. . . . "Nekulov\u00E1, Miroslava" . . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "8"^^ . "23" . "RIV/00209805:_____/13:#0000426" . "10.1016/j.bmcl.2013.08.046" . "A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway"@en . "58461" . "http://dx.doi.org/10.1016/j.bmcl.2013.08.046" . "Reactivation of the wild-type p53 pathway is one key goal aimed at developing targeted therapeutics in the cancer research field. Although most p53 protein kinases form \u00B4p53-activating\u00B4 signals, there are few kinases whose action can contribute to the inhibition of p53, as Casein kinase 1 (CK1) and Checkpoint kinase 1 (CHK1). Here we report on a pyrazolo-pyridine analogue showing activity against both CK1 and CHK1 kinases that lead to p53 pathway stabilisation, thus having pharmacological similarities to the p53-activator Nutlin-3. These data demonstrate the emerging potential utility of multivalent kinase inhibitors." . . . . "A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway" . "Vojt\u011B\u0161ek, Bo\u0159ivoj" . . "0960-894X" . . . "RIV/00209805:_____/13:#0000426!RIV14-GA0-00209805" . "000324304000021" . . "[637594E7D23F]" . "9"^^ . . . "20" . . "kinase inhibitor; p53 Pathway activation; casein kinase 1; checkpoint kinase 1"@en . . "Bioorganic and Medicinal Chemistry Letters" . "Reactivation of the wild-type p53 pathway is one key goal aimed at developing targeted therapeutics in the cancer research field. Although most p53 protein kinases form \u00B4p53-activating\u00B4 signals, there are few kinases whose action can contribute to the inhibition of p53, as Casein kinase 1 (CK1) and Checkpoint kinase 1 (CHK1). Here we report on a pyrazolo-pyridine analogue showing activity against both CK1 and CHK1 kinases that lead to p53 pathway stabilisation, thus having pharmacological similarities to the p53-activator Nutlin-3. These data demonstrate the emerging potential utility of multivalent kinase inhibitors."@en . "A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway"@en . "2"^^ . . "I, P(ED2.1.00/03.0101), P(GAP301/11/1678), P(GBP206/12/G151)" . . "A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway" .