"Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 1 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs11116446171 at 6p25.3 (EXOC2; P = 2.33 x 10-21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10-10), rs79480871 1 at 2p23.3 (NCOA1; P = 4.23 x 10-8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 1 (PVT1; P = 9.98 x 10-13 and 3.63 x 10-11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL." . . "122"^^ . "RIV/00209805:_____/14:#0000575!RIV15-MSM-00209805" . "Cerhan, James R." . "Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 1 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs11116446171 at 6p25.3 (EXOC2; P = 2.33 x 10-21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10-10), rs79480871 1 at 2p23.3 (NCOA1; P = 4.23 x 10-8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 1 (PVT1; P = 9.98 x 10-13 and 3.63 x 10-11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL."@en . "18142" . "Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma" . . . "Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma"@en . . "6"^^ . . . "Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma" . "[2A69C8309872]" . "http://www.nature.com/ng/journal/v46/n11/full/ng.3105.html" . "Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma"@en . "RIV/00209805:_____/14:#0000575" . "10.1038/ng.3105" . "SNP; HLA variants; meta-analysis"@en . . "11" . . "CZ - \u010Cesk\u00E1 republika" . "I, P(ED2.1.00/03.0101)" . "46" . . . . . . . "Foretov\u00E1, Lenka" . "1061-4036" . "Nature genetics" . . . "1"^^ .