. "Zp\u016Fsob p\u011Bstov\u00E1n\u00ED lidsk\u00FDch mezenchymov\u00FDch kmenov\u00FDch bun\u011Bk, zejm\u00E9na pro l\u00E9\u010Dbu nehoj\u00EDc\u00EDch se fraktur, a bioreaktor k prov\u00E1d\u011Bn\u00ED tohoto zp\u016Fsobu"@cs . . "9"^^ . "Soukup, Tom\u00E1\u0161" . . "[B0131E17BF8A]" . . "Mulinkov\u00E1, Katar\u00EDna" . . "11110" . "Method of cultivation of human mesenchymal stem cells, particularly for the treatment of non-healing fractures, and bioreactor for carrying out this cultivation method"@en . "Ryp\u00E1\u010Dek, Franti\u0161ek" . . . "RIV/00216208:11110/09:5994" . "The present invention relates to a novel method of cultivation of mesenchymal stem cells, wherein after aseptic separation of mononuclear cells from the marrow blood, said cells are seeded in low density into sterile plastic cultivation vessels and cultivated for approximately one to three weeks in CellGroeTM Hematopoietic Stem Cell Medium, certified for the clinical use, with an addition of 10 percent of human serum and supplements, wherein the supplements are added at least once in the course of the cultivation, without removal of hematopoietic cells and without medium exchange during the cultivation procedure, without any interference in the closed cultivation system, under the standard conditions for the cultivation of tissue cultures."@en . "3"^^ . . "2009-10-08+02:00"^^ . "P(ND7448), Z(AV0Z40500505)" . . . "301148" . . "Zp\u016Fsob p\u011Bstov\u00E1n\u00ED lidsk\u00FDch mezenchymov\u00FDch kmenov\u00FDch bun\u011Bk, zejm\u00E9na pro l\u00E9\u010Dbu nehoj\u00EDc\u00EDch se fraktur, a bioreaktor k prov\u00E1d\u011Bn\u00ED tohoto zp\u016Fsobu" . . . "Prague" . . "Zp\u016Fsob p\u011Bstov\u00E1n\u00ED lidsk\u00FDch mezenchymov\u00FDch kmenov\u00FDch bun\u011Bk, zejm\u00E9na pro l\u00E9\u010Dbu nehoj\u00EDc\u00EDch se fraktur, a bioreaktor k prov\u00E1d\u011Bn\u00ED tohoto zp\u016Fsobu"@cs . . . "353549" . "Kobylka, Petr" . "http://isdv.upv.cz/portal/pls/portal/portlets.pts.det?xprim=962721&lan=cs" . . "Method of cultivation of human mesenchymal stem cells, particularly for the treatment of non-healing fractures, and bioreactor for carrying out this cultivation method"@en . . . . . "RIV/00216208:11110/09:5994!RIV12-MZ0-11110___" . "Hofman, Petr" . . "Tr\u010D, Tom\u00E1\u0161" . "Stehl\u00EDk, David" . "mesenchymal stem cells; cultivation; bone-fracture treatment"@en . "Podstata \u0159e\u0161en\u00ED spo\u010D\u00EDv\u00E1 ve zp\u016Fsobu p\u011Bstov\u00E1n\u00ED mezenchymov\u00FDch kmenov\u00FDch bun\u011Bk, ve kter\u00E9m po aseptick\u00E9m odd\u011Blen\u00ED mononukle\u00E1rn\u00EDch bun\u011Bk z d\u0159e\u0148ov\u00E9 krve jsou tyto nasazeny v n\u00EDzk\u00E9 hustot\u011B do steriln\u00EDch plastov\u00FDch kultiva\u010Dn\u00EDch n\u00E1dobek a p\u011Bstov\u00E1ny po dobu cca jednoho a\u017E t\u0159\u00ED t\u00FDdn\u016F v m\u00E9diu CellGro TM hematopoietic stem cell, schv\u00E1len\u00E9m pro klinick\u00E9 pou\u017Eit\u00ED s p\u0159\u00EDdavkem 10% lidsk\u00E9ho s\u00E9ra a suplement\u016F, p\u0159i\u010Dem\u017E v pr\u016Fb\u011Bhu kultivace jsou alespo\u0148 jednou p\u0159id\u00E1ny suplementy, ani\u017E je t\u0159eba odm\u00FDvat neadherentn\u00ED hemopoetick\u00E9 bu\u0148ky, ani\u017E je t\u0159eba m\u011Bnit \u017Eivn\u00FD roztok a ani\u017E je jakkoli t\u0159eba zasahovat do uzav\u0159en\u00E9ho kultiva\u010Dn\u00EDho syst\u00E9mu za b\u011B\u017En\u00FDch podm\u00EDnek pro p\u011Bstov\u00E1n\u00ED tk\u00E1\u0148ov\u00FDch kultur."@cs . "Klener, Pavel" . "Zp\u016Fsob p\u011Bstov\u00E1n\u00ED lidsk\u00FDch mezenchymov\u00FDch kmenov\u00FDch bun\u011Bk, zejm\u00E9na pro l\u00E9\u010Dbu nehoj\u00EDc\u00EDch se fraktur, a bioreaktor k prov\u00E1d\u011Bn\u00ED tohoto zp\u016Fsobu" . "\u00DA\u0159ad pr\u016Fmyslov\u00E9ho vlastnictv\u00ED" . "Univerzita Karlova v Praze/ \u00DAstav hematologie a krevn\u00ED transfuze/ \u00DAstav makromolekul\u00E1rn\u00ED chemie AV \u010CR" . . . "Podstata \u0159e\u0161en\u00ED spo\u010D\u00EDv\u00E1 ve zp\u016Fsobu p\u011Bstov\u00E1n\u00ED mezenchymov\u00FDch kmenov\u00FDch bun\u011Bk, ve kter\u00E9m po aseptick\u00E9m odd\u011Blen\u00ED mononukle\u00E1rn\u00EDch bun\u011Bk z d\u0159e\u0148ov\u00E9 krve jsou tyto nasazeny v n\u00EDzk\u00E9 hustot\u011B do steriln\u00EDch plastov\u00FDch kultiva\u010Dn\u00EDch n\u00E1dobek a p\u011Bstov\u00E1ny po dobu cca jednoho a\u017E t\u0159\u00ED t\u00FDdn\u016F v m\u00E9diu CellGro TM hematopoietic stem cell, schv\u00E1len\u00E9m pro klinick\u00E9 pou\u017Eit\u00ED s p\u0159\u00EDdavkem 10% lidsk\u00E9ho s\u00E9ra a suplement\u016F, p\u0159i\u010Dem\u017E v pr\u016Fb\u011Bhu kultivace jsou alespo\u0148 jednou p\u0159id\u00E1ny suplementy, ani\u017E je t\u0159eba odm\u00FDvat neadherentn\u00ED hemopoetick\u00E9 bu\u0148ky, ani\u017E je t\u0159eba m\u011Bnit \u017Eivn\u00FD roztok a ani\u017E je jakkoli t\u0159eba zasahovat do uzav\u0159en\u00E9ho kultiva\u010Dn\u00EDho syst\u00E9mu za b\u011B\u017En\u00FDch podm\u00EDnek pro p\u011Bstov\u00E1n\u00ED tk\u00E1\u0148ov\u00FDch kultur." . . "Pytl\u00EDk, Robert" .