"V" . "Ultradi\u00E1nn\u00ED rytmus glukokortikoid\u016F: nov\u00E9 diagnostick\u00E9 a l\u00E9\u010Debn\u00E9 mo\u017Enosti poruch osy hypotalamus - hypof\u00FDza - nadledviny?" . "2"^^ . "RIV/00216208:11110/14:10285928" . . "Glukokortikoidy uvoln\u011Bn\u00E9 do cirkulace kol\u00EDsaj\u00ED podle cirkadi\u00E1nn\u00EDho rytmu. Odb\u011Bry krve v pr\u016Fb\u011Bhu 24 hodin v 10minutov\u00FDch intervalech odhalily, \u017Ee z\u00E1kladem cirkadi\u00E1nn\u00EDho rytmu je epizodick\u00E1 pulzace glukokortikoid\u016F s t\u00E9m\u011B\u0159 hodinovou frekvenc\u00ED - ultradi\u00E1nn\u00ED rytmus. V posledn\u00ED dob\u011B se intenzivn\u011B studuje jeho v\u00FDznam. Ukazuje se, \u017Ee je kl\u00ED\u010Dov\u00FD pro spr\u00E1vnou regulaci exprese gen\u016F a t\u00EDm udr\u017Een\u00ED homeost\u00E1zy organismu. Zm\u011Bny ultradi\u00E1nn\u00EDho rytmu mohou b\u00FDt p\u0159\u00ED\u010Dinou \u0159ady metabolick\u00FDch i psychiatrick\u00FDch onemocn\u011Bn\u00ED. Naopak nefyziologick\u00E1 l\u00E9\u010Dba glukokortikoidy nezohled\u0148uj\u00EDc\u00ED ultradi\u00E1nn\u00ED rytmus, vedouc\u00ED k dlouhodob\u00E9 expozici tk\u00E1n\u00ED zv\u00FD\u0161en\u00FDm koncentrac\u00EDm glukokortikoid\u016F, se zd\u00E1 b\u00FDt p\u0159\u00ED\u010Dinou ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F l\u00E9\u010Dby glukokortikoidy. I p\u0159es snahy o napodoben\u00ED alespo\u0148 \u010D\u00E1sti cirkadi\u00E1nn\u00EDho rytmu glukokortikoid\u016F modern\u00EDmi l\u00E9ky je st\u00E1le mortalita pacient\u016F s nedostate\u010Dnost\u00ED k\u016Fry nadledvin vysok\u00E1." . . "Diabetologie, metabolismus, endokrinologie, vyziva." . . "Kr\u0161ek, Michal" . "Ultradi\u00E1nn\u00ED rytmus glukokortikoid\u016F: nov\u00E9 diagnostick\u00E9 a l\u00E9\u010Debn\u00E9 mo\u017Enosti poruch osy hypotalamus - hypof\u00FDza - nadledviny?"@cs . "CZ - \u010Cesk\u00E1 republika" . "\u0160im\u016Fnkov\u00E1, Kate\u0159ina" . "Glukokortikoidy uvoln\u011Bn\u00E9 do cirkulace kol\u00EDsaj\u00ED podle cirkadi\u00E1nn\u00EDho rytmu. Odb\u011Bry krve v pr\u016Fb\u011Bhu 24 hodin v 10minutov\u00FDch intervalech odhalily, \u017Ee z\u00E1kladem cirkadi\u00E1nn\u00EDho rytmu je epizodick\u00E1 pulzace glukokortikoid\u016F s t\u00E9m\u011B\u0159 hodinovou frekvenc\u00ED - ultradi\u00E1nn\u00ED rytmus. V posledn\u00ED dob\u011B se intenzivn\u011B studuje jeho v\u00FDznam. Ukazuje se, \u017Ee je kl\u00ED\u010Dov\u00FD pro spr\u00E1vnou regulaci exprese gen\u016F a t\u00EDm udr\u017Een\u00ED homeost\u00E1zy organismu. Zm\u011Bny ultradi\u00E1nn\u00EDho rytmu mohou b\u00FDt p\u0159\u00ED\u010Dinou \u0159ady metabolick\u00FDch i psychiatrick\u00FDch onemocn\u011Bn\u00ED. Naopak nefyziologick\u00E1 l\u00E9\u010Dba glukokortikoidy nezohled\u0148uj\u00EDc\u00ED ultradi\u00E1nn\u00ED rytmus, vedouc\u00ED k dlouhodob\u00E9 expozici tk\u00E1n\u00ED zv\u00FD\u0161en\u00FDm koncentrac\u00EDm glukokortikoid\u016F, se zd\u00E1 b\u00FDt p\u0159\u00ED\u010Dinou ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F l\u00E9\u010Dby glukokortikoidy. I p\u0159es snahy o napodoben\u00ED alespo\u0148 \u010D\u00E1sti cirkadi\u00E1nn\u00EDho rytmu glukokortikoid\u016F modern\u00EDmi l\u00E9ky je st\u00E1le mortalita pacient\u016F s nedostate\u010Dnost\u00ED k\u016Fry nadledvin vysok\u00E1."@cs . "11110" . "Ultradi\u00E1nn\u00ED rytmus glukokortikoid\u016F: nov\u00E9 diagnostick\u00E9 a l\u00E9\u010Debn\u00E9 mo\u017Enosti poruch osy hypotalamus - hypof\u00FDza - nadledviny?" . . . "pump replacement treatment; glucocorticoids; circadian rhythm; Ultradian rhythm"@en . "http://www.tigis.cz/images/stories/DMEV/2014/02/06_simunkova_dmev_2-14.pdf" . . . "2" . . . . "17" . "51779" . "Ultradian rhythm of glucocorticoids: new diagnostic and treatment strategy of hypothalamic - pituitary - adrenal axis disorders?"@en . . . . "9"^^ . . "[3AA3A89321C0]" . "RIV/00216208:11110/14:10285928!RIV15-MSM-11110___" . . "Ultradian rhythm of glucocorticoids: new diagnostic and treatment strategy of hypothalamic - pituitary - adrenal axis disorders?"@en . "Ultradi\u00E1nn\u00ED rytmus glukokortikoid\u016F: nov\u00E9 diagnostick\u00E9 a l\u00E9\u010Debn\u00E9 mo\u017Enosti poruch osy hypotalamus - hypof\u00FDza - nadledviny?"@cs . "Glucocorticoids are released into the circulation under circadian fashion. Blood collection every 10 minutes over 24 hours revealed that circadian rhythm is actually made up from underlying ultradian pattern of glucocorticoids with frequency of about one pulse per hour. Recently, the research focused on ultradian rhythm significantly increased and showed its crucial relevance for gene regulation at tissue level and maintenance of homeostasis. Abnormal ultradian rhythm might contribute to prime out metabolic and psychiatric diseases and unphysiological continual replacement therapy appears to cause unwanted side effects of treatment. Despite numerous attempts of circadian rhythm replacement by advanced medication the mortality of patients with adrenal insufficiency remains still high."@en . . "2"^^ . "1211-9326" .