. "14" . . . . "Karcinom ovaria"@cs . "144365" . "1212-4184" . . "Karcinom ovaria" . "Karcinom ovaria"@cs . . . "Epiteli\u00E1ln\u00ED ovari\u00E1ln\u00ED karcinom m\u00E1 v \u010Cesk\u00E9 republice z gynekologick\u00FDch zhoubn\u00FDch n\u00E1dor\u016F nejvy\u0161\u0161\u00ED mortalitu. Preventivn\u00ED opat\u0159en\u00ED a screening jsou st\u00E1le p\u0159edm\u011Btem zkoum\u00E1n\u00ED. V\u011Bt\u0161ina pacientek je vzhledem k nespecifick\u00FDm symptom\u016Fm diagnostikov\u00E1na v pokro\u010Dil\u00E9m stadiu nemoci. \u00DAvodn\u00ED l\u00E9\u010Dba karcinomu ovaria spo\u010D\u00EDvaj\u00EDc\u00ED v prim\u00E1rn\u00ED cytoreduk\u010Dn\u00ED operaci v kombinaci s adjuvantn\u00ED chemoterapi\u00ED na b\u00E1zi platiny a paklitaxelu dosahuje vysok\u00E9 l\u00E9\u010Debn\u00E9 odpov\u011Bdi. P\u0159esto zhruba u dvou t\u0159etin pacientek doch\u00E1z\u00ED k relapsu nemoci, rozvoji chemorerezistence a \u00FAmrt\u00ED. Tyto \u00FAdaje vedou k hled\u00E1n\u00ED nov\u00FDch metod v l\u00E9\u010Db\u011B karcinomu ovaria. Jednou z nov\u00FDch mo\u017Enost\u00ED l\u00E9\u010Dby, kter\u00E1 je zkoum\u00E1na v l\u00E9\u010Db\u011B karcinomu ovaria jsou l\u00E1tky blokuj\u00EDc\u00ED angiogenezi." . "RIV/00209805:_____/12:#0000325" . "http://zdravi.e15.cz/archiv/postgradualni-medicina/?id=3852" . . "ovarian cancer; epidemiology; diagnostics; therapy"@en . "Epithelial ovarian cancer remains the most lethal gynaecologic malignancy in Czech republic. Prevention and screening strategies are a subject of continuous research. Due to the nonspecific symptoms of the disease, the majority of the cases are diagnosed only in advanced stages. The first line of treatment of ovarian cancer involves a primary cytoreductive surgery, followed by combined adjuvant chemotherapy, based on platinum and paclixatel, which generally achieves a good therapeutic response. However, in about two thirds of the patients, the disease relapses, chemo-resistance develops and the patient ultimately dies. This has prompted the search for new strategies for treatment of ovarian cancer. Antiangiogenics represent represent one of the new classes of drugs that are being evaluated for use in treatment of ovarian cancer."@en . "1"^^ . "Epiteli\u00E1ln\u00ED ovari\u00E1ln\u00ED karcinom m\u00E1 v \u010Cesk\u00E9 republice z gynekologick\u00FDch zhoubn\u00FDch n\u00E1dor\u016F nejvy\u0161\u0161\u00ED mortalitu. Preventivn\u00ED opat\u0159en\u00ED a screening jsou st\u00E1le p\u0159edm\u011Btem zkoum\u00E1n\u00ED. V\u011Bt\u0161ina pacientek je vzhledem k nespecifick\u00FDm symptom\u016Fm diagnostikov\u00E1na v pokro\u010Dil\u00E9m stadiu nemoci. \u00DAvodn\u00ED l\u00E9\u010Dba karcinomu ovaria spo\u010D\u00EDvaj\u00EDc\u00ED v prim\u00E1rn\u00ED cytoreduk\u010Dn\u00ED operaci v kombinaci s adjuvantn\u00ED chemoterapi\u00ED na b\u00E1zi platiny a paklitaxelu dosahuje vysok\u00E9 l\u00E9\u010Debn\u00E9 odpov\u011Bdi. P\u0159esto zhruba u dvou t\u0159etin pacientek doch\u00E1z\u00ED k relapsu nemoci, rozvoji chemorerezistence a \u00FAmrt\u00ED. Tyto \u00FAdaje vedou k hled\u00E1n\u00ED nov\u00FDch metod v l\u00E9\u010Db\u011B karcinomu ovaria. Jednou z nov\u00FDch mo\u017Enost\u00ED l\u00E9\u010Dby, kter\u00E1 je zkoum\u00E1na v l\u00E9\u010Db\u011B karcinomu ovaria jsou l\u00E1tky blokuj\u00EDc\u00ED angiogenezi."@cs . "Karcinom ovaria" . "Chovanec, Josef" . "7"^^ . "1"^^ . . "Ovarian cancer"@en . . "CZ - \u010Cesk\u00E1 republika" . . "Postgradu\u00E1ln\u00ED medic\u00EDna" . "P(ED2.1.00/03.0101)" . . . . "RIV/00209805:_____/12:#0000325!RIV13-MSM-00209805" . . "Ovarian cancer"@en . "9" . . . "[8ED3FE7B804B]" .