"Hrstka, Roman" . "Hypoxia and p53"@en . "RIV/00209805:_____/12:#0000331" . . . "24"^^ . . . . . "Peter Lang" . "140146" . "The TP53 gene has a major role as an intgerator of cellular stresses and is commnly mutated or inactivated in human cancers. As well as inducing growth arrest and cell death by transcriptional activation of target genes after genotoxic stress, p53 also responds to hypoxia. Under hypoxic conditions, p53 acts largely as a transcriptional repressor but also enhancer HUF-1-mediated activation of apoptosis. Mutation to TP53 in tumours allows increased survival in hypoxia, suggesting that these pathways could be therapeutically useful. The two other members of the p53-family, p63 and p73, also influence hypoxic responses in poorly defined ways." . "RIV/00209805:_____/12:#0000331!RIV13-MSM-00209805" . "Hypoxia and p53" . . "Vojt\u011B\u0161ek, Bo\u0159ivoj" . . . . "Tumour hypoxia: molecular mechanism and clinical implications" . "The TP53 gene has a major role as an intgerator of cellular stresses and is commnly mutated or inactivated in human cancers. As well as inducing growth arrest and cell death by transcriptional activation of target genes after genotoxic stress, p53 also responds to hypoxia. Under hypoxic conditions, p53 acts largely as a transcriptional repressor but also enhancer HUF-1-mediated activation of apoptosis. Mutation to TP53 in tumours allows increased survival in hypoxia, suggesting that these pathways could be therapeutically useful. The two other members of the p53-family, p63 and p73, also influence hypoxic responses in poorly defined ways."@en . . "Hypoxia and p53"@en . . . . "Hypoxia and p53" . "978-3-631-63991-7" . "556"^^ . "hypoxia; p53 protein family; TP53 gene; HIF; apoptosis; angiogenesis; chaperone"@en . "M\u00FCller, Petr" . . . . . . "P(ED2.1.00/03.0101), P(NT13794), Z(MZ0MOU2005)" . "http://www.peterlang.com/index.cfm?cid=165#5500758" . . "[C30169D61901]" . . "4"^^ . . . "Frankfurt am Main" . "3"^^ . .