. . "RIV/00209805:_____/13:#0000446!RIV14-MZ0-00209805" . . "Obermannov\u00E1, Radka" . "Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients" . . "DPD genotyping; polymorphism; fluoropyrimidines; toxicity"@en . "RIV/00209805:_____/13:#0000446" . . "Dihydropyrimidine dehydrogenase is a key enzyme involved in the metabolism of fluoropyrimidine anticancer drugs. Several studies have demonstrated that diminished DPD activity as a consequence of genetic variations in the DPYD gene limits carrier\u00B4s ability to fully metabolize the drug, resulting in toxicity and adverse events. DPYD*2A (IVS14+1G > A) represents the most abundant variant allele in the European Caucasian population. Cancer patients with this gene variant represent a subgroup with higher risk of toxicity when treated with fluoropyrimidines. Therefore, we have implemented a method for DPYD*2A allele genotyping. In our pilot study performed in a group of individuals derived from our regional reference population, we found that none out of 47 subjects was a carrier of the DPYD*2A variant allele." . "Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients" . "CZ - \u010Cesk\u00E1 republika" . . "Val\u00EDk, Dalibor" . "Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients"@en . "[C73279AC489A]" . "Dihydropyrimidine dehydrogenase is a key enzyme involved in the metabolism of fluoropyrimidine anticancer drugs. Several studies have demonstrated that diminished DPD activity as a consequence of genetic variations in the DPYD gene limits carrier\u00B4s ability to fully metabolize the drug, resulting in toxicity and adverse events. DPYD*2A (IVS14+1G > A) represents the most abundant variant allele in the European Caucasian population. Cancer patients with this gene variant represent a subgroup with higher risk of toxicity when treated with fluoropyrimidines. Therefore, we have implemented a method for DPYD*2A allele genotyping. In our pilot study performed in a group of individuals derived from our regional reference population, we found that none out of 47 subjects was a carrier of the DPYD*2A variant allele."@en . . "6"^^ . . . . . "Zdra\u017Eilov\u00E1 Dubsk\u00E1, Lenka" . . "68727" . . "2" . "0085-0748" . . "49" . "Pil\u00E1tov\u00E1, Kate\u0159ina" . . "Detection of DPYD*2A allele in dihydropyrimidine dehydrogenase gene: perspective for fluoropyrimidine-treated patients"@en . . "5"^^ . . "http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-09.pdf" . . "Folia Mendeliana" . . "I, P(ED2.1.00/03.0101), P(LM2010004)" . . . . "5"^^ . . "Mrkvicov\u00E1, Martina" .