. "Masaryk\u016Fv onkologick\u00FD \u00FAstav" . "4"^^ . "2003-05-22+02:00"^^ . . . . . . "Funk\u010Dn\u00ED anal\u00FDza n\u00E1dorov\u00E9ho supresoru p53 u akutn\u00ED myeloidn\u00ED leuk\u00E9mie" . . . . . . "Funk\u010Dn\u00ED anal\u00FDza n\u00E1dorov\u00E9ho supresoru p53 u akutn\u00ED myeloidn\u00ED leuk\u00E9mie"@cs . "Functional analysis of tumor suppressor p53 in acute myeloid leukemia"@en . "acute myeloid leukemia;tumor suppressor p53;temperature-sensitive mutants;FASAY;prognosis"@en . "607838" . . "[2FEC6BB5296B]" . "Funk\u010Dn\u00ED anal\u00FDza n\u00E1dorov\u00E9ho supresoru p53 u akutn\u00ED myeloidn\u00ED leuk\u00E9mie" . . . . "RIV/00209805:_____/03:00007937!RIV/2004/MZ0/L26004/N" . "P(NC6395), Z(MZ00020980501)" . . "XXVII. Brn\u011Bnsk\u00E9 onkologick\u00E9 dny a XVII. Konference pro sestry a laboranty: eduka\u010Dn\u00ED sborn\u00EDk" . "p53 mutation was detected in 13 of 62 tested AML cases (21 %) and in 1 of 4 MDS cases by FASAY. The presence of the p53 mutation was shown to be a poor prognostic and predictive factor in AML. 5 of 13 mutations detected in AML and the mutation detected in MDS were temperature sensitive (altogether 6/14 - 42,9 %)."@en . . "\u0160mardov\u00E1, Jana" . . "RIV/00209805:_____/03:00007937" . "3"^^ . "1"^^ . . . "Mutace p53 byla detekov\u00E1na metodou FASAY u 13/62 p\u0159\u00EDpad\u016F AML (21 %) a u 1/4 p\u0159\u00EDpad\u016F MDS. P\u0159\u00EDtomnost mutace p53 byla statisticky v\u00FDznamn\u00FDm negativn\u00EDm prognostick\u00FDm a prediktivn\u00EDm faktorem u AML. 5/13 mutac\u00ED detekovan\u00FDch u AML a mutace detekovan\u00E1 u pacienta s MDS (dohromady 6/14 - 42,9 %) bylo teplotn\u011B-senzitivn\u00EDch." . "Brno" . "89" . "Funk\u010Dn\u00ED anal\u00FDza n\u00E1dorov\u00E9ho supresoru p53 u akutn\u00ED myeloidn\u00ED leuk\u00E9mie"@cs . "Functional analysis of tumor suppressor p53 in acute myeloid leukemia"@en . "Brno" .