"Chronick\u00E1 lymfocyt\u00E1rn\u00ED leukemie (CLL) je nej\u010Dast\u011Bj\u0161\u00EDm typem leukemie v z\u00E1padn\u00ED populaci. I p\u0159es svoji vysokou incidenci z\u016Fst\u00E1vala CLL po velmi dlouhou dobu onemocn\u011Bn\u00EDm, kter\u00E9 na rozd\u00EDl od jin\u00FDch lymfoproliferac\u00ED p\u0159\u00EDli\u0161 nepoutalo pozornost. V n\u011Bkolika posledn\u00EDch letech se v\u0161ak pohled na tuto chorobu podstatn\u011B zm\u011Bnil a d\u00EDky intenzivn\u00EDmu studiu byly z\u00EDsk\u00E1ny nov\u00E9 poznatky v oblasti patogeneze, prognostick\u00FDch faktor\u016F a v neposledn\u00ED \u0159ad\u011B tak\u00E9 v oblasti l\u00E9\u010Dby se zaveden\u00EDm \u00FA\u010Dinn\u00FDch intenzivn\u00EDch l\u00E9\u010Debn\u00FDch postup\u016F. Dnes ji\u017E v\u00EDme, \u017Ee pou\u017Eit\u00ED klasick\u00FDch prognostick\u00FDch faktor\u016F je ke stanoven\u00ED individu\u00E1ln\u00ED progn\u00F3zy nemocn\u00FDch s CLL nedostate\u010Dn\u00E9. Uplatn\u011Bn\u00EDm modern\u00EDch prognostick\u00FDch ukazatel\u016F je v\u0161ak ji\u017E v dob\u011B stanoven\u00ED diagn\u00F3zy mo\u017En\u00E9 rozd\u011Blit nemocn\u00E9, zejm\u00E9na v \u010Dasn\u00FDch klinick\u00FDch stadi\u00EDch, do skupin v\u00FDznamn\u011B se li\u0161\u00EDc\u00EDch progn\u00F3zou, a p\u0159edpov\u011Bd\u011Bt tak klinick\u00FD pr\u016Fb\u011Bh onemocn\u011Bn\u00ED."@cs . . . . . "Chronick\u00E1 lymfocyt\u00E1rn\u00ED leukemie (CLL) je nej\u010Dast\u011Bj\u0161\u00EDm typem leukemie v z\u00E1padn\u00ED populaci. I p\u0159es svoji vysokou incidenci z\u016Fst\u00E1vala CLL po velmi dlouhou dobu onemocn\u011Bn\u00EDm, kter\u00E9 na rozd\u00EDl od jin\u00FDch lymfoproliferac\u00ED p\u0159\u00EDli\u0161 nepoutalo pozornost. V n\u011Bkolika posledn\u00EDch letech se v\u0161ak pohled na tuto chorobu podstatn\u011B zm\u011Bnil a d\u00EDky intenzivn\u00EDmu studiu byly z\u00EDsk\u00E1ny nov\u00E9 poznatky v oblasti patogeneze, prognostick\u00FDch faktor\u016F a v neposledn\u00ED \u0159ad\u011B tak\u00E9 v oblasti l\u00E9\u010Dby se zaveden\u00EDm \u00FA\u010Dinn\u00FDch intenzivn\u00EDch l\u00E9\u010Debn\u00FDch postup\u016F. Dnes ji\u017E v\u00EDme, \u017Ee pou\u017Eit\u00ED klasick\u00FDch prognostick\u00FDch faktor\u016F je ke stanoven\u00ED individu\u00E1ln\u00ED progn\u00F3zy nemocn\u00FDch s CLL nedostate\u010Dn\u00E9. Uplatn\u011Bn\u00EDm modern\u00EDch prognostick\u00FDch ukazatel\u016F je v\u0161ak ji\u017E v dob\u011B stanoven\u00ED diagn\u00F3zy mo\u017En\u00E9 rozd\u011Blit nemocn\u00E9, zejm\u00E9na v \u010Dasn\u00FDch klinick\u00FDch stadi\u00EDch, do skupin v\u00FDznamn\u011B se li\u0161\u00EDc\u00EDch progn\u00F3zou, a p\u0159edpov\u011Bd\u011Bt tak klinick\u00FD pr\u016Fb\u011Bh onemocn\u011Bn\u00ED." . "10" . . "RIV/00179906:_____/11:10104903" . "Chronic lymphocytic leukemia (CLL) is the most common leukemia type in Western countries. Even incidence of CLL is high, this disease remained beyond interest for a very long time. However, in the last few years of this disease fundamentally changed and due to intensive study, new knowledge especially on pathogenesis, prognostic factors and therapy based on intensive therapeutic procedures were made. Today we know that usage of classical prognostic factors is insufficient for prognosis evaluation in the individuals. However modern and new markers have potential to distinguish patients in early stages to groups with significantly different prognosis and predict clinical course of the disease."@en . . "Prognostic markers in chronic lymphocytic leukemia"@en . "Smolej, Luk\u00E1\u0161" . . . "[5F06F1CFD8BF]" . . . "11"^^ . "57" . . "7"^^ . . "\u017D\u00E1k, Pavel" . "CZ - \u010Cesk\u00E1 republika" . . . "Belada, David" . . . "7"^^ . "Moty\u010Dkov\u00E1, Monika" . "Prognostick\u00E9 faktory u chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie"@cs . . "cytogenetic aberrations; IgVH mutation status; prognosis; prognostic factors; chronic lymphocytic leukemia"@en . "0042-773X" . "Prognostic markers in chronic lymphocytic leukemia"@en . "Prognostick\u00E9 faktory u chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie"@cs . . . "Prognostick\u00E9 faktory u chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie" . "Mal\u00FD, Jaroslav" . . "Prognostick\u00E9 faktory u chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie" . . "Andr\u00FDs, Ctirad" . . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "Vroblov\u00E1, Vladim\u00EDra" . . "224383" . "I, Z(MZ0FNHK2005)" . "RIV/00179906:_____/11:10104903!RIV12-MZ0-00179906" . .