. . "LA-12, cisplatin, Hsp90"@en . . "Vojt\u011B\u0161ek, Bo\u0159ivoj" . "Molecular cancer" . "Kvardov\u00E1, Veronika" . "9"^^ . . "9"^^ . "The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin"@en . "Cisplatin and its derivatives are commonly used anti-cancer drugs. However, cisplatin has clinical limitations as serious side effects and frequent emergence of resistance. LA-12 shows increased intracellular penetration resulting in improved cytotoxicity in cancer cell lines, including cisplatin resistant cells. LA-12 disrupts cellular proliferation regardless of p53 status, however the potency of the drug is greatly enhanced by the presence of functional p53. Binding of LA-12 to Hsp90 was demonstrated and an inhibitory effect on Hsp90 chaperoning function was shown by decrease of Hsp90-assisted wild-type p53 binding to p21WAF1 promoter sequence in vitro and by accelerated ubiqutination and degradation of primarily unfolded mutant p53 proteins. LA-12 induced degradation of Hsp90 client proteins (Cyclin D1 and estrogen receptor) was shown and proved as more efficient compared to cisplatin." . "15.6.2010" . . "The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin" . "5"^^ . . "Cisplatin and its derivatives are commonly used anti-cancer drugs. However, cisplatin has clinical limitations as serious side effects and frequent emergence of resistance. LA-12 shows increased intracellular penetration resulting in improved cytotoxicity in cancer cell lines, including cisplatin resistant cells. LA-12 disrupts cellular proliferation regardless of p53 status, however the potency of the drug is greatly enhanced by the presence of functional p53. Binding of LA-12 to Hsp90 was demonstrated and an inhibitory effect on Hsp90 chaperoning function was shown by decrease of Hsp90-assisted wild-type p53 binding to p21WAF1 promoter sequence in vitro and by accelerated ubiqutination and degradation of primarily unfolded mutant p53 proteins. LA-12 induced degradation of Hsp90 client proteins (Cyclin D1 and estrogen receptor) was shown and proved as more efficient compared to cisplatin."@en . . "274738" . . "Hrstka, Roman" . . "M\u00FCller, Petr" . . "RIV/00209805:_____/10:#0000115" . "1476-4598" . . . "The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin" . "[4C5D7D1A9DEC]" . "P(NS9812), Z(MZ0MOU2005)" . "RIV/00209805:_____/10:#0000115!RIV11-MZ0-00209805" . "Matoulkov\u00E1, Eva" . "The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin"@en . . . . . "000279281100001" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . . . "9" . .