"29358" . . "Mikroprost\u0159ed\u00ED n\u00E1doru - mo\u017Enosti v\u00FDzkumu v podm\u00EDnk\u00E1ch in vitro" . "Klinick\u00E1 onkologie" . "5"^^ . "CZ - \u010Cesk\u00E1 republika" . . "http://www.linkos.cz/files/klinicka-onkologie/186/4479.pdf" . "4"^^ . . "supplementum 1" . "Mikroprost\u0159ed\u00ED n\u00E1doru - mo\u017Enosti v\u00FDzkumu v podm\u00EDnk\u00E1ch in vitro"@cs . . "RIV/00209805:_____/14:#0000528!RIV15-MSM-00209805" . "Tumor microenvironment - possibilities of the research under in vitro conditions"@en . "Tumorigenesis is always accompanied by alterations of the microenvironment in the respective tissue. The tumor microenvironment represents a heterogeneous complex, in which cell proliferation, differentiation, necrosis or apoptosis are regulated by various extracellular stimuli, and it can also lead to development of an aggressive phenotype of tumor cells. Influence of tumor microenvironment is also often connected with resistance to frequently used therapeutic procedures. Specifics of the tumor microenvironment are closely associated with the structural and functional abnormalities of tumor microvessels and altered cellular metabolism. Moreover, changes such as increase in glycolysis, elevated glucose uptake, production of lactate and CO2, and presence of hypoxic regions and regions with acidic pH are typical features of tumor tissues. At present, there is a lot of methods for in vitro simulation and investigation of some of these specific conditions, and a number of new methods are being developed. A detailed understanding of the specifics of the tumor microenvironment should increasingly improve the development of new treatment possibilities of human cancers."@en . . "Tumorogeneze je v\u017Edy doprov\u00E1zena zm\u011Bnami v mikroprost\u0159ed\u00ED p\u0159\u00EDslu\u0161n\u00E9 tk\u00E1n\u011B. N\u00E1dorov\u00E9 mikroprost\u0159ed\u00ED p\u0159edstavuje heterogenn\u00ED komplex, kter\u00FD \u0161irokou \u0161k\u00E1lou vn\u011Bj\u0161\u00EDch podn\u011Bt\u016F kontroluje bun\u011B\u010Dnou proliferaci, diferenciaci, nekr\u00F3zu nebo apopt\u00F3zu a m\u016F\u017Ee v\u00E9st k v\u00FDvoji agresivn\u00EDho fenotypu bun\u011Bk n\u00E1doru. Vliv n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED je tak\u00E9 \u010Dasto spojov\u00E1n s rezistenc\u00ED k b\u011B\u017En\u011B pou\u017E\u00EDvan\u00FDm l\u00E9\u010Debn\u00FDm postup\u016Fm. Specifi ka n\u00E1dorov\u00E9ho prost\u0159ed\u00ED jsou t\u011Bsn\u011B spojena se strukturn\u00EDmi i funk\u010Dn\u00EDmi abnormalitami c\u00E9vn\u00ED s\u00EDt\u011B v n\u00E1doru, stejn\u011B jako se zm\u011Bnami v bun\u011B\u010Dn\u00E9m metabolizmu. Pro n\u00E1dorov\u00E9 tk\u00E1n\u011B je typick\u00E9 zejm\u00E9na zv\u00FD\u0161en\u00ED pod\u00EDlu glykol\u00FDzy, zv\u00FD\u0161en\u00FD p\u0159\u00EDjem gluk\u00F3zy, produkce lakt\u00E1tu a CO2, rovn\u011B\u017E jako p\u0159\u00EDtomnost hypoxick\u00FDch oblast\u00ED a oblast\u00ED