"Plicn\u00ED hypertenze m\u016F\u017Ee komplikovat \u0159adu chorob, a tak m\u016F\u017Ee b\u00FDt zp\u016Fsobena mno\u017Estv\u00EDm mechanism\u016F od prost\u00E9 pasivn\u00ED elevace tlaku v plicnici a\u017E po z\u00E1va\u017En\u00E1 prim\u00E1rn\u00ED onemocn\u011Bn\u00ED plicn\u00EDch c\u00E9v. O zp\u016Fsobu farmakoterapie plicn\u00ED arteri\u00E1ln\u00ED hypertenze rozhoduje test akutn\u00ED plicn\u00ED vazodilatace. Pouze nemocn\u00ED s pozitivn\u00EDm testem jsou indikov\u00E1ni k l\u00E9\u010Db\u011B vysok\u00FDmi d\u00E1vkami blok\u00E1tor\u016F kalciov\u00FDch kan\u00E1l\u016F. V p\u0159\u00EDpad\u011B negativn\u00EDho testu je vedle chronick\u00E9 antikoagula\u010Dn\u00ED l\u00E9\u010Dby indikov\u00E1na tzv. specifick\u00E1 farmakoterapie (prostanoidy, antagonist\u00E9 endotelinov\u00FDch receptor\u016F, atd.) s \u00FA\u010Dinky nejen vazodilata\u010Dn\u00EDmi, ale rovn\u011B\u017E antiprolifera\u010Dn\u00EDmi a antiagrega\u010Dn\u00EDmi. P\u0159i vy\u010Derp\u00E1n\u00ED mo\u017Enost\u00ED farmakoterapie m\u016F\u017Ee p\u0159ich\u00E1zet v \u00FAvahu bal\u00F3nkov\u00E1 atri\u00E1ln\u00ED septostomie nebo transplantace plic. L\u00E9\u010Dbou volby u chronick\u00E9 tromboembolick\u00E9 plicn\u00ED hypertenze je endarterektomie plicnice u pacient\u016F s chirurgicky dosa\u017Eitelnou trombotickou obstrukc\u00ED." . . "Contemporary methods in the treatment of chronic pulmonary hypertension"@en . "2" . "Ambro\u017E, David" . "RIV/00216208:11110/09:4830!RIV10-MZ0-11110___" . "148" . "Aktu\u00E1ln\u00ED mo\u017Enosti l\u00E9\u010Dby chronick\u00E9 plicn\u00ED hypertenze"@cs . . "[E1F56A4D3024]" . . "Aktu\u00E1ln\u00ED mo\u017Enosti l\u00E9\u010Dby chronick\u00E9 plicn\u00ED hypertenze" . . "Mare\u0161ov\u00E1, Jana" . . "\u010Casopis l\u00E9ka\u0159\u016F \u010Desk\u00FDch" . "P(NR9224)" . "11110" . . "Pol\u00E1\u010Dek, Pavel" . "Contemporary methods in the treatment of chronic pulmonary hypertension"@en . . "302320" . . "Plicn\u00ED hypertenze m\u016F\u017Ee komplikovat \u0159adu chorob, a tak m\u016F\u017Ee b\u00FDt zp\u016Fsobena mno\u017Estv\u00EDm mechanism\u016F od prost\u00E9 pasivn\u00ED elevace tlaku v plicnici a\u017E po z\u00E1va\u017En\u00E1 prim\u00E1rn\u00ED onemocn\u011Bn\u00ED plicn\u00EDch c\u00E9v. O zp\u016Fsobu farmakoterapie plicn\u00ED arteri\u00E1ln\u00ED hypertenze rozhoduje test akutn\u00ED plicn\u00ED vazodilatace. Pouze nemocn\u00ED s pozitivn\u00EDm testem jsou indikov\u00E1ni k l\u00E9\u010Db\u011B vysok\u00FDmi d\u00E1vkami blok\u00E1tor\u016F kalciov\u00FDch kan\u00E1l\u016F. V p\u0159\u00EDpad\u011B negativn\u00EDho testu je vedle chronick\u00E9 antikoagula\u010Dn\u00ED l\u00E9\u010Dby indikov\u00E1na tzv. specifick\u00E1 farmakoterapie (prostanoidy, antagonist\u00E9 endotelinov\u00FDch receptor\u016F, atd.) s \u00FA\u010Dinky nejen vazodilata\u010Dn\u00EDmi, ale rovn\u011B\u017E antiprolifera\u010Dn\u00EDmi a antiagrega\u010Dn\u00EDmi. P\u0159i vy\u010Derp\u00E1n\u00ED mo\u017Enost\u00ED farmakoterapie m\u016F\u017Ee p\u0159ich\u00E1zet v \u00FAvahu bal\u00F3nkov\u00E1 atri\u00E1ln\u00ED septostomie nebo transplantace plic. L\u00E9\u010Dbou volby u chronick\u00E9 tromboembolick\u00E9 plicn\u00ED hypertenze je endarterektomie plicnice u pacient\u016F s chirurgicky dosa\u017Eitelnou trombotickou obstrukc\u00ED."@cs . "Aktu\u00E1ln\u00ED mo\u017Enosti l\u00E9\u010Dby chronick\u00E9 plicn\u00ED hypertenze" . "Lindner, Jaroslav" . . "Linhart, Ale\u0161" . "0008-7335" . "Aktu\u00E1ln\u00ED mo\u017Enosti l\u00E9\u010Dby chronick\u00E9 plicn\u00ED hypertenze"@cs . . "8"^^ . . . "7"^^ . . . . "Pulmonary hypertension is involved in the development of various diseases and therefore it can be caused by several mechanisms from a simple pressure elevation in the pulmonary artery to the serious impairments of pulmonary vessels. The algorism of pharmacotherapy results from the test of acute pulmonary vasodilation. Only the patients with positive test are indicated to the treatment with high doses of calcium channel blockers. Patients with negative test receive beside the chronic anticoagulation therapy also a specific pharmacotherapy (prostanoids, antagonists of endotheline receptors, etc) with not only vasodilatory but also with antiproliferative and antiaggregatory effects. When all possibilities of pharmacotherapy are exhausted, balloon atrial septostomy or lung transplantation should be considered. Method of choice in the treatment of chronic thromboembolic pulmonary hypertension is the pulmonary endarterectomy in patients with surgically curable thrombotic obstruction."@en . "CZ - \u010Cesk\u00E1 republika" . "6"^^ . . "Jansa, Pavel" . . "RIV/00216208:11110/09:4830" . . "Pulmonary hypertension; pharmacotherapy; pulmonary endarterectomy; lung transplantation"@en . "Aschermann, Michael" . . . . . "Jel\u00EDnkov\u00E1, Ludmila" .