. . . "Foretov\u00E1, Lenka" . . . . "Preventing hereditary risk of breast and ovarian cancer"@en . "1"^^ . . . . "223212" . . . "1211-6645" . "1"^^ . "http://www.prolekare.cz/prakticka-gynekologie-clanek/prevence-dedicneho-rizika-nadoru-prsu-a-ovaria-36357?search=foretov%C3%A1" . "Prevence d\u011Bdi\u010Dn\u00E9ho rizika n\u00E1dor\u016F prsu a ovaria"@cs . "I, Z(MZ0MOU2005)" . "Preventing hereditary risk of breast and ovarian cancer"@en . "RIV/00209805:_____/11:#0000211!RIV12-MZ0-00209805" . "3" . "Praktick\u00E1 gynekologie" . "The incidence of breast and ovarian cancer is increasing. Most cancer diseases are caused by a combination of genetic and environmental factors. Hereditary etiology, caused by a germline mutation in a high-risk gene multiplying the probability of cancer, is identified in a small proportion of patients only. Genetic testing may disclose heredity and enable us to use this knowledge for the profit of the patient and her family members. Several genes are responsible for the risk of breast or ovarian cancer. Testing of highly penetrant BRCA1 and BRCA2 genes is recommended for clinical use, the role of moderate or low-risk genes in cancer etiology is unclear. Breast or ovarian cancer may be a part of other hereditary syndromes, where the testing is also possible. Expert teams recommend preventive care for BRCA1 and BRCA2 carriers that comprises of primary prevention with prophylactic surgeries and specialized secondary prevention. Modern diagnostic methods and surgical prevention may improve survival and quality of life."@en . . "Prevence d\u011Bdi\u010Dn\u00E9ho rizika n\u00E1dor\u016F prsu a ovaria" . "15" . "CZ - \u010Cesk\u00E1 republika" . "RIV/00209805:_____/11:#0000211" . . "Incidence n\u00E1dor\u016F prsu i vaje\u010Dn\u00EDk\u016F neust\u00E1le vzr\u016Fst\u00E1. Onemocn\u011Bn\u00ED jsou zp\u016Fsobena interakc\u00ED r\u016Fzn\u00FDch genetick\u00FDch p\u0159\u00ED\u010Din a vlivu prost\u0159ed\u00ED. Pouze u \u010D\u00E1sti pacientek je mo\u017En\u00E9 zjistit d\u011Bdi\u010Dnou etiologii, tj. z\u00E1rode\u010Dnou mutaci v n\u011Bkter\u00E9m z rizikov\u00FDch gen\u016F, kter\u00E1 zp\u016Fsobuje mnohon\u00E1sobn\u011B zv\u00FD\u0161enou pravd\u011Bpodobnost onemocn\u011Bn\u00ED. Genetick\u00E9 testov\u00E1n\u00ED umo\u017E\u0148uje odhalit heredit\u00E1rn\u00ED p\u0159\u00ED\u010Dinu a vyu\u017E\u00EDt t\u011Bchto poznatk\u016F ve prosp\u011Bch jak pacientky, tak rodiny. Gen\u016F, kter\u00E9 mohou b\u00FDt zodpov\u011Bdn\u00E9 za vy\u0161\u0161\u00ED riziko n\u00E1dor\u016F prsu nebo vaje\u010Dn\u00EDku, je v\u00EDce. \u2028Z klinick\u00E9ho hlediska se doporu\u010Duje genetick\u00E9 testov\u00E1n\u00ED vysoce penetrantn\u00EDch gen\u016F BRCA1 a BRCA2, u gen\u016F st\u0159edn\u00EDho a n\u00EDzk\u00E9ho rizika je jejich