. "1211-264X" . "biological therapy; infections; complications"@en . "11110" . "Review article about biological therapy and its infectious complications, which must be taken into the account, because the biologics interfere with many mechanisms of the host defense. Patients treated with biologics are prone to classical virulent infections (e.g., listeriosis, legionellosis and tuberculosis) and opportunistic infections such as progressive multifocal leukoencephalopathy. Furthermore, suppression of immune response that is caused by biologics may lead to reactivation of latent infections such as tuberculosis or viral hepatitis B. The knowledge of basic mechanisms, by which the biologics modify the immune response, is important for a rapid clinical diagnosis of possible etiology of infectious complication, its prevention and prophylaxis."@en . "Infek\u010Dn\u00ED komplikace biologick\u00E9 l\u00E9\u010Dby" . "Infectious complications of biological therapy"@en . . . . . . "CZ - \u010Cesk\u00E1 republika" . . "P\u0159ehledov\u00FD \u010Dl\u00E1nek o biologick\u00E9 terapii a jej\u00EDch infek\u010Dn\u00EDch komplikac\u00EDch, se kter\u00FDmi je nutn\u00E9, proto\u017Ee biologick\u00E1 terapie zasahuje do \u0159ady mechanizm\u016F obranyschopnosti. Pro pacienty na biologick\u00E9 l\u00E9\u010Db\u011B jsou rizikov\u00E9 klasick\u00E9 virulentn\u00ED infekce (nap\u0159. listeri\u00F3za, legionel\u00F3za a tuberkul\u00F3za) i infekce oportunn\u00ED, jako je progresivn\u00ED multifok\u00E1ln\u00ED leukoencefalopatie. Potla\u010Den\u00ED imunitn\u00ED odpov\u011Bdi p\u0159i l\u00E9\u010Db\u011B biologiky tak\u00E9 m\u016F\u017Ee v\u00E9st k reaktivaci latentn\u00ED tuberkul\u00F3zy nebo virov\u00E9 hepatitidy B. Znalost z\u00E1kladn\u00EDch mechanizm\u016F, kter\u00FDmi biologika ovliv\u0148uj\u00ED imunitn\u00ED odpov\u011B\u010F, je proto d\u016Fle\u017Eit\u00E1 odhad mo\u017En\u00E9 etiologie infek\u010Dn\u00ED komplikace i pro jej\u00ED p\u0159\u00EDpadnou prevenci a profylaxi." . . . "Klinick\u00E1 mikrobiologie a infek\u010Dn\u00ED l\u00E9ka\u0159stv\u00ED" . "3"^^ . "204283" . "3"^^ . . "Holub, Michal" . "P\u0159ehledov\u00FD \u010Dl\u00E1nek o biologick\u00E9 terapii a jej\u00EDch infek\u010Dn\u00EDch komplikac\u00EDch, se kter\u00FDmi je nutn\u00E9, proto\u017Ee biologick\u00E1 terapie zasahuje do \u0159ady mechanizm\u016F obranyschopnosti. Pro pacienty na biologick\u00E9 l\u00E9\u010Db\u011B jsou rizikov\u00E9 klasick\u00E9 virulentn\u00ED infekce (nap\u0159. listeri\u00F3za, legionel\u00F3za a tuberkul\u00F3za) i infekce oportunn\u00ED, jako je progresivn\u00ED multifok\u00E1ln\u00ED leukoencefalopatie. Potla\u010Den\u00ED imunitn\u00ED odpov\u011Bdi p\u0159i l\u00E9\u010Db\u011B biologiky tak\u00E9 m\u016F\u017Ee v\u00E9st k reaktivaci latentn\u00ED tuberkul\u00F3zy nebo virov\u00E9 hepatitidy B. Znalost z\u00E1kladn\u00EDch mechanizm\u016F, kter\u00FDmi biologika ovliv\u0148uj\u00ED imunitn\u00ED odpov\u011B\u010F, je proto d\u016Fle\u017Eit\u00E1 odhad mo\u017En\u00E9 etiologie infek\u010Dn\u00ED komplikace i pro jej\u00ED p\u0159\u00EDpadnou prevenci a profylaxi."@cs . "RIV/00216208:11110/11:8821" . "Infectious complications of biological therapy"@en . "Infek\u010Dn\u00ED komplikace biologick\u00E9 l\u00E9\u010Dby"@cs . "RIV/00216208:11110/11:8821!RIV12-MSM-11110___" . "Z(MSM0021620806)" . "Infek\u010Dn\u00ED komplikace biologick\u00E9 l\u00E9\u010Dby"@cs . . . "Rozsypal, Hanu\u0161" . "[C606FE1D2AFC]" . "Infek\u010Dn\u00ED komplikace biologick\u00E9 l\u00E9\u010Dby" . . "Chalupa, Pavel" . . . . . "17" . "6"^^ . . "1" .