"9"^^ . "2"^^ . "Mechanisms of G protein-coupled receptors regulation" . "32" . . "Within the last two decades of studies in the ever-expanding field of GPCR signaling, challenging insights were adopted. Growing evidence now asists the shift from classical linear model of signaling towards a considerably complex network of signaling pathways with many shared proteins and cross-talks. Considering the extensive and intriguing network of pathways activated by these receptors, it is apparent that multi-level system of regulation must exist to rigorously modulate the amplitude, duration and spatial aspects of the GPCR signaling. This review summarizes the principal mechanisms of GPCR regulation and gives the overview of recent advances in this field of research." . "RIV/00216208:11110/11:10852!RIV12-GA0-11110___" . "000300543900004" . . "Tom\u00E1nkov\u00E1, H." . "211295" . "1"^^ . "RIV/00216208:11110/11:10852" . . "Within the last two decades of studies in the ever-expanding field of GPCR signaling, challenging insights were adopted. Growing evidence now asists the shift from classical linear model of signaling towards a considerably complex network of signaling pathways with many shared proteins and cross-talks. Considering the extensive and intriguing network of pathways activated by these receptors, it is apparent that multi-level system of regulation must exist to rigorously modulate the amplitude, duration and spatial aspects of the GPCR signaling. This review summarizes the principal mechanisms of GPCR regulation and gives the overview of recent advances in this field of research."@en . "Neuroendocrinology Letters" . "0172-780X" . "P(GA309/09/0406)" . . "[1E09B0715833]" . . "5" . "http://node.nel.edu/?node_id=12266" . . . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . . "GPCR signaling; complex network; pathways"@en . . . . . "Mechanisms of G protein-coupled receptors regulation"@en . . "Mechanisms of G protein-coupled receptors regulation"@en . "11110" . "Myslive\u010Dek, Jarom\u00EDr" . . . . "Mechanisms of G protein-coupled receptors regulation" .