"http://www.prolekare.cz/ceska-gynekologie-clanek/selektivni-modulatory-progesteronoveho-receptoru-a-jejich-terapeuticke-vyuziti-40542" . "2"^^ . . . "\u0160vandov\u00E1, Ivana" . "RIV/00216208:11110/13:10138834!RIV14-MSM-11110___" . "7"^^ . "emergency contraception; termination of pregnancy; agonists and antagonists of the progesterone; selective progesterone receptor modulators; progesterone receptor; progesterone"@en . . "Dri\u00E1k, Daniel" . . . . "2" . . "1210-7832" . "104536" . . . . . "[0A7B1902AAC7]" . "I" . "V sou\u010Dasnosti vyvinut\u00E9 selektivn\u00ED modul\u00E1tory progesteronov\u00E9ho receptoru (SPRM) jsou steroidn\u00ED slou\u010Deniny s velk\u00FDm substituentem na uhl\u00EDku 11. Interaguj\u00ED s progesteronov\u00FDm receptorem a vykazuj\u00ED antagonistick\u00E9 nebo/a agonistick\u00E9 \u00FA\u010Dinky. Mifepriston byl schv\u00E1len k ukon\u010Den\u00ED gravidity a ulipristalacet\u00E1t jako pohotovostn\u00ED kontracepce a farmakologick\u00E1 l\u00E9\u010Dba d\u011Blo\u017En\u00EDch myom\u016F. SPRM inhibuj\u00ED proliferaci endometria a r\u016Fst myom\u016F a p\u0159edpokl\u00E1d\u00E1 se l\u00E9\u010Debn\u00FD efekt v p\u0159\u00EDpadech endometri\u00F3zy a jin\u00FDch estrogen-dependentn\u00EDch chorob." . "Selektivn\u00ED modul\u00E1tory progesteronov\u00E9ho receptoru a jejich terapeutick\u00E9 vyu\u017Eit\u00ED" . "Selektivn\u00ED modul\u00E1tory progesteronov\u00E9ho receptoru a jejich terapeutick\u00E9 vyu\u017Eit\u00ED" . "RIV/00216208:11110/13:10138834" . "\u010Cesk\u00E1 gynekologie" . "2013" . "V sou\u010Dasnosti vyvinut\u00E9 selektivn\u00ED modul\u00E1tory progesteronov\u00E9ho receptoru (SPRM) jsou steroidn\u00ED slou\u010Deniny s velk\u00FDm substituentem na uhl\u00EDku 11. Interaguj\u00ED s progesteronov\u00FDm receptorem a vykazuj\u00ED antagonistick\u00E9 nebo/a agonistick\u00E9 \u00FA\u010Dinky. Mifepriston byl schv\u00E1len k ukon\u010Den\u00ED gravidity a ulipristalacet\u00E1t jako pohotovostn\u00ED kontracepce a farmakologick\u00E1 l\u00E9\u010Dba d\u011Blo\u017En\u00EDch myom\u016F. SPRM inhibuj\u00ED proliferaci endometria a r\u016Fst myom\u016F a p\u0159edpokl\u00E1d\u00E1 se l\u00E9\u010Debn\u00FD efekt v p\u0159\u00EDpadech endometri\u00F3zy a jin\u00FDch estrogen-dependentn\u00EDch chorob."@cs . "11110" . . "Selektivn\u00ED modul\u00E1tory progesteronov\u00E9ho receptoru a jejich terapeutick\u00E9 vyu\u017Eit\u00ED"@cs . "Selektivn\u00ED modul\u00E1tory progesteronov\u00E9ho receptoru a jejich terapeutick\u00E9 vyu\u017Eit\u00ED"@cs . "CZ - \u010Cesk\u00E1 republika" . "3"^^ . . . "Sehnal, Borek" . . . . . . "Selective progesterone receptor modulators and their therapeutical use"@en . "Currently developed selective progesterone receptor modulators (SPRMs) are steroid derived compounds with a bulky radical substitution at carbon 11. They interact with progesterone receptor and exert antagonistic or/and agonistic effects. Mifepristone was approved for pregnancy termination and ulipristal acetate as emergency contraception and pharmacological therapy of uterine fibroids. SPRMs inhibit endometrial proliferation and myoma growth, this suggests a therapeutical effect in cases of endometriosis and other estrogen-dependent diseases."@en . "Selective progesterone receptor modulators and their therapeutical use"@en .