denzity OTR v jednotliv\u00FDch org\u00E1nech a tk\u00E1n\u00EDch. P\u0159\u00EDtomnost proteinu OTR se ur\u010Duje pomoc\u00ED imunohistochemick\u00FDch metod s vyu\u017Eit\u00EDm specifick\u00FDch prim\u00E1rn\u00EDch protil\u00E1tek. Tato metoda je v\u0161ak velni n\u00E1ro\u010Dn\u00E1 nejen technicky, ale i ekonomicky. Z tohoto d\u016Fvodu jsme hledali alternativn\u00ED mo\u017Enost vizualizovat oxytocinov\u00FD receptor. Vyn\u00E1lez se t\u00FDk\u00E1 nov\u011B vyvinut\u00E9 synt\u00E9zy fluorescen\u010Dn\u00EDch deriv\u00E1t\u016F oxytocinu, kter\u00E9 jsou ur\u010Deny k vizualizaci OTR ve tk\u00E1n\u00EDch savc\u016F. s oxytocinem ozna\u010Den\u00FDm fluorescen\u010Dn\u00EDm markerem, bez nutnosti pou\u017Eit\u00ED prim\u00E1rn\u00EDch protil\u00E1tek. Podstatou vyn\u00E1lezu je p\u0159\u00EDprava chim\u00E9r, deriv\u00E1t\u016F oxytocinu konjugovan\u00FDch zelen\u011B emituj\u00EDc\u00EDm fluorescen\u010Dn\u00EDm barvivem {2-[phenyl(2H-pyrrol-2-yliden-\u03BAN)methyl]-1H-pyrrolato-\u03BAN}bor (Bodipy) s vyu\u017Eit\u00EDm 1,3-dipol\u00E1rn\u00ED cykloadice." . "http://isdv.upv.cz/portal/pls/portal/portlets.pts.det?xprim=10055186&lan=cs&s_majs=&s_puvo=&s_naze=Analogy%20oxytocinu%20pro%20vizualizaci%20oxytocinov%C3%BDch%20receptor%C5%AF&s_anot=" . "Oxytocin analogs for visualization of oxyticin receptors"@en . . "Dra\u0161ar, Pavel" . . . . . "Nonapetid oxytocin (OT) je hormon s perifern\u00EDmi i centr\u00E1ln\u00EDmi \u00FA\u010Dinky. OT p\u016Fsob\u00ED prost\u0159ednictv\u00EDm jednoho typu oxytocinov\u00E9ho receptoru (OTR) sp\u0159a\u017Een\u00E9ho s G-regula\u010Dn\u00EDmi proteiny. Sou\u010Dasn\u00FD v\u00FDzkum sm\u011B\u0159uje k odhalen\u00ED mechanism\u016F p\u016Fsoben\u00ED OT na molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 \u00FArovni s c\u00EDlem terapeutick\u00E9ho vyu\u017Eit\u00ED t\u011Bchto poznatk\u016F. Kl\u00ED\u010Dov\u00FDm probl\u00E9mem je znalost lokalizace a denzity OTR v jednotliv\u00FDch org\u00E1nech a tk\u00E1n\u00EDch. P\u0159\u00EDtomnost proteinu OTR se ur\u010Duje pomoc\u00ED imunohistochemick\u00FDch metod s vyu\u017Eit\u00EDm specifick\u00FDch prim\u00E1rn\u00EDch protil\u00E1tek. Tato metoda je v\u0161ak velni n\u00E1ro\u010Dn\u00E1 nejen technicky, ale i ekonomicky. Z tohoto d\u016Fvodu jsme hledali alternativn\u00ED mo\u017Enost vizualizovat oxytocinov\u00FD receptor. Vyn\u00E1lez se t\u00FDk\u00E1 nov\u011B vyvinut\u00E9 synt\u00E9zy fluorescen\u010Dn\u00EDch deriv\u00E1t\u016F oxytocinu, kter\u00E9 jsou ur\u010Deny k vizualizaci OTR ve tk\u00E1n\u00EDch savc\u016F. s oxytocinem ozna\u010Den\u00FDm fluorescen\u010Dn\u00EDm markerem, bez nutnosti pou\u017Eit\u00ED prim\u00E1rn\u00EDch protil\u00E1tek. Podstatou vyn\u00E1lezu je p\u0159\u00EDprava chim\u00E9r, deriv\u00E1t\u016F oxytocinu konjugovan\u00FDch zelen\u011B emituj\u00EDc\u00EDm fluorescen\u010Dn\u00EDm barvivem {2-[phenyl(2H-pyrrol-2-yliden-\u03BAN)methyl]-1H-pyrrolato-\u03BAN}bor (Bodipy) s vyu\u017Eit\u00EDm 1,3-dipol\u00E1rn\u00ED cykloadice."@cs . . "Analogy oxytocinu pro vizualizaci oxytocinov\u00FDch receptor\u016F"@cs . . . "11110" . "Hynie, Sixtus" . "Prague" . . "RIV/00216208:11110/14:10286677" . . . . . "Klenerov\u00E1, V\u011Bra" . . . "\u00DA\u0159ad pr\u016Fmyslov\u00E9ho vlastnictv\u00ED" . "Analogy oxytocinu pro vizualizaci oxytocinov\u00FDch receptor\u016F"@cs . "Flegel, Martin" . "Oxytocin analogs for visualization of oxyticin receptors"@en . "Analogy oxytocinu pro vizualizaci oxytocinov\u00FDch receptor\u016F" . "Flegelov\u00E1, Zuzana" . "7"^^ . "\u0160kopek, Petr" . "I" . "Analogy oxytocinu pro vizualizaci oxytocinov\u00FDch receptor\u016F" . "RIV/00216208:11110/14:10286677!RIV15-MSM-11110___" . "Bodipy; fluorescent marker; chimeras; visualization of oxytocin receptor; oxytocin receptor; Oxytocin"@en . "2573" .