"Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases"@en . "Ursu, S." . "18146" . "14" . "http://dx.doi.org/10.1038/tpj.2014.3" . . "S" . "Bohm, M." . . . "Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases"@en . "Cobb, J." . . "RIV/00216208:11110/14:10286356!RIV15-MSM-11110___" . . . "11110" . "cases; arthritis; idiopathic; juvenile; cohort; large; response; methotrexate; for; genes; novel; reveal; data; Genome-wide"@en . "000340216000008" . "21"^^ . "van Zeist, B." . "Flynn, E." . "Moncrieffe, H." . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "14"^^ . "Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P<0.001). Phase II analysis increased SNP density in the most strongly associated regions, identifying 14 regions (P < 1 x 10(-5)): three contain genes of particular biological interest (ZMIZ1, TGIF1 and CFTR). These data suggest a role for novel pathways in MTX response and further investigations within associated regions will help to reach our goal of predicting response to MTX in JIA." . "Pharmacogenomics Journal" . "Kassoumeri, L." . . . . . . . "de Jonge, R." . "1470-269X" . . "Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases" . "10.1038/tpj.2014.3" . . . . "Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P<0.001). Phase II analysis increased SNP density in the most strongly associated regions, identifying 14 regions (P < 1 x 10(-5)): three contain genes of particular biological interest (ZMIZ1, TGIF1 and CFTR). These data suggest a role for novel pathways in MTX response and further investigations within associated regions will help to reach our goal of predicting response to MTX in JIA."@en . "Wulffraat, N." . "Hinks, A." . "Patrick, F." . . . "Dole\u017Ealov\u00E1, Pavla" . "Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases" . "[3DB29D255AFE]" . "1"^^ . "Bulatovi\u010D, M." . . "Cule, E." . . "RIV/00216208:11110/14:10286356" . . "4" . .