vliv na etiologii onemocn\u011Bn\u00ED nejasn\u00FD. N\u00E1dory prsu nebo ovari\u00ED mohou b\u00FDt sou\u010D\u00E1st\u00ED i jin\u00FDch d\u011Bdi\u010Dn\u00FDch syndrom\u016F, kter\u00E9 je mo\u017En\u00E9 testovat. Preventivn\u00ED p\u00E9\u010De o nosi\u010Dky mutac\u00ED v genech BRCA1 a BRCA2 je navrhov\u00E1na t\u00FDmy odborn\u00EDk\u016F a zahrnuje jak prim\u00E1rn\u00ED prevenci v\u010Detn\u011B profylaktick\u00FDch operac\u00ED, tak specializovanou sekund\u00E1rn\u00ED prevenci. D\u00EDky modern\u00EDm vy\u0161et\u0159ovac\u00EDm metod\u00E1m i preventivn\u00EDm operac\u00EDm je mo\u017En\u00E9 z\u00E1sadn\u011B zv\u00FD\u0161it p\u0159e\u017Eit\u00ED \u017Een i kvalitu jejich \u017Eivota."@cs . . . "Prevence d\u011Bdi\u010Dn\u00E9ho rizika n\u00E1dor\u016F prsu a ovaria"@cs . . . "[D855F872B8E8]" . . "Incidence n\u00E1dor\u016F prsu i vaje\u010Dn\u00EDk\u016F neust\u00E1le vzr\u016Fst\u00E1. Onemocn\u011Bn\u00ED jsou zp\u016Fsobena interakc\u00ED r\u016Fzn\u00FDch genetick\u00FDch p\u0159\u00ED\u010Din a vlivu prost\u0159ed\u00ED. Pouze u \u010D\u00E1sti pacientek je mo\u017En\u00E9 zjistit d\u011Bdi\u010Dnou etiologii, tj. z\u00E1rode\u010Dnou mutaci v n\u011Bkter\u00E9m z rizikov\u00FDch gen\u016F, kter\u00E1 zp\u016Fsobuje mnohon\u00E1sobn\u011B zv\u00FD\u0161enou pravd\u011Bpodobnost onemocn\u011Bn\u00ED. Genetick\u00E9 testov\u00E1n\u00ED umo\u017E\u0148uje odhalit heredit\u00E1rn\u00ED p\u0159\u00ED\u010Dinu a vyu\u017E\u00EDt t\u011Bchto poznatk\u016F ve prosp\u011Bch jak pacientky, tak rodiny. Gen\u016F, kter\u00E9 mohou b\u00FDt zodpov\u011Bdn\u00E9 za vy\u0161\u0161\u00ED riziko n\u00E1dor\u016F prsu nebo vaje\u010Dn\u00EDku, je v\u00EDce. \u2028Z klinick\u00E9ho hlediska se doporu\u010Duje genetick\u00E9 testov\u00E1n\u00ED vysoce penetrantn\u00EDch gen\u016F BRCA1 a BRCA2, u gen\u016F st\u0159edn\u00EDho a n\u00EDzk\u00E9ho rizika je jejich vliv na etiologii onemocn\u011Bn\u00ED nejasn\u00FD. N\u00E1dory prsu nebo ovari\u00ED mohou b\u00FDt sou\u010D\u00E1st\u00ED i jin\u00FDch d\u011Bdi\u010Dn\u00FDch syndrom\u016F, kter\u00E9 je mo\u017En\u00E9 testovat. Preventivn\u00ED p\u00E9\u010De o nosi\u010Dky mutac\u00ED v genech BRCA1 a BRCA2 je navrhov\u00E1na t\u00FDmy odborn\u00EDk\u016F a zahrnuje jak prim\u00E1rn\u00ED prevenci v\u010Detn\u011B profylaktick\u00FDch operac\u00ED, tak specializovanou sekund\u00E1rn\u00ED prevenci. D\u00EDky modern\u00EDm vy\u0161et\u0159ovac\u00EDm metod\u00E1m i preventivn\u00EDm operac\u00EDm je mo\u017En\u00E9 z\u00E1sadn\u011B zv\u00FD\u0161it p\u0159e\u017Eit\u00ED \u017Een i kvalitu jejich \u017Eivota." . . "genes BRCA1, BRCA2; genetic predisposition; breast cancer; ovarian cancer; tumour preventions"@en . "Prevence d\u011Bdi\u010Dn\u00E9ho rizika n\u00E1dor\u016F prsu a ovaria" . . "7"^^ .