"Postaven\u00ED hepcidinu v diagnostice a l\u00E9\u010Db\u011B an\u00E9mi\u00ED"@cs . "221854" . . "Hepcidin is small peptide hormone consisting of 25 amino acids that is predominantly synthetized in the liver. Hepcidin plays a key role in the regulation of iron homeostasis. Hepcidin acts by regulation of its receptor, ferroportin. Ferroportin presents the sole cellular iron exporter and the iron-hepcidin axis contribution to the pathogenesis of different anemias and on the other hand iron overload. Hepcidin synthesis is induced by iron overload, inflammation and suppressed by erythropoieses of hypoxia. It is also possible that in the future, our therapeutic experience will be enhanced hepcidin-agonists or hepcidin-antagonists."@en . "1"^^ . "1214-8687" . . . "RIV/00179906:_____/11:10105446" . . "RIV/00179906:_____/11:10105446!RIV12-MZ0-00179906" . "Postaven\u00ED hepcidinu v diagnostice a l\u00E9\u010Db\u011B an\u00E9mi\u00ED"@cs . "The role of hepcidin in the diagnosis and treatment of anemias"@en . . . "3" . "Postaven\u00ED hepcidinu v diagnostice a l\u00E9\u010Db\u011B an\u00E9mi\u00ED" . "3"^^ . "anemia; iron metabolism; ferroportin; hepcidin"@en . "Medic\u00EDna pro praxi" . . "Postaven\u00ED hepcidinu v diagnostice a l\u00E9\u010Db\u011B an\u00E9mi\u00ED" . . "B\u011Blohl\u00E1vkov\u00E1, Petra" . . . "[0A8DFA034119]" . . "Hepcidin je mal\u00FD peptidov\u00FD hormon tvo\u0159en\u00FD 25 aminokyselinami, kter\u00FD je syntetizov\u00E1n p\u0159edev\u0161\u00EDm v j\u00E1trech. Hepcidin hraje v organismu kl\u00ED\u010Dovou roli v regulaci homeost\u00E1zy \u017Eeleza. \u00DA\u010Dinek hepcidinu je zprost\u0159edkov\u00E1n regulac\u00ED degradace jeho receptoru feroportinu. Feroportin p\u0159edstavuje jedin\u00FD bun\u011B\u010Dn\u00FD export\u00E9r \u017Eeleza a naru\u0161en\u00ED osy hepcidin-feroportin m\u00E1 pod\u00EDl na patogenezi vzniku \u0159ady an\u00E9mi\u00ED a na druh\u00E9 stran\u011B na rozvoji p\u0159et\u00ED\u017Een\u00ED \u017Eelezem. Synt\u00E9za hepcidinu je indukov\u00E1na nadbytkem \u017Eeleza, z\u00E1n\u011Btem a inhibov\u00E1na erytropo\u00E9zou a hypoxi\u00ED. Stanoven\u00ED hladiny hepcidinu by mohlo p\u0159isp\u011Bt v diagnostice r\u016Fzn\u00FDch forem an\u00E9mi\u00ED. Nen\u00ED vylou\u010Deno, \u017Ee v budoucnosti budou l\u00E9\u010Debn\u00E9 mo\u017Enosti roz\u0161\u00ED\u0159eny o l\u00E9\u010Dbu agonisty nebo antagonisty hepcidinu."@cs . . "The role of hepcidin in the diagnosis and treatment of anemias"@en . "Hepcidin je mal\u00FD peptidov\u00FD hormon tvo\u0159en\u00FD 25 aminokyselinami, kter\u00FD je syntetizov\u00E1n p\u0159edev\u0161\u00EDm v j\u00E1trech. Hepcidin hraje v organismu kl\u00ED\u010Dovou roli v regulaci homeost\u00E1zy \u017Eeleza. \u00DA\u010Dinek hepcidinu je zprost\u0159edkov\u00E1n regulac\u00ED degradace jeho receptoru feroportinu. Feroportin p\u0159edstavuje jedin\u00FD bun\u011B\u010Dn\u00FD export\u00E9r \u017Eeleza a naru\u0161en\u00ED osy hepcidin-feroportin m\u00E1 pod\u00EDl na patogenezi vzniku \u0159ady an\u00E9mi\u00ED a na druh\u00E9 stran\u011B na rozvoji p\u0159et\u00ED\u017Een\u00ED \u017Eelezem. Synt\u00E9za hepcidinu je indukov\u00E1na nadbytkem \u017Eeleza, z\u00E1n\u011Btem a inhibov\u00E1na erytropo\u00E9zou a hypoxi\u00ED. Stanoven\u00ED hladiny hepcidinu by mohlo p\u0159isp\u011Bt v diagnostice r\u016Fzn\u00FDch forem an\u00E9mi\u00ED. Nen\u00ED vylou\u010Deno, \u017Ee v budoucnosti budou l\u00E9\u010Debn\u00E9 mo\u017Enosti roz\u0161\u00ED\u0159eny o l\u00E9\u010Dbu agonisty nebo antagonisty hepcidinu." . . "8" . . "V" . "1"^^ . "CZ - \u010Cesk\u00E1 republika" . . .