"Kova\u0159\u00EDk, Jan" . . "7"^^ . "[E2CF7806869B]" . "Funk\u010Dn\u00ED a expresn\u00ED zm\u011Bny STAT/SOCS protein\u016F souvisej\u00EDc\u00ED s p\u016Fsoben\u00EDm interferon\u016F v bu\u0148k\u00E1ch lidsk\u00E9ho malign\u00EDho melanomu"@cs . "RIV/00209805:_____/05:0000030!RIV07-MZ0-00209805" . "522254" . "Masaryk\u016Fv onkologick\u00FD \u00FAstav" . . . "RIV/00209805:_____/05:0000030" . . . "Changes in the function and expression of STAT/SOCS proteins associated with interferon treatment in human malignant melanoma cells"@en . . . "3"^^ . "P(GA301/03/0370), P(NC7139), Z(MZ00020980501)" . . "Proteiny STAT (sign\u00E1ln\u00ED transduktory a aktiv\u00E1tory transkripce) a SOCS (supresory cytokinov\u00FDch sign\u00E1l\u016F) hraj\u00ED kl\u00ED\u010Dovou \u00FAlohu v sign\u00E1ln\u00ED transdukci cytokin\u016F. Exprese SOCS 3 /STAT 1 na \u00FArovni mRNA i proteinu byla studov\u00E1na metodou Northern a Western blotu. Bylo pou\u017Eito 18 dob\u0159e definovan\u00FDch stabilizovan\u00FDch bun\u011B\u010Dn\u00FDch lini\u00ED malign\u00EDho melanomu, jako kontrola slou\u017Eily prim\u00E1rn\u00ED kultury lidsk\u00FDch ko\u017En\u00EDch keratinocyt\u016F (2 kultury) a fibroblast\u016F (3 kultury). Bylo prok\u00E1z\u00E1no, \u017Ee IFN gama, na rozd\u00EDl od IFN alfa, \u00FA\u010Dinn\u011B indukuje expresi SOCS 3 u bun\u011Bk lidsk\u00E9ho malign\u00EDho malanomu i u nen\u00E1dorov\u00FDch bun\u011Bk (ko\u017En\u00ED fibroblasty a keratinocyty). D\u00E1le bylo zji\u0161t\u011Bno, \u017Ee hladina STAT 1 mRNA byla u melanomov\u00FDch bun\u011Bk 2-3 kr\u00E1t sn\u00ED\u017Eena v porovn\u00E1n\u00ED s kontroln\u00EDmi bu\u0148kami."@cs . . "Changes in the function and expression of STAT/SOCS proteins associated with interferon treatment in human malignant melanoma cells"@en . "3"^^ . "Proteiny STAT (sign\u00E1ln\u00ED transduktory a aktiv\u00E1tory transkripce) a SOCS (supresory cytokinov\u00FDch sign\u00E1l\u016F) hraj\u00ED kl\u00ED\u010Dovou \u00FAlohu v sign\u00E1ln\u00ED transdukci cytokin\u016F. Exprese SOCS 3 /STAT 1 na \u00FArovni mRNA i proteinu byla studov\u00E1na metodou Northern a Western blotu. Bylo pou\u017Eito 18 dob\u0159e definovan\u00FDch stabilizovan\u00FDch bun\u011B\u010Dn\u00FDch lini\u00ED malign\u00EDho melanomu, jako kontrola slou\u017Eily prim\u00E1rn\u00ED kultury lidsk\u00FDch ko\u017En\u00EDch keratinocyt\u016F (2 kultury) a fibroblast\u016F (3 kultury). Bylo prok\u00E1z\u00E1no, \u017Ee IFN gama, na rozd\u00EDl od IFN alfa, \u00FA\u010Dinn\u011B indukuje expresi SOCS 3 u bun\u011Bk lidsk\u00E9ho malign\u00EDho malanomu i u nen\u00E1dorov\u00FDch bun\u011Bk (ko\u017En\u00ED fibroblasty a keratinocyty). D\u00E1le bylo zji\u0161t\u011Bno, \u017Ee hladina STAT 1 mRNA byla u melanomov\u00FDch bun\u011Bk 2-3 kr\u00E1t sn\u00ED\u017Eena v porovn\u00E1n\u00ED s kontroln\u00EDmi bu\u0148kami." . . . "Funk\u010Dn\u00ED a expresn\u00ED zm\u011Bny STAT/SOCS protein\u016F souvisej\u00EDc\u00ED s p\u016Fsoben\u00EDm interferon\u016F v bu\u0148k\u00E1ch lidsk\u00E9ho malign\u00EDho melanomu" . . . "Brno" . . "Brno" . "2005-01-01+01:00"^^ . "STAT, SOCS, interferons, signal transduction, malignant melanoma"@en . "Boudn\u00FD, Vladim\u00EDr" . "Funk\u010Dn\u00ED a expresn\u00ED zm\u011Bny STAT/SOCS protein\u016F souvisej\u00EDc\u00ED s p\u016Fsoben\u00EDm interferon\u016F v bu\u0148k\u00E1ch lidsk\u00E9ho malign\u00EDho melanomu"@cs . "92; 94" . "STAT (signal transducers and activators of transcription) and SOCS (suppressors of cytokine signaling) proteins play a key role in cytokine signal transduction. SOCS 3 /STAT 1 expression on both mRNA and protein levels was examined by means of Northern and Western blot techniques. Eighteen well-characterized established malignant melanoma cell lines as well as 5 normal non-malignant primary cultures (2 human keratinocytes and 3 fibroblasts) were used. IFN gamma but not IFN alpha effectively induced SOCS 3 expression in malignant melanoma lines as well as in non-malignant cells (fibroblasts and keratinocytes). STAT 1 mRNA levels were 2-3 times reduced in comparison with normal cells."@en . . "Eduka\u010Dn\u00ED sborn\u00EDk: XXIX. Brn\u011Bnsk\u00E9 onkologick\u00E9 dny a XX. Konference pro sestry a laboranty" . . . "Lauerov\u00E1, Ludmila" . . . . "Funk\u010Dn\u00ED a expresn\u00ED zm\u011Bny STAT/SOCS protein\u016F souvisej\u00EDc\u00ED s p\u016Fsoben\u00EDm interferon\u016F v bu\u0148k\u00E1ch lidsk\u00E9ho malign\u00EDho melanomu" . . . "80-86793-05-2" . .