. "Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1"@en . . . . "Resveratrol; tert-butylhydroperoxide; hepatocyte; Nitric oxide; Hemoxygenase-1"@en . . "Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1" . . "Nitric Oxide" . "RIV/00216208:11110/09:3832" . . . "1089-8603" . . . "Z\u00EDdek, Zden\u011Bk" . "1" . . "000261231600001" . "7"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "\u010Cern\u00FD, Dalibor" . "Kutinov\u00E1-Canov\u00E1, Nikolina" . "[146A985837EC]" . "The aim of this work was to study the effects of resveratrol (RES) as compared to silymarin (SM) pretreatments on tert-butylhydroperoxide (tBH) induced apoptotic/necrotic markers in hepatocytes. Hepatocyte in cultures (48 h) and in perifused immobilized agarose threads (5 h) were used as cellular systems. Hepatocyte apoptosis was estimated morphologically using Annexin-V combined with propidium iodide, or toluidine blue staining. Hepatocyte viability and functionality were evaluated by ALT and urea synthesis. Nitric oxide (NO) and carbon monoxide involvements were also examined. Resveratrol and silymarin reduced tBH-induced hepatocyte toxic effects in short term experiments (5 h) as measured by a significant reduction in ALT and NO increase produced by tBH. Both inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression were increased by tBH and reduced by both RES and SM pretreatments." . . "Ho\u0159\u00EDnek, Ale\u0161" . . . "5"^^ . "Mart\u00EDnek, Jind\u0159ich" . . "312434" . "20" . . . "Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1"@en . "8"^^ . . "The aim of this work was to study the effects of resveratrol (RES) as compared to silymarin (SM) pretreatments on tert-butylhydroperoxide (tBH) induced apoptotic/necrotic markers in hepatocytes. Hepatocyte in cultures (48 h) and in perifused immobilized agarose threads (5 h) were used as cellular systems. Hepatocyte apoptosis was estimated morphologically using Annexin-V combined with propidium iodide, or toluidine blue staining. Hepatocyte viability and functionality were evaluated by ALT and urea synthesis. Nitric oxide (NO) and carbon monoxide involvements were also examined. Resveratrol and silymarin reduced tBH-induced hepatocyte toxic effects in short term experiments (5 h) as measured by a significant reduction in ALT and NO increase produced by tBH. Both inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression were increased by tBH and reduced by both RES and SM pretreatments."@en . . "11110" . "Farghali, Hassan" . . "Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1" . . "RIV/00216208:11110/09:3832!RIV10-MZ0-11110___" . . "Kmon\u00ED\u010Dkov\u00E1, Eva" . . "P(1M0508), P(GA305/07/0061), P(NR9379), Z(AV0Z50390512), Z(MSM0021620807)" . . .