"Androgenn\u00ED deficit a diabetes" . . "RIV/00179906:_____/12:10128222!RIV13-MZ0-00179906" . "4"^^ . "Androgen deficit and diabetes"@en . . "substitution; metabolic syndrome; type 2 diabetes mellitus; testosterone"@en . "Androgenn\u00ED deficit a diabetes"@cs . "[E1F748F8CBA2]" . "Androgenn\u00ED deficit a diabetes" . "0042-773X" . "Low testosterone level is common in obese men and even more frequent in the presence of type 2 diabetes mellitus. Low testosterone level is probably not caused by increased aromatization of testosterone to estradiol in fat tissue. Increase of inflammation mediators, insulin and leptin resistance and low SHBG level may play more important role. Low testosterone level may manifest with low libido, erectile dysfunction, fatigue and depressive mood; it has a role in development of anaemia, osteoporosis, worsening of insulin resistance and it is probably marker of increased all-case and cardiovascular mortality. Routine investigation of testosterone level is indicated in every man with type 2 diabetes mellitus. As in non-diabetic men of middle and higher age substitution is indicated only in presence of clinical symptoms of hypogonadism. The substitution improves mainly libido, erectile dysfunction is influenced less. However, the phosphodiasterase- 5 inhibitors efficiency is markedly improved. Metabolic changes during testosterone substitution are small."@en . . . . "1"^^ . . . "N\u00EDzk\u00E1 hladina testosteronu je \u010Dast\u00E1 u ob\u00E9zn\u00EDch mu\u017E\u016F a je\u0161t\u011B \u010Dast\u011Bj\u0161\u00ED p\u0159i sou\u010Dasn\u00E9 p\u0159\u00EDtomnosti diabetu 2. typu. P\u0159\u00ED\u010Dinou pravd\u011Bpodobn\u011B nen\u00ED zv\u00FD\u0161en\u00E1 aromatizace testosteronu na estradiol v tukov\u00E9 tk\u00E1ni, d\u016Fle\u017Eit\u011Bj\u0161\u00ED roli hraje vzestup medi\u00E1tor\u016F z\u00E1n\u011Btu, rezistence k \u00FA\u010Dinku inzulinu a leptinu a tak\u00E9 n\u00EDzk\u00E1 hladina SHBG. N\u00EDzk\u00E1 hladina testosteronu se m\u016F\u017Ee projevit sn\u00ED\u017Een\u00EDm libida, erektiln\u00ED dysfunkc\u00ED, \u00FAnavou a depresivn\u00EDm lad\u011Bn\u00EDm, pod\u00EDl\u00ED se na vzniku an\u00E9mie, osteopor\u00F3zy, zhor\u0161en\u00ED inzulinov\u00E9 rezistence a je z\u0159ejm\u011B ukazatelem zv\u00FD\u0161en\u00E9 celkov\u00E9 a kardiovaskul\u00E1rn\u00ED \u00FAmrtnosti. Vy\u0161et\u0159en\u00ED hladiny testosteronu je indikov\u00E1no u v\u0161ech mu\u017E\u016F s diabetem 2. typu. Analogicky jako u mu\u017E\u016F st\u0159edn\u00EDho a vy\u0161\u0161\u00EDho v\u011Bku bez diabetu je substituce indikov\u00E1na jen tam, kde jsou p\u0159\u00EDtomny klinick\u00E9 p\u0159\u00EDznaky hypogonadizmu. Substituce zlep\u0161uje p\u0159edev\u0161\u00EDm libido, m\u00E9n\u011B poruchy erekce. Zvy\u0161uje v\u0161ak \u00FA\u010Dinnost inhibitor\u016F fosfodiester\u00E1zy 5. Metabolick\u00E9 \u00FA\u010Dinky jsou p\u0159i substituci mal\u00E9." . . "RIV/00179906:_____/12:10128222" . "58" . "1"^^ . "N\u00EDzk\u00E1 hladina testosteronu je \u010Dast\u00E1 u ob\u00E9zn\u00EDch mu\u017E\u016F a je\u0161t\u011B \u010Dast\u011Bj\u0161\u00ED p\u0159i sou\u010Dasn\u00E9 p\u0159\u00EDtomnosti diabetu 2. typu. P\u0159\u00ED\u010Dinou pravd\u011Bpodobn\u011B nen\u00ED zv\u00FD\u0161en\u00E1 aromatizace testosteronu na estradiol v tukov\u00E9 tk\u00E1ni, d\u016Fle\u017Eit\u011Bj\u0161\u00ED roli hraje vzestup medi\u00E1tor\u016F z\u00E1n\u011Btu, rezistence k \u00FA\u010Dinku inzulinu a leptinu a tak\u00E9 n\u00EDzk\u00E1 hladina SHBG. N\u00EDzk\u00E1 hladina testosteronu se m\u016F\u017Ee projevit sn\u00ED\u017Een\u00EDm libida, erektiln\u00ED dysfunkc\u00ED, \u00FAnavou a depresivn\u00EDm lad\u011Bn\u00EDm, pod\u00EDl\u00ED se na vzniku an\u00E9mie, osteopor\u00F3zy, zhor\u0161en\u00ED inzulinov\u00E9 rezistence a je z\u0159ejm\u011B ukazatelem zv\u00FD\u0161en\u00E9 celkov\u00E9 a kardiovaskul\u00E1rn\u00ED \u00FAmrtnosti. Vy\u0161et\u0159en\u00ED hladiny testosteronu je indikov\u00E1no u v\u0161ech mu\u017E\u016F s diabetem 2. typu. Analogicky jako u mu\u017E\u016F st\u0159edn\u00EDho a vy\u0161\u0161\u00EDho v\u011Bku bez diabetu je substituce indikov\u00E1na jen tam, kde jsou p\u0159\u00EDtomny klinick\u00E9 p\u0159\u00EDznaky hypogonadizmu. Substituce zlep\u0161uje p\u0159edev\u0161\u00EDm libido, m\u00E9n\u011B poruchy erekce. Zvy\u0161uje v\u0161ak \u00FA\u010Dinnost inhibitor\u016F fosfodiester\u00E1zy 5. Metabolick\u00E9 \u00FA\u010Dinky jsou p\u0159i substituci mal\u00E9."@cs . "I" . "122760" . "Androgenn\u00ED deficit a diabetes"@cs . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . . . "3" . . "CZ - \u010Cesk\u00E1 republika" . "\u010C\u00E1p, Jan" . . . "Androgen deficit and diabetes"@en . . . .