. . "Zad\u00E1k, Zden\u011Bk" . "Tich\u00E1, Alena" . "0042-773X" . "Pokroky v metabolizmu a v\u00FD\u017Eiv\u011B 2011 a cesta k personalizovan\u00E9 l\u00E9\u010Db\u011B" . . . "57" . "Pokroky v metabolizmu a v\u00FD\u017Eiv\u011B 2011 a cesta k personalizovan\u00E9 l\u00E9\u010Db\u011B"@cs . "RIV/00179906:_____/11:10107464" . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . . "Advances in metabolism and nutrition 2011 and the route to personalized treatment"@en . "Hronek, Miloslav" . "221037" . . "Hy\u0161pler, Radom\u00EDr" . "RIV/00179906:_____/11:10107464!RIV12-MZ0-00179906" . . "Z(MZ0FNHK2005)" . . "Pokroky v metabolizmu a v\u00FD\u017Eiv\u011B 2011 a cesta k personalizovan\u00E9 l\u00E9\u010Db\u011B" . "Advances in metabolism and nutrition 2011 and the route to personalized treatment"@en . . . "Current model of metabolic and nutritional disorders management utilizes modern techniques that promote some of the nutritional techniques to pharmacotherapy. This approach is demonstrated on an example of multiple organ failure and systemic inflammatory reaction managed with pharmacologically active nutritional substrates, such as arginine, glutamine, taurine, threonine and cysteine. Treatment of sarcopenia in older age is also discussed. Personalized nourishment as a component part of a wider term personalized medicine represents a new approach that requires recognition of individual differences in human genome and its expression. However, this approach also requires a change of attitude towards laboratory diagnostics and clinical practice, with patients and clinical prediction as the focal point. From this perspective, there is a need to replace current traditional laboratory tests with a new system that utilizes molecular biology and bioinformatics."@en . "11" . . "Nov\u00E1 koncepce terapie poruch metabolizmu a v\u00FD\u017Eivy je zalo\u017Eena na modern\u00EDch p\u0159\u00EDstupech, kter\u00E9 stav\u00ED n\u011Bkter\u00E9 nutri\u010Dn\u00ED postupy na \u00FArove\u0148 farmakoterapie. Tento p\u0159\u00EDstup je demonstrov\u00E1n na p\u0159\u00EDkladu l\u00E9\u010Dby multiorg\u00E1nov\u00E9ho selh\u00E1n\u00ED a syst\u00E9mov\u00E9 inflamatorn\u00ED reakce, kdy jsou vyu\u017E\u00EDv\u00E1ny nutri\u010Dn\u00ED substr\u00E1ty s farmakologick\u00FDm \u00FA\u010Dinkem jako arginin, glutamin, taurin, threonin a cystein. Dal\u0161\u00ED diskutovanou problematikou je l\u00E9\u010Dba sarkopenie ve st\u00E1\u0159\u00ED. Personalizovan\u00E1 v\u00FD\u017Eiva jako sou\u010D\u00E1st \u0161ir\u0161\u00EDho pojet\u00ED personalizovan\u00E9 medic\u00EDny p\u0159edstavuje novou cestu, kter\u00E1 je zalo\u017Eena na pozn\u00E1n\u00ED individu\u00E1ln\u00EDch rozd\u00EDl\u016F v lidsk\u00E9m genomu a jeho expresi. Tato cesta v\u0161ak vy\u017Eaduje zcela odli\u0161n\u00FD p\u0159\u00EDstup k laboratorn\u00ED diagnostice i klinick\u00E9mu pojet\u00ED, kter\u00E9 je mnohem v\u00EDce orientov\u00E1no na jednotliv\u00E9ho pacienta a klinickou predikci. Z tohoto hlediska se jev\u00ED nutnost\u00ED nahradit dosavadn\u00ED klasick\u00E9 laboratorn\u00ED testy nov\u00FDm syst\u00E9mem, kter\u00FD vyu\u017E\u00EDv\u00E1 molekul\u00E1rn\u00ED biologii a bioinformatiku." . . . . "[65EAA8F07568]" . . "4"^^ . "CZ - \u010Cesk\u00E1 republika" . . "4"^^ . "5"^^ . . . . "sarcopenia; multiple organ failure; nutrigenomics; nutritional pharmacology; personalized medicine"@en . "Pokroky v metabolizmu a v\u00FD\u017Eiv\u011B 2011 a cesta k personalizovan\u00E9 l\u00E9\u010Db\u011B"@cs . "Nov\u00E1 koncepce terapie poruch metabolizmu a v\u00FD\u017Eivy je zalo\u017Eena na modern\u00EDch p\u0159\u00EDstupech, kter\u00E9 stav\u00ED n\u011Bkter\u00E9 nutri\u010Dn\u00ED postupy na \u00FArove\u0148 farmakoterapie. Tento p\u0159\u00EDstup je demonstrov\u00E1n na p\u0159\u00EDkladu l\u00E9\u010Dby multiorg\u00E1nov\u00E9ho selh\u00E1n\u00ED a syst\u00E9mov\u00E9 inflamatorn\u00ED reakce, kdy jsou vyu\u017E\u00EDv\u00E1ny nutri\u010Dn\u00ED substr\u00E1ty s farmakologick\u00FDm \u00FA\u010Dinkem jako arginin, glutamin, taurin, threonin a cystein. Dal\u0161\u00ED diskutovanou problematikou je l\u00E9\u010Dba sarkopenie ve st\u00E1\u0159\u00ED. Personalizovan\u00E1 v\u00FD\u017Eiva jako sou\u010D\u00E1st \u0161ir\u0161\u00EDho pojet\u00ED personalizovan\u00E9 medic\u00EDny p\u0159edstavuje novou cestu, kter\u00E1 je zalo\u017Eena na pozn\u00E1n\u00ED individu\u00E1ln\u00EDch rozd\u00EDl\u016F v lidsk\u00E9m genomu a jeho expresi. Tato cesta v\u0161ak vy\u017Eaduje zcela odli\u0161n\u00FD p\u0159\u00EDstup k laboratorn\u00ED diagnostice i klinick\u00E9mu pojet\u00ED, kter\u00E9 je mnohem v\u00EDce orientov\u00E1no na jednotliv\u00E9ho pacienta a klinickou predikci. Z tohoto hlediska se jev\u00ED nutnost\u00ED nahradit dosavadn\u00ED klasick\u00E9 laboratorn\u00ED testy nov\u00FDm syst\u00E9mem, kter\u00FD vyu\u017E\u00EDv\u00E1 molekul\u00E1rn\u00ED biologii a bioinformatiku."@cs . . .