"6"^^ . . . "468832" . . "5"^^ . "RIV/00209805:_____/06:0000019" . . . "Vojt\u011B\u0161ek, Bo\u0159ivoj" . "Fosforylace p53 prost\u0159ednictv\u00EDm CK2 je indukov\u00E1na v baz\u00E1ln\u00EDch kmenov\u00FDch bu\u0148k\u00E1ch exprimuj\u00EDc\u00EDch (delta)Np63 v lidsk\u00E9 k\u016F\u017Ei oz\u00E1\u0159en\u00E9 UVB"@cs . . . "CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin" . "2"^^ . "5" . "Fosforylace p53 prost\u0159ednictv\u00EDm CK2 je indukov\u00E1na v baz\u00E1ln\u00EDch kmenov\u00FDch bu\u0148k\u00E1ch exprimuj\u00EDc\u00EDch (delta)Np63 v lidsk\u00E9 k\u016F\u017Ei oz\u00E1\u0159en\u00E9 UVB"@cs . . . . . . . . "[9988F4CA2394]" . "Nenutil, Rudolf" . "21" . "CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin"@en . . "Using human skin as a model, we have found a selective induction of p53 phosphorylation at the CK2-site in the basal cells of UV irradiated human skin. Given that p63(alpha)(delta)N is required for p53 activation after DNA damage, we found a high proportion of cells co-express p63\u03B1(delta)N and CK2-phosphorylated p53 after UV-irradiation. These data identify a physiological model with which to identify signaling pathways that mediate cross-talk between p63\u03B1(delta)N and activating p53 kinase pathways after DNA damage in basal cell populations."@en . . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "2489; 2494" . "S pou\u017Eit\u00EDm lidsk\u00E9 k\u016F\u017Ee jako modelu jsme prok\u00E1zali selektivn\u00ED indukci fosforylace p53 v CK2-m\u00EDst\u011B v baz\u00E1ln\u00EDch bu\u0148k\u00E1ch lidsk\u00E9 k\u016F\u017Ee oz\u00E1\u0159en\u00E9 UV. Nalezli jsme vysok\u00FD pod\u00EDl bun\u011Bk s CK2-fosforylovan\u00FDm p53, kter\u00E9 takt\u00E9\u017E exprimuj\u00ED p63(alfa)(delta)N, pot\u0159ebn\u00FD pro aktivaci v p\u0159\u00EDpad\u011B po\u0161kozen\u00ED DNA. Na z\u00E1klad\u011B dat jsme nalezli fyziologick\u00FD model sign\u00E1ln\u00EDch drah, kter\u00FD spojuje p63(alfa)(delta)N a p53 aktivuj\u00EDc\u00ED kin\u00E1zy v p\u0159\u00EDpad\u011B po\u0161kozen\u00ED DNA v baz\u00E1ln\u00ED bun\u011B\u010Dn\u00E9 populaci."@cs . "CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin"@en . "Using human skin as a model, we have found a selective induction of p53 phosphorylation at the CK2-site in the basal cells of UV irradiated human skin. Given that p63(alpha)(delta)N is required for p53 activation after DNA damage, we found a high proportion of cells co-express p63\u03B1(delta)N and CK2-phosphorylated p53 after UV-irradiation. These data identify a physiological model with which to identify signaling pathways that mediate cross-talk between p63\u03B1(delta)N and activating p53 kinase pathways after DNA damage in basal cell populations." . "1538-4101" . . "RIV/00209805:_____/06:0000019!RIV07-MZ0-00209805" . "Cell cycle" . "CK2-site phosphorylation of p53 is induced in (delta)Np63 expressing basal stem cells in UVB irradiated human skin" . "P(GA301/05/0416), P(NR8338)" . . "stem cell, p63, differentiation, p53 phosphorylation, ATM, CK2"@en .