. . . . . . "V\u00FDznam stanoven\u00ED FLC u nemocn\u00FDch MGUS a v kompletn\u00ED remisi u mnoho\u010Detn\u00E9ho myelomu"@cs . "Klinick\u00E1 biochemie a metabolismus" . "Tich\u00FD, Milo\u0161" . "[87D63A76399E]" . . "\u0160pi\u010Dka, I." . "CZ - \u010Cesk\u00E1 republika" . "V\u00FDznam stanoven\u00ED FLC u nemocn\u00FDch MGUS a v kompletn\u00ED remisi u mnoho\u010Detn\u00E9ho myelomu" . "N\u00E1\u0161 projekt byl zam\u011B\u0159en na anal\u00FDzu mo\u017En\u00E9ho vyu\u017Eit\u00ED stanoven\u00ED voln\u00FDch lehk\u00FDch \u0159et\u011Bzc\u016F (FLC) v s\u00E9ru jako nov\u00E9ho markeru k posouzen\u00ED aktivity monoklon\u00E1ln\u00EDch gamapati\u00ED. C\u00EDle byly formulov\u00E1ny na z\u00E1klad\u011B potenci\u00E1ln\u011B nejvhodn\u011Bj\u0161\u00EDch indikac\u00ED pro jeho pou\u017Eit\u00ED v klinick\u00E9 praxi. Spolupracovali jsme s registrem monoklon\u00E1ln\u00EDch gamapati\u00ED a analyzovali celkem 1439 pacient\u016F s monoklon\u00E1ln\u00EDmi gamapatiemi. Potvrdili jsme platnost stratifika\u010Dn\u00EDho modelu MGUS Mayo Clinic. Sou\u010Dasn\u011B s t\u00EDm jsme identifikovali dal\u0161\u00ED potenci\u00E1ln\u011B vhodn\u00E9 znaky, kter\u00E9 pl\u00E1nujeme ov\u011B\u0159it v r\u00E1mci dal\u0161\u00EDch anal\u00FDz a p\u0159\u00EDpadn\u011B je vyu\u017E\u00EDt p\u0159i p\u0159\u00EDprav\u011B podrobn\u011Bj\u0161\u00EDho stratifika\u010Dn\u00EDho modelu. Normalizace pom\u011Bru FLC v kompletn\u00ED remisi nebyla spjata se signifikantn\u011B del\u0161\u00ED dobou do progrese, a\u010Dkoli byl pozorov\u00E1n trend k jej\u00EDmu zlep\u0161en\u00ED."@cs . "I, P(NS10387), P(NS10406), P(NT12215)" . "H\u00E1jek, R." . . . "RIV/00179906:_____/12:10127439!RIV13-MZ0-00179906" . "Klincov\u00E1, M." . "N\u00E1\u0161 projekt byl zam\u011B\u0159en na anal\u00FDzu mo\u017En\u00E9ho vyu\u017Eit\u00ED stanoven\u00ED voln\u00FDch lehk\u00FDch \u0159et\u011Bzc\u016F (FLC) v s\u00E9ru jako nov\u00E9ho markeru k posouzen\u00ED aktivity monoklon\u00E1ln\u00EDch gamapati\u00ED. C\u00EDle byly formulov\u00E1ny na z\u00E1klad\u011B potenci\u00E1ln\u011B nejvhodn\u011Bj\u0161\u00EDch indikac\u00ED pro jeho pou\u017Eit\u00ED v klinick\u00E9 praxi. Spolupracovali jsme s registrem monoklon\u00E1ln\u00EDch gamapati\u00ED a analyzovali celkem 1439 pacient\u016F s monoklon\u00E1ln\u00EDmi gamapatiemi. Potvrdili jsme platnost stratifika\u010Dn\u00EDho modelu MGUS Mayo Clinic. Sou\u010Dasn\u011B s t\u00EDm jsme identifikovali dal\u0161\u00ED potenci\u00E1ln\u011B vhodn\u00E9 znaky, kter\u00E9 pl\u00E1nujeme ov\u011B\u0159it v r\u00E1mci dal\u0161\u00EDch anal\u00FDz a p\u0159\u00EDpadn\u011B je vyu\u017E\u00EDt p\u0159i p\u0159\u00EDprav\u011B podrobn\u011Bj\u0161\u00EDho stratifika\u010Dn\u00EDho modelu. Normalizace pom\u011Bru FLC v kompletn\u00ED remisi nebyla spjata se signifikantn\u011B del\u0161\u00ED dobou do progrese, a\u010Dkoli byl pozorov\u00E1n trend k jej\u00EDmu zlep\u0161en\u00ED." . . "Importance of FLC determination in patients with MGUS and in complete remission of multiple myeloma"@en . "Our project was focused on verifying the usefulness of free light chain (FLC) analysis as the new marker for evaluation of the activity of monoclonal gammopathies. Formulated goals of this project represented the most likely beneficial indications for FLC use in clinical practice. We collaborated with Registry of Monoclonal Gammopathies database of Czech Republic and analyzed 1439 patients with monoclonal gammopathies. We were able to confirm validity of the prognostic model of MGUS stratification originally developed by Mayo Clinic. Moreover several other independent prognostic factors not included in the mentioned model have been identified, which we plan to include in the further analysis and development of more detailed prognostic model. Normalization of FLC ratio was not connected to statistically significant prolongation of complete remission duration, however trend towards it was observed."@en . . . "V\u00FDznam stanoven\u00ED FLC u nemocn\u00FDch MGUS a v kompletn\u00ED remisi u mnoho\u010Detn\u00E9ho myelomu"@cs . "4"^^ . . "Gregora, E." . "6"^^ . "RIV/00179906:_____/12:10127439" . "Importance of FLC determination in patients with MGUS and in complete remission of multiple myeloma"@en . "RMG registry; risk factors; free light chains; monoclonal gammopathy of undetermined significance"@en . . "1210-7921" . "V\u00E1vrov\u00E1, Jaroslava" . . "V\u00FDznam stanoven\u00ED FLC u nemocn\u00FDch MGUS a v kompletn\u00ED remisi u mnoho\u010Detn\u00E9ho myelomu" . "Mal\u00FD, Jaroslav" . "180232" . . . "12"^^ . "2" . . . "Radocha, Jakub" . . "Mach\u00E1lkov\u00E1, Kate\u0159ina" . "\u0160\u010Dudla, V." . . . . "Maisnar, Vladim\u00EDr" . "20" . . . "Sandeck\u00E1, V." .