"Mencl, Karel" . "A significant increase in the frequency of systemic fungal infections in patients with serious diseases was observed in the last twenty years. Thus a number of new antifungal agents were developed, but micromycets' resistance was also gradually growing in the population. Based on the need for an early and objective detection of this resistance the importance of determination of susceptibility to antifungal agents in vitro, including the need for unificatin of methodologies, was increasing.In this article the development and basic features of current standardized procedures are summarized and the significance of derived commercial products for diagnostic practice is assessed. In further parts of the article current approaches to the interpretation of results are discussed and the importance of clinical breakpoints is commented. The circumstances under which it is advisable to perform suscceptibility testint are mentioned and knowledge, limiting our options in terms of properties of individual groups of antifungals and micromycets species, is listed. In conclusion, recommendations for the use of methods for detecting resistance of yeasts an filamentous fungi in isolates obtained from immunocompromised patients, through summarizatin of the most important concepts, are developed."@en . . . . "p\u0159\u00EDl. \u010D. 5" . "13" . . "V posledn\u00EDch dvaceti letech do\u0161lo k v\u00FDrazn\u00E9mu n\u00E1r\u016Fstu frekvence syst\u00E9mov\u00FDch myk\u00F3z u pacient\u016F se z\u00E1va\u017En\u00FDmi onemocn\u011Bn\u00EDmi.Proto byla vyvinuta \u0159ada nov\u00FDch antimykotik, postupn\u011B v\u0161ak tak\u00E9 nar\u016Fstala rezistence v populaci mikromycet. Na z\u00E1klad\u011B nutnosti jej\u00ED v\u010Dasn\u00E9 a objektivn\u00ED detekce stoupal i v\u00FDznam stanoven\u00ED citlivosti k antifung\u00E1ln\u00EDm l\u00E1tk\u00E1m in vitro v\u010Detn\u011B pot\u0159eby sjednocen\u00ED metodik. V \u010Dl\u00E1nku je shrnut v\u00FDvoj a z\u00E1kladn\u00ED rysy sou\u010Dasn\u00FDch standardizovan\u00FDch postup\u016F a zhodnocen v\u00FDznam odvozen\u00FDch komer\u010Dn\u00EDch produkt\u016F pro diagnostickou praxi. V dal\u0161\u00EDch \u010D\u00E1stech jsou diskutov\u00E1ny sou\u010Dasn\u00E9 p\u0159\u00EDstupy k interpretaci v\u00FDsledk\u016F a komentov\u00E1n v\u00FDznam klinick\u00FDch breakpoint\u016F Jsou zmi\u0148ov\u00E1ny okolnosti, za kter\u00FDch je vhodn\u00E9 prov\u00E1d\u011Bt testov\u00E1n\u00ED citlivosti. V z\u00E1v\u011Bru jsou shrnut\u00EDm nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch poznatk\u016F vytvo\u0159ena doporu\u010Den\u00ED pro vyu\u017Eit\u00ED metod k pr\u016Fkazu rezistence kvasinek i vl\u00E1knit\u00FDch hub u izol\u00E1t\u016F z\u00EDskan\u00FDch od imunosuprimovan\u00FDch pacient\u016F." . . . "Buchta, Vladim\u00EDr" . "1"^^ . "15"^^ . . "Testov\u00E1n\u00ED citlivosti mikromycet k antimykotik\u016Fm in vitro u imunosuprimovan\u00FDch pacient\u016F - doporu\u010Den\u00ED odborn\u00EDk\u016F s podporou CELL a SLM \u010CSL JEP"@cs . . "Testov\u00E1n\u00ED citlivosti mikromycet k antimykotik\u016Fm in vitro u imunosuprimovan\u00FDch pacient\u016F - doporu\u010Den\u00ED odborn\u00EDk\u016F s podporou CELL a SLM \u010CSL JEP"@cs . "I" . . "Testov\u00E1n\u00ED citlivosti mikromycet k antimykotik\u016Fm in vitro u imunosuprimovan\u00FDch pacient\u016F - doporu\u010Den\u00ED odborn\u00EDk\u016F s podporou CELL a SLM \u010CSL JEP" . . . "Mall\u00E1tov\u00E1, Na\u010Fa" . "recommendations; expert; patients; immunosuppressed; in vitro; antifungals; susceptibility; micromycetes; Testing"@en . "5"^^ . "[79DA1E420EC3]" . . "Testov\u00E1n\u00ED citlivosti mikromycet k antimykotik\u016Fm in vitro u imunosuprimovan\u00FDch pacient\u016F - doporu\u010Den\u00ED odborn\u00EDk\u016F s podporou CELL a SLM \u010CSL JEP" . "RIV/00179906:_____/11:10109416!RIV12-MZ0-00179906" . . . "Testing of micromycets' susceptibility to antifungals in vitro in immunosuppressed patients - expert recommendations with the support of CELL and SLM CLS JEP"@en . . . . "Kocmalov\u00E1, Iva" . "1212-4184" . "Hamal, Petr" . "RIV/00179906:_____/11:10109416" . . . "Testing of micromycets' susceptibility to antifungals in vitro in immunosuppressed patients - expert recommendations with the support of CELL and SLM CLS JEP"@en . . "CZ - \u010Cesk\u00E1 republika" . "V posledn\u00EDch dvaceti letech do\u0161lo k v\u00FDrazn\u00E9mu n\u00E1r\u016Fstu frekvence syst\u00E9mov\u00FDch myk\u00F3z u pacient\u016F se z\u00E1va\u017En\u00FDmi onemocn\u011Bn\u00EDmi.Proto byla vyvinuta \u0159ada nov\u00FDch antimykotik, postupn\u011B v\u0161ak tak\u00E9 nar\u016Fstala rezistence v populaci mikromycet. Na z\u00E1klad\u011B nutnosti jej\u00ED v\u010Dasn\u00E9 a objektivn\u00ED detekce stoupal i v\u00FDznam stanoven\u00ED citlivosti k antifung\u00E1ln\u00EDm l\u00E1tk\u00E1m in vitro v\u010Detn\u011B pot\u0159eby sjednocen\u00ED metodik. V \u010Dl\u00E1nku je shrnut v\u00FDvoj a z\u00E1kladn\u00ED rysy sou\u010Dasn\u00FDch standardizovan\u00FDch postup\u016F a zhodnocen v\u00FDznam odvozen\u00FDch komer\u010Dn\u00EDch produkt\u016F pro diagnostickou praxi. V dal\u0161\u00EDch \u010D\u00E1stech jsou diskutov\u00E1ny sou\u010Dasn\u00E9 p\u0159\u00EDstupy k interpretaci v\u00FDsledk\u016F a komentov\u00E1n v\u00FDznam klinick\u00FDch breakpoint\u016F Jsou zmi\u0148ov\u00E1ny okolnosti, za kter\u00FDch je vhodn\u00E9 prov\u00E1d\u011Bt testov\u00E1n\u00ED citlivosti. V z\u00E1v\u011Bru jsou shrnut\u00EDm nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch poznatk\u016F vytvo\u0159ena doporu\u010Den\u00ED pro vyu\u017Eit\u00ED metod k pr\u016Fkazu rezistence kvasinek i vl\u00E1knit\u00FDch hub u izol\u00E1t\u016F z\u00EDskan\u00FDch od imunosuprimovan\u00FDch pacient\u016F."@cs . "Postgradu\u00E1ln\u00ED medic\u00EDna" . . "234968" .