"SWI/SNF; MITF; melanoma; Brg1; Brm; INI1"@en . "[FE6E7FE5A5CE]" . . . . . "MITF meets chromatin in melanoma" . "New Developments in Chromatin Research" . . "Vachtenheim, Ji\u0159\u00ED" . "978-1-62081-816-9" . "New York" . . "MITF meets chromatin in melanoma"@en . . . . . "SWI/SNF chromatin remodeling complexes contain either Brm (Brahma) or Brg1 (Brahma-related gene 1) as the ATPase subunits. MITF (microphthalmia-associated transcription factor) is a pivotal protein required for the survival and proliferation of normal melanocytes and melanoma cells. MITF activates transcription of many genes regulating proliferation, apoptosis and invasiveness of melanoma cells and is a potential target for gene therapy of melanoma, an aggressive malignant tumor for which no effective therapy exists when metastases occur. Expression of MITF is absolutely dependent on this the SWI/SNF complex, and both Brg1- or Brm-containing complexes are sufficient to support MITF gene transcription. Additionally, especially Brg1 complex seems to support tumor growth even independently of the MITF axis. Thus, SWI/SNF complexes appear to be crucial determinants of melanoma development and progression." . . "2"^^ . . . "https://www.novapublishers.com/catalog/product_info.php?products_id=37164" . "SWI/SNF chromatin remodeling complexes contain either Brm (Brahma) or Brg1 (Brahma-related gene 1) as the ATPase subunits. MITF (microphthalmia-associated transcription factor) is a pivotal protein required for the survival and proliferation of normal melanocytes and melanoma cells. MITF activates transcription of many genes regulating proliferation, apoptosis and invasiveness of melanoma cells and is a potential target for gene therapy of melanoma, an aggressive malignant tumor for which no effective therapy exists when metastases occur. Expression of MITF is absolutely dependent on this the SWI/SNF complex, and both Brg1- or Brm-containing complexes are sufficient to support MITF gene transcription. Additionally, especially Brg1 complex seems to support tumor growth even independently of the MITF axis. Thus, SWI/SNF complexes appear to be crucial determinants of melanoma development and progression."@en . "RIV/00216208:11110/12:12847" . . "MITF meets chromatin in melanoma" . "247"^^ . "2"^^ . "11110" . . "18"^^ . "150734" . . "P(NT11229)" . . "MITF meets chromatin in melanoma"@en . "Nova Science Publishers" . "RIV/00216208:11110/12:12847!RIV13-MZ0-11110___" . . "Ondru\u0161ov\u00E1, \u013Dubica" . "Cell Biology Research Progress" . . .