. "CZ - \u010Cesk\u00E1 republika" . . . . . "5" . "0009-2770" . "nucleic acids electrochemistry; history; chromosomal and plasmid DNA; transfer and viral RNA; DNA labeling; mercury and solid electrodes; DMA modified electrodes; polarography; voltammetry; chronopotentiometry"@en . "Chemick\u00E9 listy" . "55 let elektrochemie nukleov\u00FDch kyselin"@cs . "108" . "P(ED2.1.00/03.0101)" . . "55 let elektrochemie nukleov\u00FDch kyselin" . . . "[595E3CDA4F94]" . "Elektrochemie nukleov\u00FDch kyselin p\u0159edstavuje je prudce se rozv\u00EDjej\u00EDc\u00ED obor, kter\u00FD v sou\u010Dasn\u00E9 dob\u011B produkuje kolem 800 prac\u00ED za rok. Prvn\u00ED pr\u00E1ce byly publikov\u00E1ny mezi lety 1958-1961 v Brn\u011B (\u010Cesk\u00E1 republika) a ukazovaly, \u017Ee rezidua purinov\u00FDch a pyrimidinov\u00FDch b\u00E1z\u00ED se v jedno\u0159et\u011Bzcov\u00E9 DNA a RNA redukuj\u00ED na Hg elektrod\u00E1ch. V nativn\u00ED dvou\u0161roubovicov\u00E1 DNA jsou redukovateln\u00E9 A a C baze ukryty uvnit\u0159 jej\u00ED struktury a jejich redukovatelnost obt\u00ED\u017En\u00E1. V t\u00E9 dob\u011B oscilografick\u00E1 polarografie prokazovala vysokou citlivost ke zm\u011Bn\u00E1m struktury DNA a dovolila sledovat denatiraci DNA a hybridizaci. S postupem \u010Dasu byly vyvinuty dal\u0161\u00ED elektrochemick\u00E9 metody a elektrody a z\u00E1kladn\u00ED principy odhalen\u00E9 b\u011Bhem dal\u0161\u00EDch t\u0159iceti let jsou nyn\u00ED vyu\u017E\u00EDv\u00E1ny k v\u00FDvoji DNA hybridiza\u010Dn\u00EDch senzor\u016F."@cs . "Elektrochemie nukleov\u00FDch kyselin p\u0159edstavuje je prudce se rozv\u00EDjej\u00EDc\u00ED obor, kter\u00FD v sou\u010Dasn\u00E9 dob\u011B produkuje kolem 800 prac\u00ED za rok. Prvn\u00ED pr\u00E1ce byly publikov\u00E1ny mezi lety 1958-1961 v Brn\u011B (\u010Cesk\u00E1 republika) a ukazovaly, \u017Ee rezidua purinov\u00FDch a pyrimidinov\u00FDch b\u00E1z\u00ED se v jedno\u0159et\u011Bzcov\u00E9 DNA a RNA redukuj\u00ED na Hg elektrod\u00E1ch. V nativn\u00ED dvou\u0161roubovicov\u00E1 DNA jsou redukovateln\u00E9 A a C baze ukryty uvnit\u0159 jej\u00ED struktury a jejich redukovatelnost obt\u00ED\u017En\u00E1. V t\u00E9 dob\u011B oscilografick\u00E1 polarografie prokazovala vysokou citlivost ke zm\u011Bn\u00E1m struktury DNA a dovolila sledovat denatiraci DNA a hybridizaci. S postupem \u010Dasu byly vyvinuty dal\u0161\u00ED elektrochemick\u00E9 metody a elektrody a z\u00E1kladn\u00ED principy odhalen\u00E9 b\u011Bhem dal\u0161\u00EDch t\u0159iceti let jsou nyn\u00ED vyu\u017E\u00EDv\u00E1ny k v\u00FDvoji DNA hybridiza\u010Dn\u00EDch senzor\u016F." . "10"^^ . "RIV/00209805:_____/14:#0000583" . . "Pale\u010Dek, Emil" . . . "Electrochemistry of nucleic acid is at present a booming field producing about 800 papers published per year. First papers in this field were published in 1958\u20131961 in Brno (Czech Republic) showing that purine and pyrimidine base residues in single-stranded DNA and RNA were reduced at Hg electrodes and the guanine residue produced an anodic signal when cyclic modes were used. The reduction sites of the base residues in native double-stranded (ds) DNA are hidden in the interior of the dsDNA molecule, which made their reduction difficult. At that time oscillographic polarography (ac chronopotentiometry) showed excellent sensitivity to changes in DNA structure and allowed to investigate DNA denaturation and hybridization. Later on also other electrochemical methods and electrodes were applied. In the following three decades basic principles were found which are at present used in the development of DNA hybridization sensors."@en . . "55 let elektrochemie nukleov\u00FDch kyselin"@cs . . . "55 years of nucleic acid electrochemistry"@en . "1"^^ . "55 years of nucleic acid electrochemistry"@en . "3"^^ . . . . "55 let elektrochemie nukleov\u00FDch kyselin" . "58332" . "http://www.chemicke-listy.cz/docs/full/2014_05_490-499.pdf" . . . . . "RIV/00209805:_____/14:#0000583!RIV15-MSM-00209805" . .