. "Kova\u0159\u00EDk, Jan" . "GR - \u0158eck\u00E1 republika" . . "RIV/00209805:_____/03:00008210!RIV/2004/GA0/L26004/N" . . . "Alterations in IFN signaling in cancer and their potential clinical impact"@en . . "[B749ACA8230F]" . . "597828" . . "STAT 1;interferons;malignant melanoma"@en . "S40" . "Boudn\u00FD, Vladim\u00EDr" . "12" . "1107-3756" . . "International journal of molecular medicine" . "Alterations in IFN signaling in cancer and their potential clinical impact" . . "1"^^ . "Alterations in IFN signaling in cancer and their potential clinical impact" . . "5"^^ . . "Alterations in IFN signaling in cancer and their potential clinical impact"@en . "P(GA301/03/0370), Z(MZ00020980501)" . . "5"^^ . "We here report on the deficient inducibility of STAT1 phosphorylation at Ser-727 and Tyr-701 in response to IFN-?\u0143/-gamma in stage II and III melanoma patients. The absence of STAT1 activation at Ser-727 occurred in three quarters of patients. Induction of STAT1 phosphorylation at Tyr-701 by IFN-alfa was lacking in 63% and by IFN-gamma in 34% of patients." . . "suppl.1" . . . "RIV/00209805:_____/03:00008210" . . . . "We here report on the deficient inducibility of STAT1 phosphorylation at Ser-727 and Tyr-701 in response to IFN-?\u0143/-gamma in stage II and III melanoma patients. The absence of STAT1 activation at Ser-727 occurred in three quarters of patients. Induction of STAT1 phosphorylation at Tyr-701 by IFN-alfa was lacking in 63% and by IFN-gamma in 34% of patients."@en .