"12299" . "228"^^ . . "The ftal origin of civilization disorders concept favors the idea of prenatal programming of adult age diseases such as hypertension. Patients with advanced chronic heart failure or other and-stage diseases often have increased AngII levels and cachexia, and angiotensin-converting enzyme (ACE) inhibitor treatment improves weight loss. In this cross-sectional association study, we investigated possible associations of ACE ID and AGT M235T polymorphisms with occurence of idiopathic, non-syndromic intrauterine growth restriction (IUGR) and/or preeclampsia. No significant differences in single genotype distributions or allelic frequencies of both ACE ID and AGT M235T polymorphisms were observed between studied cohorts. However, the double heterozygosity (ID/MT) was significantly associated with lower prevalence of IUGR. The single genotypes for ACE ID or AGT M235T genes do not seem to increase the risk of preeclampsia or IUGR in pregnanacy. Despite the small sample size, the present study supports the idea of protective effect of combined heterozygotes (ID/MT) against the IUGR development risk." . "Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite?"@en . . "11"^^ . "Bienertov\u00E1-Va\u0161k\u016F, Julie" . . "preeclampsia; ACE ID and AGT M235t polymorphisms; pregnancy"@en . . "New York" . "Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite?" . . "4"^^ . . "Nova Science Publishers" . . "RIV/00209805:_____/14:#0000592" . "P(ED2.1.00/03.0101), Z(MZ0MOU2005)" . . "1"^^ . . "Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite?"@en . "https://www.novapublishers.com/catalog/product_info.php?products_id=48036&osCsid=b" . . . . "Double heterozygotes for ACE ID and AGT M235t polymorphisms are in lower risk of developing non-syndromic intrauterine growth restriction: a possible role of appetite?" . "Appetite: regulation, use of stimulants and cultural and biological influences" . . . . "[321E24DC5C6A]" . . "The ftal origin of civilization disorders concept favors the idea of prenatal programming of adult age diseases such as hypertension. Patients with advanced chronic heart failure or other and-stage diseases often have increased AngII levels and cachexia, and angiotensin-converting enzyme (ACE) inhibitor treatment improves weight loss. In this cross-sectional association study, we investigated possible associations of ACE ID and AGT M235T polymorphisms with occurence of idiopathic, non-syndromic intrauterine growth restriction (IUGR) and/or preeclampsia. No significant differences in single genotype distributions or allelic frequencies of both ACE ID and AGT M235T polymorphisms were observed between studied cohorts. However, the double heterozygosity (ID/MT) was significantly associated with lower prevalence of IUGR. The single genotypes for ACE ID or AGT M235T genes do not seem to increase the risk of preeclampsia or IUGR in pregnanacy. Despite the small sample size, the present study supports the idea of protective effect of combined heterozygotes (ID/MT) against the IUGR development risk."@en . "978-1-63117-241-0" . . "RIV/00209805:_____/14:#0000592!RIV15-MSM-00209805" .