se sn\u00ED\u017Een\u00FDm pH. V sou\u010Dasn\u00E9 dob\u011B existuje mno\u017Estv\u00ED metod vhodn\u00FDch pro in vitro simulaci a v\u00FDzkum n\u011Bkter\u00FDch z t\u011Bchto podm\u00EDnek a mno\u017Estv\u00ED nov\u00FDch metod se nad\u00E1le vyv\u00EDj\u00ED. Bli\u017E\u0161\u00ED pozn\u00E1n\u00ED specifik n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED tak bude st\u00E1le v\u00EDce ovliv\u0148ovat v\u00FDvoj nov\u00FDch l\u00E9\u010Debn\u00FDch prost\u0159edk\u016F pro n\u00E1dorov\u00E1 onemocn\u011Bn\u00ED u \u010Dlov\u011Bka."@cs . "Chovanov\u00E1, Silvia" . "1"^^ . . "Sl\u00E1vikov\u00E1, V." . . . "Tumorogeneze je v\u017Edy doprov\u00E1zena zm\u011Bnami v mikroprost\u0159ed\u00ED p\u0159\u00EDslu\u0161n\u00E9 tk\u00E1n\u011B. N\u00E1dorov\u00E9 mikroprost\u0159ed\u00ED p\u0159edstavuje heterogenn\u00ED komplex, kter\u00FD \u0161irokou \u0161k\u00E1lou vn\u011Bj\u0161\u00EDch podn\u011Bt\u016F kontroluje bun\u011B\u010Dnou proliferaci, diferenciaci, nekr\u00F3zu nebo apopt\u00F3zu a m\u016F\u017Ee v\u00E9st k v\u00FDvoji agresivn\u00EDho fenotypu bun\u011Bk n\u00E1doru. Vliv n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED je tak\u00E9 \u010Dasto spojov\u00E1n s rezistenc\u00ED k b\u011B\u017En\u011B pou\u017E\u00EDvan\u00FDm l\u00E9\u010Debn\u00FDm postup\u016Fm. Specifi ka n\u00E1dorov\u00E9ho prost\u0159ed\u00ED jsou t\u011Bsn\u011B spojena se strukturn\u00EDmi i funk\u010Dn\u00EDmi abnormalitami c\u00E9vn\u00ED s\u00EDt\u011B v n\u00E1doru, stejn\u011B jako se zm\u011Bnami v bun\u011B\u010Dn\u00E9m metabolizmu. Pro n\u00E1dorov\u00E9 tk\u00E1n\u011B je typick\u00E9 zejm\u00E9na zv\u00FD\u0161en\u00ED pod\u00EDlu glykol\u00FDzy, zv\u00FD\u0161en\u00FD p\u0159\u00EDjem gluk\u00F3zy, produkce lakt\u00E1tu a CO2, rovn\u011B\u017E jako p\u0159\u00EDtomnost hypoxick\u00FDch oblast\u00ED a oblast\u00ED se sn\u00ED\u017Een\u00FDm pH. V sou\u010Dasn\u00E9 dob\u011B existuje mno\u017Estv\u00ED metod vhodn\u00FDch pro in vitro simulaci a v\u00FDzkum n\u011Bkter\u00FDch z t\u011Bchto podm\u00EDnek a mno\u017Estv\u00ED nov\u00FDch metod se nad\u00E1le vyv\u00EDj\u00ED. Bli\u017E\u0161\u00ED pozn\u00E1n\u00ED specifik n\u00E1dorov\u00E9ho mikroprost\u0159ed\u00ED tak bude st\u00E1le v\u00EDce ovliv\u0148ovat v\u00FDvoj nov\u00FDch l\u00E9\u010Debn\u00FDch prost\u0159edk\u016F pro n\u00E1dorov\u00E1 onemocn\u011Bn\u00ED u \u010Dlov\u011Bka." . . "RIV/00209805:_____/14:#0000528" . . "Mikroprost\u0159ed\u00ED n\u00E1doru - mo\u017Enosti v\u00FDzkumu v podm\u00EDnk\u00E1ch in vitro" . "Tumor microenvironment - possibilities of the research under in vitro conditions"@en . "P(ED2.1.00/03.0101)" . . . . . . "tumor microenvironment; hypoxia; acidic pH; glucose deprivation; in vitro conditions"@en . "Mikroprost\u0159ed\u00ED n\u00E1doru - mo\u017Enosti v\u00FDzkumu v podm\u00EDnk\u00E1ch in vitro"@cs . "27" . . "Chlapek, Petr" . "0862-495X" . . "Veselsk\u00E1, Renata" . "[0D76CB384A3B]" .